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Q92HV7 (PNP_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyribonucleotide nucleotidyltransferase

EC=2.7.7.8
Alternative name(s):
Polynucleotide phosphorylase
Short name=PNPase
Gene names
Name:pnp
Ordered Locus Names:RC0663
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity. HAMAP-Rule MF_01595

Catalytic activity

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. HAMAP-Rule MF_01595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01595

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01595.

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Contains 1 KH domain.

Contains 1 S1 motif domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 749749Polyribonucleotide nucleotidyltransferase HAMAP-Rule MF_01595
PRO_0000289281

Regions

Domain554 – 61360KH
Domain623 – 69169S1 motif

Sites

Metal binding4871Magnesium By similarity
Metal binding4931Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92HV7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 39D07B0B2ACA13EF

FASTA74982,118
        10         20         30         40         50         60 
MFNEITKSVT WNGQVLELST GKIARQADGA VTVKMGNSVL LCTAVVANKA KEGIGFLPLT 

        70         80         90        100        110        120 
INYREMAYAA GKIPGGFFKH EGKASDREVL VSRLIDRPIR PLFHPAFVNE THVTCSVLSY 

       130        140        150        160        170        180 
DPETPVDILA IIGASAALSL SPAPYLEIVA ASKVGLINGE FVLNPTLALL KTSQLDLVVA 

       190        200        210        220        230        240 
GTSDSVMMVE SEAHLLSEEQ MLEAVKFGFE SFQPVIKIIK ELAEEAKKPK LEMQALYPAS 

       250        260        270        280        290        300 
LKKEIEKLFV KEIEQAFAIK SKQERSTNLD LIPEKVLTHF VSDIENKKYS NYQIESALKA 

       310        320        330        340        350        360 
IESDILRNEI LEKNRRIDGR STTDIRQIAC EIGLLPSAHG SALFTRGETQ SLVSTTFGTS 

       370        380        390        400        410        420 
LDEQIVDSLE GEYKERFMLN YIFPPYSVNE AMPMKAPSRR EVGHGKLAWR AINPILPNKV 

       430        440        450        460        470        480 
QFPYSIRVVA ETTESNGSSS MATVCGSSLA LMYAGVPIKA PVAGIAMGLV KEGKNFAVLS 

       490        500        510        520        530        540 
DILGDEDYFG DMDFKVAGTS EGITALQMDI KISGVDFKIM KVALEQARLG RLHILEQMNK 

       550        560        570        580        590        600 
VISKPNNELS KNAPSTTTIK IDKDKIRDII GPGGKIIKEI CETSGAKIDI SDDGTVSVYA 

       610        620        630        640        650        660 
SDRDKLKVAL DKIKAIVVEP EIGEIFNGTV VKVLDSGAFI NYVGNKDGFV HISEVSGERI 

       670        680        690        700        710        720 
ETVSSVLKQG DIVKVKLIGF DNKGKAKLTI KNADKDKSSN NTKPKTNVNN TNKDNSEPEQ 

       730        740 
RRDSSKKRAW NEDNNAETAE VITERKYFN 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03201.1.
PIRG97782.
RefSeqNP_360300.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92HV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0663.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03201; AAL03201; RC0663.
GeneID927740.
KEGGrco:RC0663.
PATRIC17888614. VBIRicCon45613_0756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1185.
HOGENOMHOG000218326.
KOK00962.
OMALDFFPLT.
OrthoDBEOG6WT8CC.
ProtClustDBPRK11824.

Family and domain databases

Gene3D1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPMF_01595. PNPase.
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERPTHR11252. PTHR11252. 1 hit.
PfamPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFPIRSF005499. PNPase. 1 hit.
SMARTSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsTIGR03591. polynuc_phos. 1 hit.
PROSITEPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNP_RICCN
AccessionPrimary (citable) accession number: Q92HV7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names