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Q92I97

- PYRG_RICCN

UniProt

Q92I97 - PYRG_RICCN

Protein

CTP synthase

Gene

pyrG

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

    Catalytic activityi

    ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei379 – 3791NucleophileUniRule annotation
    Active sitei509 – 5091UniRule annotation
    Active sitei511 – 5111UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. CTP synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00159; UER00277.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
    Alternative name(s):
    CTP synthetaseUniRule annotation
    UTP--ammonia ligaseUniRule annotation
    Gene namesi
    Name:pyrGUniRule annotation
    Ordered Locus Names:RC0523
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537CTP synthasePRO_0000138216Add
    BLAST

    Proteomic databases

    PRIDEiQ92I97.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0523.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92I97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 536247Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 252252Aminator domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CTP synthase family.UniRule annotation
    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0504.
    HOGENOMiHOG000077515.
    KOiK01937.
    OMAiSVNIKYI.
    OrthoDBiEOG6RC3NR.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_01227. PyrG.
    InterProiIPR029062. Class_I_gatase-like.
    IPR004468. CTP_synthase.
    IPR017456. CTP_synthase_N.
    IPR017926. GATASE.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11550. PTHR11550. 1 hit.
    PfamiPF06418. CTP_synth_N. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00337. PyrG. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92I97-1 [UniParc]FASTAAdd to Basket

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    MVHFIFVTGG VVSSLGKGLT AASLAMLLQA KGFRVSVRKL DPYLNIDPGT    50
    MNPHEHGEVY VTDDGAETDL DLGHYERFTG VSACKFDSIT TGAIYSKLLK 100
    DERLGNYAGV TVQVIPHVTN IIKDFILSNT KGFDFIICEI GGTVGDIEGL 150
    PFFEAIRQIG NKLKSENCLF IHLTLLPYVK TARELKIKPT QHSVKALRAI 200
    GISPNILVCR AERNISKGEI DKISLLCNIE SEYVVPAIDQ KNIYLVPIAY 250
    HNSGLDNKVL KFFNINIMPS KLDKWHDIIN RLKDSNSKVR IAIIAKYHKL 300
    KDAYKSVIEA LDHAGIYYKY KIDLVWINAE NLTEENINKK LLDIDGILVP 350
    GGFGERATKG TIIAIKYART NNIPFFGICF GMQLATIEIA QNLIGIKDAV 400
    TEEFKVDGTK IIEKINKNCE DSKITIENVK KTMRLGSYPC SLVASTIAAN 450
    AYKSLEINER HRHRYKFNNE FQNIFEKHGI VFSGFSKDEE IVEIIELPLL 500
    RWFVGVQFHP EFKSKPFEAH PLFIQFIKAA IEYNKCN 537
    Length:537
    Mass (Da):60,451
    Last modified:December 1, 2001 - v1
    Checksum:i42DD5159B7A20680
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03061.1.
    PIRiC97765.
    RefSeqiNP_360160.1. NC_003103.1.
    WP_010977162.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03061; AAL03061; RC0523.
    GeneIDi928731.
    KEGGirco:RC0523.
    PATRICi17888290. VBIRicCon45613_0598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03061.1 .
    PIRi C97765.
    RefSeqi NP_360160.1. NC_003103.1.
    WP_010977162.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92I97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0523.

    Proteomic databases

    PRIDEi Q92I97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03061 ; AAL03061 ; RC0523 .
    GeneIDi 928731.
    KEGGi rco:RC0523.
    PATRICi 17888290. VBIRicCon45613_0598.

    Phylogenomic databases

    eggNOGi COG0504.
    HOGENOMi HOG000077515.
    KOi K01937.
    OMAi SVNIKYI.
    OrthoDBi EOG6RC3NR.

    Enzyme and pathway databases

    UniPathwayi UPA00159 ; UER00277 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_01227. PyrG.
    InterProi IPR029062. Class_I_gatase-like.
    IPR004468. CTP_synthase.
    IPR017456. CTP_synthase_N.
    IPR017926. GATASE.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11550. PTHR11550. 1 hit.
    Pfami PF06418. CTP_synth_N. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00337. PyrG. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiPYRG_RICCN
    AccessioniPrimary (citable) accession number: Q92I97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3