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Q92I37 (DPO3B_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase III subunit beta

EC=2.7.7.7
Gene names
Name:dnaN
Ordered Locus Names:RC0583
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Subcellular location

Cytoplasm By similarity.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379DNA polymerase III subunit beta
PRO_0000105457

Sequences

Sequence LengthMass (Da)Tools
Q92I37 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1FBE1A62CE25639C

FASTA37942,237
        10         20         30         40         50         60 
MLKLIVETKT LVQSLGFASS VVEKRNVIPE YANIKLSAKD GNLELSSTNM DLYLSQKIAV 

        70         80         90        100        110        120 
QVVSEGECTV STKTLNDIVR KLPDSELTLT DLGTTGLEIK GKNCKFNLFT LPVSSFPAMD 

       130        140        150        160        170        180 
SINPEASFKI SCTDFAKIIE STKFSISLDE TRYNLNGVYL HIKDKEFCSA STDGHRLSIS 

       190        200        210        220        230        240 
WVTLEKQIKN FGVILPQKSA EEILKIVKDP KNINEDIEIL LSSNKIKFIC NENTSMLSKL 

       250        260        270        280        290        300 
IDGTFPDYST FIPESSSSKL VINRKMFADS IERIAIITVE KFRAVKLSLS RETLEISAVG 

       310        320        330        340        350        360 
EARGNAKEVI NSSQDKESFY EYNSDESLAI GFNPQYLEDV LKAVKSDVVE LYFSDVSAPV 

       370 
LIKFPENPKD IFVVMPVKV 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03121.1.
PIRG97772.
RefSeqNP_360220.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03121; AAL03121; RC0583.
GeneID927682.
KEGGrco:RC0583.
PATRIC17888428. VBIRicCon45613_0665.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0592.
HOGENOMHOG000071791.
KOK02338.
OMAAVCSMPV.
OrthoDBEOG65J53F.

Family and domain databases

InterProIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00663. dnan. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPO3B_RICCN
AccessionPrimary (citable) accession number: Q92I37
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia conorii

(strain Malish 7): entries and gene names