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Q92I98 (TLCB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 2
Alternative name(s):
ADP/ATP translocase 2
Gene names
Name:tlcB
Synonyms:tlc2
Ordered Locus Names:RC0522
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP:ADP antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507ADP,ATP carrier protein 2
PRO_0000286470

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane67 – 8721Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane292 – 31221Helical; Potential
Transmembrane333 – 35321Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane393 – 41321Helical; Potential
Transmembrane451 – 47121Helical; Potential
Transmembrane474 – 49421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q92I98 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 49A92CD91E300C70

FASTA50758,365
        10         20         30         40         50         60 
MDSVDSNFTI WNKARNSKFR HIVWPIRSYE LTKFIPMALL MFFILLNQNL VRSIKDSFVV 

        70         80         90        100        110        120 
TLISSEVLSF IKLWGEMPMG ILFVIFYSKL CNIMTTEQVF RIITGTFLFF FAIFGFILFP 

       130        140        150        160        170        180 
YREFFHPDPE LIKHYITVLP HLKWFLIIWG QWSLVLFYIM GELWPVIVFT LLYWQLANKI 

       190        200        210        220        230        240 
TKVEEAPRFY SFFTLFGQTN LLISGTVIIY FAKSEHFLLP LFSHLNDTNE ILLKSFITVI 

       250        260        270        280        290        300 
LISGLICLAL HKLIDKSVVE ADKNIKFKNQ RMDILKLSLV DSAKVILTSR YLGFICLLVM 

       310        320        330        340        350        360 
SYSMSISLIE GLWMSKVKQL YPATKDFIAY HGKVFFWTGI LTLVSAFLGS SLIRICGWFW 

       370        380        390        400        410        420 
GAIITPIMMF GAGVMFFSFT VFENHLGNIV NTLGYSAPLV VIVFIGGLWH VLSKSVKYSL 

       430        440        450        460        470        480 
FDATKEMVYI PLDSEMKTKG KAAVDVMGAK IGKSIGAIIQ FISFSIFPNA IHNDIAGLLM 

       490        500 
FSFIIVCLLW LYGVKVLSKY YNKMIQR 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03060.1.
PIRB97765.
RefSeqNP_360159.1. NC_003103.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0522.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03060; AAL03060; RC0522.
GeneID927640.
KEGGrco:RC0522.
PATRIC17888288. VBIRicCon45613_0597.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3202.
HOGENOMHOG000238123.
OMAHIVWPIR.
OrthoDBEOG6BCSND.
ProtClustDBCLSK870724.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
[Graphical view]
PfamPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCB_RICCN
AccessionPrimary (citable) accession number: Q92I98
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names