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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi235Copper ASequence analysis1
Metal bindingi270Copper ASequence analysis1
Metal bindingi274Copper ASequence analysis1
Metal bindingi278Copper ASequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-927-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RC0555
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837191 – 315Probable cytochrome c oxidase subunit 2Add BLAST315

Structurei

3D structure databases

ProteinModelPortaliQ92I65
SMRiQ92I65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988
KOiK02275
OMAiHAFMPIA
OrthoDBiPOG091H05L4

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
IPR005728 Rickett_RPE
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
TIGR01045 RPE1, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q92I65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNIIRHFSK PAYREEFKED TSPRTAEYKS VSEDSSTGLT YTLPPKAKFG
60 70 80 90 100
KMSIALICFL IVSCNCFASE PLPWQVTFQP PASPIMEELH HFHNFLLYIS
110 120 130 140 150
TAIVLFVAGL LGFVCIRFNA KNNPVPAKFS HNVLIEIIWT VIPIIILVII
160 170 180 190 200
AVPSFKILRH AEKIPKTDLT IKVVGYQWYW HYIYPDHDNL EFDSVMISDE
210 220 230 240 250
NLKPNHKRLL DVDNRIVIPE NATVRFLITA GDVIHSFAVP SLGFKIDAVP
260 270 280 290 300
GRINETWTRV AKKGVYYGQC SELCGIHHGF MPIAIEVVSK EDFDNWIASK
310
NKTAMNGKKP KLVAN
Length:315
Mass (Da):35,744
Last modified:December 1, 2001 - v1
Checksum:iCBFD01EED5FF30E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03093.1
PIRiC97769
RefSeqiWP_010977191.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03093; AAL03093; RC0555
GeneIDi927663
KEGGirco:RC0555
PATRICifig|272944.4.peg.634

Similar proteinsi

Entry informationi

Entry nameiCOX2_RICCN
AccessioniPrimary (citable) accession number: Q92I65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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