Q92I98 (TLCB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP,ATP carrier protein 2

Alternative name(s):
ADP/ATP translocase 2

Gene names

Name:	tlcB
Synonyms:	tlc2
Ordered Locus Names:	RC0522

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	ADP,ATP carrier protein 2		PRO_0000286470
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	192 – 212	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Transmembrane	292 – 312	21	Helical; Potential
	Transmembrane	333 – 353	21	Helical; Potential
	Transmembrane	357 – 377	21	Helical; Potential
	Transmembrane	393 – 413	21	Helical; Potential
	Transmembrane	451 – 471	21	Helical; Potential
	Transmembrane	474 – 494	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92I98 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 49A92CD91E300C70	FASTA	507	58,365
	10 20 30 40 50 60 MDSVDSNFTI WNKARNSKFR HIVWPIRSYE LTKFIPMALL MFFILLNQNL VRSIKDSFVV 70 80 90 100 110 120 TLISSEVLSF IKLWGEMPMG ILFVIFYSKL CNIMTTEQVF RIITGTFLFF FAIFGFILFP 130 140 150 160 170 180 YREFFHPDPE LIKHYITVLP HLKWFLIIWG QWSLVLFYIM GELWPVIVFT LLYWQLANKI 190 200 210 220 230 240 TKVEEAPRFY SFFTLFGQTN LLISGTVIIY FAKSEHFLLP LFSHLNDTNE ILLKSFITVI 250 260 270 280 290 300 LISGLICLAL HKLIDKSVVE ADKNIKFKNQ RMDILKLSLV DSAKVILTSR YLGFICLLVM 310 320 330 340 350 360 SYSMSISLIE GLWMSKVKQL YPATKDFIAY HGKVFFWTGI LTLVSAFLGS SLIRICGWFW 370 380 390 400 410 420 GAIITPIMMF GAGVMFFSFT VFENHLGNIV NTLGYSAPLV VIVFIGGLWH VLSKSVKYSL 430 440 450 460 470 480 FDATKEMVYI PLDSEMKTKG KAAVDVMGAK IGKSIGAIIQ FISFSIFPNA IHNDIAGLLM 490 500 FSFIIVCLLW LYGVKVLSKY YNKMIQR

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03060.1.
PIR	B97765.
RefSeq	NP_360159.1. NC_003103.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0522.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03060; AAL03060; RC0522.
GeneID	927640.
KEGG	rco:RC0522.
PATRIC	17888288. VBIRicCon45613_0597.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3202.
HOGENOM	HOG000238123.
OMA	HIVWPIR.
ProtClustDB	CLSK870724.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00769. AAA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TLCB_RICCN

Accession

Primary (citable) accession number: Q92I98

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program