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Q92I26 (ILVE_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable branched-chain-amino-acid aminotransferase

Short name=BCAT
EC=2.6.1.42
Gene names
Name:ilvE
Ordered Locus Names:RC0594
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts on leucine, isoleucine and valine By similarity.

Catalytic activity

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.

L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.

Sequence similarities

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Probable branched-chain-amino-acid aminotransferase
PRO_0000103275

Amino acid modifications

Modified residue1551N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92I26 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 86112A254A505177

FASTA29033,243
        10         20         30         40         50         60 
MTMVKLEQIF WHVWINGDLV PYQFARIHVL THSLHYSGSV FEGERAYNGK VFKLKEHTAR 

        70         80         90        100        110        120 
LIKSAEALGL KVPYNVDEII KAHECVIKQN NIKDAYIRPL IWCGDESLNI TNQYLSTNLL 

       130        140        150        160        170        180 
IAGIPSMPRS FEKGINLHVS RWRKAMPDST PVQSKSAAQY NMAITSKKEA KALGYEDALL 

       190        200        210        220        230        240 
LDYEGYIAEC TTTNIFFVKD KILYTPIADR FLNGITRQTI IEIAKDLGLE VKEERLKLEQ 

       250        260        270        280        290 
IEDFTGCFVT GTAIEVQNID SIDLGNKKII FDDHKIADRL KEEYRRVVRE 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03132.1.
PIRB97774.
RefSeqNP_360231.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0594.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03132; AAL03132; RC0594.
GeneID927689.
KEGGrco:RC0594.
PATRIC17888456. VBIRicCon45613_0679.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0115.
HOGENOMHOG000276706.
KOK00826.
OMADWEDNVA.
OrthoDBEOG67MF3R.
ProtClustDBPRK06606.

Enzyme and pathway databases

UniPathwayUPA00047; UER00058.
UPA00048; UER00073.
UPA00049; UER00062.

Family and domain databases

InterProIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005785. B_amino_transI.
[Graphical view]
PANTHERPTHR11825. PTHR11825. 1 hit.
PfamPF01063. Aminotran_4. 1 hit.
[Graphical view]
SUPFAMSSF56752. SSF56752. 1 hit.
TIGRFAMsTIGR01122. ilvE_I. 1 hit.
PROSITEPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVE_RICCN
AccessionPrimary (citable) accession number: Q92I26
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: November 13, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways