Reviewed, UniProtKB/Swiss-Prot Q92I31 (CDSA_RICCN)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	RC0589

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Phosphatidate cytidylyltransferase		PRO_0000281057
Regions
	Transmembrane	33 – 53	21	Potential
	Transmembrane	67 – 87	21	Potential
	Transmembrane	95 – 115	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	167 – 187	21	Potential
	Transmembrane	206 – 226	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92I31-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0622FC437489188D	FASTA	230	26,126
	10 20 30 40 50 60 MITQKGKEHL VKDKQKSNIY LRILSGIVLV PLFVIAILWC KPLFYILMIL VGTGMLSEWY 70 80 90 100 110 120 NMTYSSIPDL LIGLIIIPIP ISLLIFLSME DTNRWLIMLY FCIMWSVDTF AMIGGKTFKG 130 140 150 160 170 180 AKLAPKLSPK KTWSGLVTGV LSAGLVAVLV SFIPNFHIEN YYFSNKIYLF IISCILALIA 190 200 210 220 230 QLSDLFISYF KRKFNIKDSG HIIPGHGGVL DRFDSIILTT LILFLMKIYL

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL03127.1.
PIR	E97773.
RefSeq	NP_360226.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	927687.
GenomeReviews	Gene locus RC0589 in contig AE006914_GR.
KEGG	rco:RC0589.
NMPDR	fig|272944.1.peg.589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92I31.
OMA	MEDTNRW.
Enzyme and pathway databases
BioCyc	RCON272944:RC0589-MON.
BRENDA	2.7.7.41. 267518.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_RICCN

Accession

Primary (citable) accession number: Q92I31

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)