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Q92I35

- SYL_RICCN

UniProt

Q92I35 - SYL_RICCN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei605 – 6051ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RC0585
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Leucine--tRNA ligasePRO_0000152074Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0585.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92I35.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi602 – 6065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92I35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQIEQKWQY IWQEEKAFEV SNASSKPKYY VLEMLPYPSG KIHVGHVRNY    50
    SIGDVIARFM TMQGFNVLHP MGWDAFGLPA ENAAIKNNSH PKKWTYSNIK 100
    NMKKQLKSMG FSYDWSREIN SCDPEYYKHE QKFFLELYER NLAYQKESFV 150
    NWDPVDNTVL ANEQVVDGRG WRSGAIVVKR YLKQWFLKIT DYAEELLNEI 200
    QNLKEWPEAV RSMQEKWIGK SIGANFHFKI KDNEETTIEV FSTKPETIFG 250
    ASFIGIAFNH PIIERLVSKT PEILAFITQC SHITRSSELE KAEKEGVFTG 300
    LFVTHPFDSN IVLPVIITNF VLMDYGTGAI FGCPAHDECD HELAVKMNLS 350
    IKQVIKADMD VQKTAYTEDG ILINSDFLNG LTSNEAKQEV IGEFEKLGIG 400
    KRSVNYRLKD WGISRQRFWG CPIPMIHCEI CGIVPVPYKD LPVTLPDDVN 450
    FDGHGNPLDH HPSWKHVNCP KCDKPAVRET DTFDTFFESS WYFTRYCNSN 500
    ATEMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQNYVSVRE 550
    PFKGLFTQGM VLHATYKDEH NNWLYPEEVV KKGNEFFHKE SNNRVVQGRI 600
    EKMSKSKKNL IDLETMQEQY GADAIRLFVL SDSPPEKDLE WSASGIEGCS 650
    RFINKLEYMF KAIDSLKDDV NSEVNKELNR LVHFTIKHVA EDIKHFALNR 700
    AIARMRELSN AISAEISKDK IDVKTVRHGF NVLVQLLNPF IPHITEEIWQ 750
    KLGNKERLYN LSFPAFDESM LELDTYIMAV QVNGKLRDTY EFKTSVSEDE 800
    IKQVTVSLPK VQKFLEGKEP KKIILVPRKI VNILV 835
    Length:835
    Mass (Da):96,589
    Last modified:December 1, 2001 - v1
    Checksum:iCAA69066F268CB67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03123.1.
    PIRiA97773.
    RefSeqiNP_360222.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03123; AAL03123; RC0585.
    GeneIDi928773.
    KEGGirco:RC0585.
    PATRICi17888438. VBIRicCon45613_0670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03123.1 .
    PIRi A97773.
    RefSeqi NP_360222.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92I35.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03123 ; AAL03123 ; RC0585 .
    GeneIDi 928773.
    KEGGi rco:RC0585.
    PATRICi 17888438. VBIRicCon45613_0670.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiSYL_RICCN
    AccessioniPrimary (citable) accession number: Q92I35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3