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Q92I97

- PYRG_RICCN

UniProt

Q92I97 - PYRG_RICCN

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Protein

CTP synthase

Gene

pyrG

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei379 – 3791NucleophileUniRule annotation
Active sitei509 – 5091UniRule annotation
Active sitei511 – 5111UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. CTP synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Protein family/group databases

MEROPSiC26.964.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
Alternative name(s):
CTP synthetaseUniRule annotation
UTP--ammonia ligaseUniRule annotation
Gene namesi
Name:pyrGUniRule annotation
Ordered Locus Names:RC0523
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537CTP synthasePRO_0000138216Add
BLAST

Proteomic databases

PRIDEiQ92I97.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0523.

Structurei

3D structure databases

ProteinModelPortaliQ92I97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 536247Glutamine amidotransferase type-1UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 252252Aminator domainAdd
BLAST

Sequence similaritiesi

Belongs to the CTP synthase family.UniRule annotation
Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0504.
HOGENOMiHOG000077515.
KOiK01937.
OMAiSVNIKYI.
OrthoDBiEOG6RC3NR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92I97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHFIFVTGG VVSSLGKGLT AASLAMLLQA KGFRVSVRKL DPYLNIDPGT
60 70 80 90 100
MNPHEHGEVY VTDDGAETDL DLGHYERFTG VSACKFDSIT TGAIYSKLLK
110 120 130 140 150
DERLGNYAGV TVQVIPHVTN IIKDFILSNT KGFDFIICEI GGTVGDIEGL
160 170 180 190 200
PFFEAIRQIG NKLKSENCLF IHLTLLPYVK TARELKIKPT QHSVKALRAI
210 220 230 240 250
GISPNILVCR AERNISKGEI DKISLLCNIE SEYVVPAIDQ KNIYLVPIAY
260 270 280 290 300
HNSGLDNKVL KFFNINIMPS KLDKWHDIIN RLKDSNSKVR IAIIAKYHKL
310 320 330 340 350
KDAYKSVIEA LDHAGIYYKY KIDLVWINAE NLTEENINKK LLDIDGILVP
360 370 380 390 400
GGFGERATKG TIIAIKYART NNIPFFGICF GMQLATIEIA QNLIGIKDAV
410 420 430 440 450
TEEFKVDGTK IIEKINKNCE DSKITIENVK KTMRLGSYPC SLVASTIAAN
460 470 480 490 500
AYKSLEINER HRHRYKFNNE FQNIFEKHGI VFSGFSKDEE IVEIIELPLL
510 520 530
RWFVGVQFHP EFKSKPFEAH PLFIQFIKAA IEYNKCN
Length:537
Mass (Da):60,451
Last modified:December 1, 2001 - v1
Checksum:i42DD5159B7A20680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03061.1.
PIRiC97765.
RefSeqiNP_360160.1. NC_003103.1.
WP_010977162.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03061; AAL03061; RC0523.
GeneIDi928731.
KEGGirco:RC0523.
PATRICi17888290. VBIRicCon45613_0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03061.1 .
PIRi C97765.
RefSeqi NP_360160.1. NC_003103.1.
WP_010977162.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92I97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0523.

Protein family/group databases

MEROPSi C26.964.

Proteomic databases

PRIDEi Q92I97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03061 ; AAL03061 ; RC0523 .
GeneIDi 928731.
KEGGi rco:RC0523.
PATRICi 17888290. VBIRicCon45613_0598.

Phylogenomic databases

eggNOGi COG0504.
HOGENOMi HOG000077515.
KOi K01937.
OMAi SVNIKYI.
OrthoDBi EOG6RC3NR.

Enzyme and pathway databases

UniPathwayi UPA00159 ; UER00277 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_01227. PyrG.
InterProi IPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11550. PTHR11550. 1 hit.
Pfami PF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00337. PyrG. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiPYRG_RICCN
AccessioniPrimary (citable) accession number: Q92I97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3