Reviewed, UniProtKB/Swiss-Prot Q92HZ1 (LON_RICCN)

Names and origin

Protein names

Recommended name:
    ATP-dependent protease La
    EC=3.4.21.53

Gene names

Name:	lon
Ordered Locus Names:	RC0629

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	778 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Degrades short-lived regulatory and abnormal proteins in presence of ATP. Hydrolyzes two ATPs for each peptide bond cleaved in the protein substrate By similarity.
Catalytic activity	Hydrolysis of proteins in presence of ATP.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S16 family. Contains 1 Lon domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent peptidase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 778	778	ATP-dependent protease La		PRO_0000280892
Regions
	Domain	5 – 205	201	Lon
	Nucleotide binding	356 – 363	8	ATP Potential
Sites
	Active site	679	1	By similarity
	Active site	722	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92HZ1-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 2039A138A9C8F956	FASTA	778	87,000
	10 20 30 40 50 60 MHKKSLPLMA LRDMVVFPGV IAPIFVGRPK SLQALSHTTI SEEDNSKYIL VTLQKKFDQE 70 80 90 100 110 120 NPSTHELYNT AILAKIIQIV KLPNNTAKIL IEAVARVKLS NIKGEEAFEA NYEIIPDEEI 130 140 150 160 170 180 FDVNNMRSLV DNAVQLFSKY AINDKKVNAE IIETINKEIS NSTNFIDIIN ILASHLITSL 190 200 210 220 230 240 EAKQHLLEET SPFKRITTVI SMLNSNIVNS ETEQALQKRV RKQIEKTQRD YYLHEQMKAI 250 260 270 280 290 300 QKELDEDKSE LADIENKIKS LKLSKEAKEK AEAELKKLRT MNQMSAESGV TRNYLETLLS 310 320 330 340 350 360 LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSSKIRGP ILCLIGPPGV 370 380 390 400 410 420 GKTSLVKSIA EGMGRKYTKL ALGGVRDEAE IRGHRKTYLG SMPGKILGQL KKVKTSNPVM 430 440 450 460 470 480 LLDEIDKMSS DFRGDPASAL LEVLDPEQNS HFVDHYLEVE YDLSNVIFIA TANSHDLPRA 490 500 510 520 530 540 LSDRMEKIYI SGYVEETKLQ IARNYLVPKQ FKMHKIKKDE ITISETAILD LIRYYTKESG 550 560 570 580 590 600 VRALEREIGA LTRKALKQIL ADKSVKHIAI DSNHLEEFLG AKKYNFGLAE KEDQIGSTTG 610 620 630 640 650 660 LAYTEVGGEL LTIEALAFPG KGEIKTTGKL GDVMKESAMA AYSCFRSRAT NFGLKYDNYK 670 680 690 700 710 720 DFDIHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVHRT VAMTGEITLR GNVLPIGGLK 730 740 750 760 770 EKLLAASRGG IKTVLIPEEN VKDLKDIPPN IKESLEIISV SNIDQVLKHA LVGTPINK

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL03167.1. Different initiation.
PIR	E97778.
RefSeq	NP_360266.1.
3D structure databases
HSSP	HSSP built from PDB template 1RR9 based on UniProtKB P08177.
ModBase	Search...
Protein family/group databases
MEROPS	S16.001.
Genome annotation databases
GeneID	927716.
GenomeReviews	Gene locus RC0629 in contig AE006914_GR.
KEGG	rco:RC0629.
NMPDR	fig|272944.1.peg.629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92HZ1.
OMA	Q92HZ1. VMKESIQ.
Enzyme and pathway databases
BioCyc	RCON272944:RC0629-MON.
BRENDA	3.4.21.53. 267518.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR003959. ATPase_AAA_core. IPR008269. Pept_S16_C. IPR004815. Pept_S16_lon. IPR003111. Pept_S16_N. IPR008268. Peptidase_S16_AS. IPR001984. Peptidase_S16_C. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF02190. LON. 1 hit. PF05362. Lon_C. 1 hit. [Graphical view]
PRINTS	PR00830. ENDOLAPTASE.
SMART	SM00382. AAA. 1 hit. SM00464. LON. 1 hit. [Graphical view]
TIGRFAMs	TIGR00763. lon. 1 hit.
PROSITE	PS01046. LON_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LON_RICCN

Accession

Primary (citable) accession number: Q92HZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	June 16, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)