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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-872-MONOMER
BRENDAi2.7.7.38 5446
UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
Ordered Locus Names:RC0524
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001885131 – 2463-deoxy-manno-octulosonate cytidylyltransferaseAdd BLAST246

Proteomic databases

PRIDEiQ92I96

Structurei

3D structure databases

ProteinModelPortaliQ92I96
SMRiQ92I96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000007602
KOiK00979
OMAiNSGTERC
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

Q92I96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHQDVAIII PSRLSSTRLK QKPLQLIGSI TLIERVFKQV NQAGLEHTYV
60 70 80 90 100
ATDSEEIASV ITKVGGKVIF TDSAIPTGTD RTYEAFKLIP NNQNINYIVN
110 120 130 140 150
VQGDMPFIEP SSILKIIEYL KNSKYDVVTP IVKVDRESVK ASSNVTVAVD
160 170 180 190 200
SAGTALYFSR SLIPNGAEEF LYHVGMYGFR KNALEKFVSL KPTFLEKTER
210 220 230 240
LEQLRVLENG MTIGTCLVEN VPISVDTEED LKKAVKFYEN ISKLGL
Length:246
Mass (Da):27,476
Last modified:December 1, 2001 - v1
Checksum:i511C7D5C2E2B46C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03062.1
PIRiD97765
RefSeqiWP_010977163.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03062; AAL03062; RC0524
GeneIDi927639
KEGGirco:RC0524
PATRICifig|272944.4.peg.599

Similar proteinsi

Entry informationi

Entry nameiKDSB_RICCN
AccessioniPrimary (citable) accession number: Q92I96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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