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Q92I31

- CDSA_RICCN

UniProt

Q92I31 - CDSA_RICCN

Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:cdsA
    Ordered Locus Names:RC0589
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230Phosphatidate cytidylyltransferasePRO_0000281057Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0589.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    HOGENOMiHOG000006169.
    KOiK00981.
    OMAiLNPMLEN.
    OrthoDBiEOG6TBHJT.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92I31-1 [UniParc]FASTAAdd to Basket

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    MITQKGKEHL VKDKQKSNIY LRILSGIVLV PLFVIAILWC KPLFYILMIL    50
    VGTGMLSEWY NMTYSSIPDL LIGLIIIPIP ISLLIFLSME DTNRWLIMLY 100
    FCIMWSVDTF AMIGGKTFKG AKLAPKLSPK KTWSGLVTGV LSAGLVAVLV 150
    SFIPNFHIEN YYFSNKIYLF IISCILALIA QLSDLFISYF KRKFNIKDSG 200
    HIIPGHGGVL DRFDSIILTT LILFLMKIYL 230
    Length:230
    Mass (Da):26,126
    Last modified:December 1, 2001 - v1
    Checksum:i0622FC437489188D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03127.1.
    PIRiE97773.
    RefSeqiNP_360226.1. NC_003103.1.
    WP_010977221.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03127; AAL03127; RC0589.
    GeneIDi927687.
    KEGGirco:RC0589.
    PATRICi17888448. VBIRicCon45613_0675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03127.1 .
    PIRi E97773.
    RefSeqi NP_360226.1. NC_003103.1.
    WP_010977221.1. NC_003103.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03127 ; AAL03127 ; RC0589 .
    GeneIDi 927687.
    KEGGi rco:RC0589.
    PATRICi 17888448. VBIRicCon45613_0675.

    Phylogenomic databases

    eggNOGi COG0575.
    HOGENOMi HOG000006169.
    KOi K00981.
    OMAi LNPMLEN.
    OrthoDBi EOG6TBHJT.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .

    Family and domain databases

    InterProi IPR000374. PC_trans.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiCDSA_RICCN
    AccessioniPrimary (citable) accession number: Q92I31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3