Q92I96 (KDSB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase

Gene names

Name:	kdsB
Ordered Locus Names:	RC0524

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP-Rule MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP-Rule MF_00057
Pathway	Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP-Rule MF_00057 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00057
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00057.
Sequence similarities	Belongs to the KdsB family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	3-deoxy-manno-octulosonate cytidylyltransferase HAMAP-Rule MF_00057		PRO_0000188513

Sequences

	Sequence		Length	Mass (Da)
	Q92I96 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 511C7D5C2E2B46C6	FASTA	246	27,476
	10 20 30 40 50 60 MRHQDVAIII PSRLSSTRLK QKPLQLIGSI TLIERVFKQV NQAGLEHTYV ATDSEEIASV 70 80 90 100 110 120 ITKVGGKVIF TDSAIPTGTD RTYEAFKLIP NNQNINYIVN VQGDMPFIEP SSILKIIEYL 130 140 150 160 170 180 KNSKYDVVTP IVKVDRESVK ASSNVTVAVD SAGTALYFSR SLIPNGAEEF LYHVGMYGFR 190 200 210 220 230 240 KNALEKFVSL KPTFLEKTER LEQLRVLENG MTIGTCLVEN VPISVDTEED LKKAVKFYEN ISKLGL

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03062.1.
PIR	D97765.
RefSeq	NP_360161.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92I96.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0524.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03062; AAL03062; RC0524.
GeneID	927639.
KEGG	rco:RC0524.
PATRIC	17888292. VBIRicCon45613_0599.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1212.
HOGENOM	HOG000007602.
KO	K00979.
OMA	NSGTERC.
ProtClustDB	PRK05450.
Enzyme and pathway databases
BRENDA	2.7.7.38. 5446.
UniPathway	UPA00030. UPA00358; UER00476.
Family and domain databases
HAMAP	MF_00057. CMP-KDO_synth.
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
PANTHER	PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. kdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSB_RICCN

Accession

Primary (citable) accession number: Q92I96

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program