Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109NAD; via amide nitrogenUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei141NAD; via amide nitrogenUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1
Binding sitei258NADUniRule annotation1
Binding sitei284NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-1030-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:RC0615
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380161 – 325Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST325

Structurei

3D structure databases

ProteinModelPortaliQ92I05
SMRiQ92I05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 259Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246854
KOiK00057
OMAiWLCKGFE
OrthoDBiPOG091H060E

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q92I05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKFKNIAVY GGGSFGTSLA SLAAQNCNNV TLFLRDEAIA KEILHNKTNV
60 70 80 90 100
KYLGDIKLPA HLQATTNLDI IKDFELIIIA LPSYAFDDSI KLLKTHSISK
110 120 130 140 150
DNTLLIATKG FARNPTALLS DRLKTLLPYN PTAFFVGPNL AKELAKNLPA
160 170 180 190 200
SASIASLDID IANKIAYNLS SKIFTTNVSS DIVTLQVAGA LKNIFAIKSG
210 220 230 240 250
IDLARKQGEN ARATLIVAAL KEIAILSKAL GGMQKNSDIL LEGVVGDLVL
260 270 280 290 300
TCYSLGSRNT KFGYELGISS DKKKFLQEYK ELAEGREALK LVLDLIKKYN
310 320
LHMPIISEVA SCVIPYVIPA KAGMT
Length:325
Mass (Da):35,161
Last modified:December 1, 2001 - v1
Checksum:i06118DB2B9B7F71D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03153.1
PIRiG97776
RefSeqiWP_010977245.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03153; AAL03153; RC0615
GeneIDi927704
KEGGirco:RC0615
PATRICifig|272944.4.peg.700

Similar proteinsi

Entry informationi

Entry nameiGPDA_RICCN
AccessioniPrimary (citable) accession number: Q92I05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health