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Q92I97 (PYRG_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTP synthase

EC=6.3.4.2
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene names
Name:pyrG
Ordered Locus Names:RC0523
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP-Rule MF_01227

Catalytic activity

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate. HAMAP-Rule MF_01227

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP-Rule MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP-Rule MF_01227

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01227

Sequence similarities

Belongs to the CTP synthase family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' CTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

CTP synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537CTP synthase HAMAP-Rule MF_01227
PRO_0000138216

Regions

Domain290 – 536247Glutamine amidotransferase type-1
Region1 – 252252Aminator domain HAMAP-Rule MF_01227

Sites

Active site3791Nucleophile By similarity
Active site5091 By similarity
Active site5111 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92I97 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 42DD5159B7A20680

FASTA53760,451
        10         20         30         40         50         60 
MVHFIFVTGG VVSSLGKGLT AASLAMLLQA KGFRVSVRKL DPYLNIDPGT MNPHEHGEVY 

        70         80         90        100        110        120 
VTDDGAETDL DLGHYERFTG VSACKFDSIT TGAIYSKLLK DERLGNYAGV TVQVIPHVTN 

       130        140        150        160        170        180 
IIKDFILSNT KGFDFIICEI GGTVGDIEGL PFFEAIRQIG NKLKSENCLF IHLTLLPYVK 

       190        200        210        220        230        240 
TARELKIKPT QHSVKALRAI GISPNILVCR AERNISKGEI DKISLLCNIE SEYVVPAIDQ 

       250        260        270        280        290        300 
KNIYLVPIAY HNSGLDNKVL KFFNINIMPS KLDKWHDIIN RLKDSNSKVR IAIIAKYHKL 

       310        320        330        340        350        360 
KDAYKSVIEA LDHAGIYYKY KIDLVWINAE NLTEENINKK LLDIDGILVP GGFGERATKG 

       370        380        390        400        410        420 
TIIAIKYART NNIPFFGICF GMQLATIEIA QNLIGIKDAV TEEFKVDGTK IIEKINKNCE 

       430        440        450        460        470        480 
DSKITIENVK KTMRLGSYPC SLVASTIAAN AYKSLEINER HRHRYKFNNE FQNIFEKHGI 

       490        500        510        520        530 
VFSGFSKDEE IVEIIELPLL RWFVGVQFHP EFKSKPFEAH PLFIQFIKAA IEYNKCN 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03061.1.
PIRC97765.
RefSeqNP_360160.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0523.

Proteomic databases

PRIDEQ92I97.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03061; AAL03061; RC0523.
GeneID928731.
KEGGrco:RC0523.
PATRIC17888290. VBIRicCon45613_0598.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0504.
HOGENOMHOG000077515.
KOK01937.
OMASVNIKYI.
OrthoDBEOG6RC3NR.

Enzyme and pathway databases

UniPathwayUPA00159; UER00277.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPMF_01227. PyrG.
InterProIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11550. PTHR11550. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRG_RICCN
AccessionPrimary (citable) accession number: Q92I97
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways