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Q92I96

- KDSB_RICCN

UniProt

Q92I96 - KDSB_RICCN

Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

    Catalytic activityi

    CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
    2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BRENDAi2.7.7.38. 5446.
    UniPathwayiUPA00030.
    UPA00358; UER00476.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
    Alternative name(s):
    CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
    Short name:
    CKSUniRule annotation
    Short name:
    CMP-KDO synthaseUniRule annotation
    Gene namesi
    Name:kdsBUniRule annotation
    Ordered Locus Names:RC0524
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2462463-deoxy-manno-octulosonate cytidylyltransferasePRO_0000188513Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92I96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KdsB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1212.
    HOGENOMiHOG000007602.
    KOiK00979.
    OMAiDDQRIAD.
    OrthoDBiEOG6KT2SK.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_00057. CMP_KDO_synth.
    InterProiIPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
    PfamiPF02348. CTP_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR00466. kdsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92I96-1 [UniParc]FASTAAdd to Basket

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    MRHQDVAIII PSRLSSTRLK QKPLQLIGSI TLIERVFKQV NQAGLEHTYV    50
    ATDSEEIASV ITKVGGKVIF TDSAIPTGTD RTYEAFKLIP NNQNINYIVN 100
    VQGDMPFIEP SSILKIIEYL KNSKYDVVTP IVKVDRESVK ASSNVTVAVD 150
    SAGTALYFSR SLIPNGAEEF LYHVGMYGFR KNALEKFVSL KPTFLEKTER 200
    LEQLRVLENG MTIGTCLVEN VPISVDTEED LKKAVKFYEN ISKLGL 246
    Length:246
    Mass (Da):27,476
    Last modified:December 1, 2001 - v1
    Checksum:i511C7D5C2E2B46C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03062.1.
    PIRiD97765.
    RefSeqiNP_360161.1. NC_003103.1.
    WP_010977163.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03062; AAL03062; RC0524.
    GeneIDi927639.
    KEGGirco:RC0524.
    PATRICi17888292. VBIRicCon45613_0599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03062.1 .
    PIRi D97765.
    RefSeqi NP_360161.1. NC_003103.1.
    WP_010977163.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92I96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0524.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03062 ; AAL03062 ; RC0524 .
    GeneIDi 927639.
    KEGGi rco:RC0524.
    PATRICi 17888292. VBIRicCon45613_0599.

    Phylogenomic databases

    eggNOGi COG1212.
    HOGENOMi HOG000007602.
    KOi K00979.
    OMAi DDQRIAD.
    OrthoDBi EOG6KT2SK.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00358 ; UER00476 .
    BRENDAi 2.7.7.38. 5446.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    HAMAPi MF_00057. CMP_KDO_synth.
    InterProi IPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
    Pfami PF02348. CTP_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR00466. kdsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiKDSB_RICCN
    AccessioniPrimary (citable) accession number: Q92I96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3