Q92I26 (ILVE_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable branched-chain-amino-acid aminotransferase
Short name=BCAT
EC=2.6.1.42

Gene names

Name:	ilvE
Ordered Locus Names:	RC0594

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts on leucine, isoleucine and valine By similarity.
Catalytic activity	L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate. L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4. Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.
Sequence similarities	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway leucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway valine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	L-isoleucine transaminase activity Inferred from electronic annotation. Source: EC L-leucine transaminase activity Inferred from electronic annotation. Source: EC L-valine transaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Probable branched-chain-amino-acid aminotransferase		PRO_0000103275
Amino acid modifications
	Modified residue	155	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92I26 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 86112A254A505177	FASTA	290	33,243
	10 20 30 40 50 60 MTMVKLEQIF WHVWINGDLV PYQFARIHVL THSLHYSGSV FEGERAYNGK VFKLKEHTAR 70 80 90 100 110 120 LIKSAEALGL KVPYNVDEII KAHECVIKQN NIKDAYIRPL IWCGDESLNI TNQYLSTNLL 130 140 150 160 170 180 IAGIPSMPRS FEKGINLHVS RWRKAMPDST PVQSKSAAQY NMAITSKKEA KALGYEDALL 190 200 210 220 230 240 LDYEGYIAEC TTTNIFFVKD KILYTPIADR FLNGITRQTI IEIAKDLGLE VKEERLKLEQ 250 260 270 280 290 IEDFTGCFVT GTAIEVQNID SIDLGNKKII FDDHKIADRL KEEYRRVVRE

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03132.1.
PIR	B97774.
RefSeq	NP_360231.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92I26.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0594.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03132; AAL03132; RC0594.
GeneID	927689.
KEGG	rco:RC0594.
PATRIC	17888456. VBIRicCon45613_0679.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0115.
HOGENOM	HOG000276706.
KO	K00826.
OMA	MKGIRLD.
ProtClustDB	PRK06606.
Enzyme and pathway databases
UniPathway	UPA00047; UER00058. UPA00048; UER00073. UPA00049; UER00062.
Family and domain databases
InterPro	IPR001544. Aminotrans_IV. IPR018300. Aminotrans_IV_CS. IPR005785. B_amino_transI. [Graphical view]
PANTHER	PTHR11825. PTHR11825. 1 hit.
Pfam	PF01063. Aminotran_4. 1 hit. [Graphical view]
SUPFAM	SSF56752. Aminotrans_IV. 1 hit.
TIGRFAMs	TIGR01122. ilvE_I. 1 hit.
PROSITE	PS00770. AA_TRANSFER_CLASS_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ILVE_RICCN

Accession

Primary (citable) accession number: Q92I26

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program