Q92I02 (TRXB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	RC0618

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Thioredoxin reductase		PRO_0000166742
Regions
	Nucleotide binding	34 – 41	8	FAD By similarity
	Nucleotide binding	281 – 290	10	FAD By similarity
Amino acid modifications
	Disulfide bond	135 ↔ 138		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92I02 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0F1E04D6BC7E111B	FASTA	310	33,469
	10 20 30 40 50 60 MKITTKVLII GSGPAGLSAA IYTARAALKP ILINGMQPGG QLTITTDVEN YPGFAETVQG 70 80 90 100 110 120 PWLMEQMYMQ AKNVGTEIVS DYVEKVDLSK RPFKVFTGAG NEYDAESIII CTGAEAKWLG 130 140 150 160 170 180 IASEQKFRGF GVSACATCDG FFFKNQEIVV VGGGNSAVEE ALYLTNHANK VTIVHRRDSF 190 200 210 220 230 240 RAEKILQDRL FKNSKISVIW DHVVDEIVGS NKPKSVTGVK IQNVHTKEIS LLNCSGVFIA 250 260 270 280 290 300 IGHAPNTGLF TGQIVMDDDN YIITKSGTTR TSVEGVFAAG DVQDKIYRQA VTAAGTGCMA 310 ALEAEKFLNK

References

[1]	"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03156.1.
PIR	B97777.
RefSeq	NP_360255.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92I02.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	927711.
GenomeReviews	Gene locus RC0618 in contig AE006914_GR.
KEGG	rco:RC0618.
PATRIC	17888504. VBIRicCon45613_0703.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VMGAFIA.
ProtClustDB	CLSK870928.
Enzyme and pathway databases
BioCyc	RCON272944:RC0618-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_RICCN

Accession

Primary (citable) accession number: Q92I02

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program