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Q92I26

- ILVE_RICCN

UniProt

Q92I26 - ILVE_RICCN

Protein

Probable branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acts on leucine, isoleucine and valine.By similarity

    Catalytic activityi

    L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
    L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
    L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. L-isoleucine transaminase activity Source: UniProtKB-EC
    2. L-leucine transaminase activity Source: UniProtKB-EC
    3. L-valine transaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. leucine biosynthetic process Source: UniProtKB-UniPathway
    3. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00058.
    UPA00048; UER00073.
    UPA00049; UER00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable branched-chain-amino-acid aminotransferase (EC:2.6.1.42)
    Short name:
    BCAT
    Gene namesi
    Name:ilvE
    Ordered Locus Names:RC0594
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Probable branched-chain-amino-acid aminotransferasePRO_0000103275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei155 – 1551N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0594.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92I26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0115.
    HOGENOMiHOG000276706.
    KOiK00826.
    OMAiDGEIYTT.
    OrthoDBiEOG67MF3R.

    Family and domain databases

    InterProiIPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005785. B_amino_transI.
    [Graphical view]
    PANTHERiPTHR11825. PTHR11825. 1 hit.
    PfamiPF01063. Aminotran_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF56752. SSF56752. 1 hit.
    TIGRFAMsiTIGR01122. ilvE_I. 1 hit.
    PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92I26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMVKLEQIF WHVWINGDLV PYQFARIHVL THSLHYSGSV FEGERAYNGK    50
    VFKLKEHTAR LIKSAEALGL KVPYNVDEII KAHECVIKQN NIKDAYIRPL 100
    IWCGDESLNI TNQYLSTNLL IAGIPSMPRS FEKGINLHVS RWRKAMPDST 150
    PVQSKSAAQY NMAITSKKEA KALGYEDALL LDYEGYIAEC TTTNIFFVKD 200
    KILYTPIADR FLNGITRQTI IEIAKDLGLE VKEERLKLEQ IEDFTGCFVT 250
    GTAIEVQNID SIDLGNKKII FDDHKIADRL KEEYRRVVRE 290
    Length:290
    Mass (Da):33,243
    Last modified:December 1, 2001 - v1
    Checksum:i86112A254A505177
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03132.1.
    PIRiB97774.
    RefSeqiNP_360231.1. NC_003103.1.
    WP_010977226.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03132; AAL03132; RC0594.
    GeneIDi927689.
    KEGGirco:RC0594.
    PATRICi17888456. VBIRicCon45613_0679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03132.1 .
    PIRi B97774.
    RefSeqi NP_360231.1. NC_003103.1.
    WP_010977226.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92I26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03132 ; AAL03132 ; RC0594 .
    GeneIDi 927689.
    KEGGi rco:RC0594.
    PATRICi 17888456. VBIRicCon45613_0679.

    Phylogenomic databases

    eggNOGi COG0115.
    HOGENOMi HOG000276706.
    KOi K00826.
    OMAi DGEIYTT.
    OrthoDBi EOG67MF3R.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00058 .
    UPA00048 ; UER00073 .
    UPA00049 ; UER00062 .

    Family and domain databases

    InterProi IPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005785. B_amino_transI.
    [Graphical view ]
    PANTHERi PTHR11825. PTHR11825. 1 hit.
    Pfami PF01063. Aminotran_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56752. SSF56752. 1 hit.
    TIGRFAMsi TIGR01122. ilvE_I. 1 hit.
    PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiILVE_RICCN
    AccessioniPrimary (citable) accession number: Q92I26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3