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Q92I67 (COX1_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Synonyms:coxA
Ordered Locus Names:RC0553
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Probable cytochrome c oxidase subunit 1
PRO_0000183448

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane355 – 37521Helical; Potential
Transmembrane394 – 41421Helical; Potential
Transmembrane431 – 45121Helical; Potential
Transmembrane473 – 49321Helical; Potential

Sites

Metal binding791Iron (heme A axial ligand) By similarity
Metal binding2581Copper B By similarity
Metal binding2621Copper B By similarity
Metal binding3071Copper B By similarity
Metal binding3081Copper B By similarity
Metal binding3931Iron (heme A3 axial ligand) By similarity
Metal binding3951Iron (heme A axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92I67 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9928AA8C8F6E9991

FASTA53258,877
        10         20         30         40         50         60 
MDITTTEIYH DGHHTPHGWR RWLFSTNHKD IGIMYIIFAV FAGIVGGLFS LLFRLELAMP 

        70         80         90        100        110        120 
GGTFLNHDFQ LYNVLITAHA VIMVFFMIMP ALFGGFGNYF VPLLIGAPDM AFPRLNNISF 

       130        140        150        160        170        180 
WLLVPAFLLL MGSAFVDGGP GTGWTLYPPL SNLSGHPGAA VDMAIFSLHL TGLSSILGSI 

       190        200        210        220        230        240 
NLIVTIFNMR APGMGLFKMP LFVWSILVTA FLIILAMPVL GGAITMLLTD RNFGTTFFKP 

       250        260        270        280        290        300 
DGGGDPVLFQ HLFWFFGHPE VYIVILPGFG IVSQVISTFS RKPIFGYQGM IGAMVIIGFV 

       310        320        330        340        350        360 
GFIVWAHHMF TVGLSYNALI YFTAGTMIIA VPTGIKIFSW IATMWGGSIT FPTPMLFSIG 

       370        380        390        400        410        420 
FIILFTIGGV TGIILSNSAL DRVLHDTYYV VAHFHYTMSL GALFTAFAGF YYWFGKISGK 

       430        440        450        460        470        480 
QYPDILGKIH FWITFIGVNL TFFPQHFLGL AGMPRRIPDY PEAFAGWNMV SSIGAGISMF 

       490        500        510        520        530 
AALYFVFIVF YTLKYGKDCP NNPWGEGADT LEWTLTSPPP FHTFETPPHI EG 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03091.1.
PIRA97769.
RefSeqNP_360190.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I67.
SMRQ92I67. Positions 21-531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03091; AAL03091; RC0553.
GeneID928758.
KEGGrco:RC0553.
PATRIC17888362. VBIRicCon45613_0632.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02274.
OMAVNGAFGN.
OrthoDBEOG6B35XR.
ProtClustDBCLSK870907.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_RICCN
AccessionPrimary (citable) accession number: Q92I67
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways