Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92I96 (KDSB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase

EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:RC0524
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP-Rule MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP-Rule MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP-Rule MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00057

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processCMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2462463-deoxy-manno-octulosonate cytidylyltransferase HAMAP-Rule MF_00057
PRO_0000188513

Sequences

Sequence LengthMass (Da)Tools
Q92I96 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 511C7D5C2E2B46C6

FASTA24627,476
        10         20         30         40         50         60 
MRHQDVAIII PSRLSSTRLK QKPLQLIGSI TLIERVFKQV NQAGLEHTYV ATDSEEIASV 

        70         80         90        100        110        120 
ITKVGGKVIF TDSAIPTGTD RTYEAFKLIP NNQNINYIVN VQGDMPFIEP SSILKIIEYL 

       130        140        150        160        170        180 
KNSKYDVVTP IVKVDRESVK ASSNVTVAVD SAGTALYFSR SLIPNGAEEF LYHVGMYGFR 

       190        200        210        220        230        240 
KNALEKFVSL KPTFLEKTER LEQLRVLENG MTIGTCLVEN VPISVDTEED LKKAVKFYEN 


ISKLGL 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03062.1.
PIRD97765.
RefSeqNP_360161.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0524.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03062; AAL03062; RC0524.
GeneID927639.
KEGGrco:RC0524.
PATRIC17888292. VBIRicCon45613_0599.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1212.
HOGENOMHOG000007602.
KOK00979.
OMADDQRIAD.
OrthoDBEOG6KT2SK.

Enzyme and pathway databases

BRENDA2.7.7.38. 5446.
UniPathwayUPA00030.
UPA00358; UER00476.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
HAMAPMF_00057. CMP_KDO_synth.
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
TIGRFAMsTIGR00466. kdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_RICCN
AccessionPrimary (citable) accession number: Q92I96
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways