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Q92I05 (GPDA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
EC=1.1.1.94
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene names
Name:gpsA
Ordered Locus Names:RC0615
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group ›

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP-Rule MF_00394

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP-Rule MF_00394

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Glycerol-3-phosphate dehydrogenase [NAD(P)+] HAMAP-Rule MF_00394
PRO_0000138016

Regions

Nucleotide binding11 – 166NAD By similarity
Region258 – 2592Substrate binding By similarity

Sites

Active site1921Proton acceptor By similarity
Binding site1091NAD; via amide nitrogen By similarity
Binding site1091Substrate By similarity
Binding site1411NAD; via amide nitrogen By similarity
Binding site2581NAD By similarity
Binding site2841NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92I05 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 06118DB2B9B7F71D

FASTA32535,161
        10         20         30         40         50         60 
MNKFKNIAVY GGGSFGTSLA SLAAQNCNNV TLFLRDEAIA KEILHNKTNV KYLGDIKLPA 

        70         80         90        100        110        120 
HLQATTNLDI IKDFELIIIA LPSYAFDDSI KLLKTHSISK DNTLLIATKG FARNPTALLS 

       130        140        150        160        170        180 
DRLKTLLPYN PTAFFVGPNL AKELAKNLPA SASIASLDID IANKIAYNLS SKIFTTNVSS 

       190        200        210        220        230        240 
DIVTLQVAGA LKNIFAIKSG IDLARKQGEN ARATLIVAAL KEIAILSKAL GGMQKNSDIL 

       250        260        270        280        290        300 
LEGVVGDLVL TCYSLGSRNT KFGYELGISS DKKKFLQEYK ELAEGREALK LVLDLIKKYN 

       310        320 
LHMPIISEVA SCVIPYVIPA KAGMT

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006914 Genomic DNA. Translation: AAL03153.1.
PIRG97776.
RefSeqNP_360252.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92I05.
ModBaseSearch...

Protein-protein interaction databases

STRING272944.RC0615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03153; AAL03153; RC0615.
GeneID927704.
KEGGrco:RC0615.
PATRIC17888498. VBIRicCon45613_0700.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246854.
KOK00057.
OMAKHEMEEV.
ProtClustDBPRK00094.

Enzyme and pathway databases

UniPathwayUPA00940.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00394. NAD_Glyc3P_dehydrog.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDA_RICCN
AccessionPrimary (citable) accession number: Q92I05
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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