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Q92I65 (COX2_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Synonyms:coxB
Ordered Locus Names:RC0555
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Probable cytochrome c oxidase subunit 2
PRO_0000183719

Regions

Transmembrane54 – 7421Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane133 – 15321Helical; Potential

Sites

Metal binding2351Copper A Potential
Metal binding2701Copper A Potential
Metal binding2741Copper A Potential
Metal binding2781Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q92I65 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: CBFD01EED5FF30E4

FASTA31535,744
        10         20         30         40         50         60 
MKNIIRHFSK PAYREEFKED TSPRTAEYKS VSEDSSTGLT YTLPPKAKFG KMSIALICFL 

        70         80         90        100        110        120 
IVSCNCFASE PLPWQVTFQP PASPIMEELH HFHNFLLYIS TAIVLFVAGL LGFVCIRFNA 

       130        140        150        160        170        180 
KNNPVPAKFS HNVLIEIIWT VIPIIILVII AVPSFKILRH AEKIPKTDLT IKVVGYQWYW 

       190        200        210        220        230        240 
HYIYPDHDNL EFDSVMISDE NLKPNHKRLL DVDNRIVIPE NATVRFLITA GDVIHSFAVP 

       250        260        270        280        290        300 
SLGFKIDAVP GRINETWTRV AKKGVYYGQC SELCGIHHGF MPIAIEVVSK EDFDNWIASK 

       310 
NKTAMNGKKP KLVAN 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03093.1.
PIRC97769.
RefSeqNP_360192.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0555.

Proteomic databases

PRIDEQ92I65.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03093; AAL03093; RC0555.
GeneID927663.
KEGGrco:RC0555.
PATRIC17888366. VBIRicCon45613_0634.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.
KOK02275.
OMASKNKTAM.
OrthoDBEOG68SVXT.
ProtClustDBCLSK870908.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR005728. Rickett_RPE.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_RICCN
AccessionPrimary (citable) accession number: Q92I65
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names