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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134L-tryptophanUniRule annotation1
Binding sitei186ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12ATPUniRule annotation3
Nucleotide bindingi18 – 19ATPUniRule annotation2
Nucleotide bindingi146 – 148ATPUniRule annotation3
Nucleotide bindingi195 – 199ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-1182-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:RC0710
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366691 – 330Tryptophan--tRNA ligaseAdd BLAST330

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ92HR1
SMRiQ92HR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 19"HIGH" regionUniRule annotation9
Motifi195 – 199"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q92HR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTVLSGVQ ATGSLHLGNY LGAIKNWVKM QEEYNCFFFL ADLHAITVDI
60 70 80 90 100
KPSELNNSIM EVLAVYLAAG LNPDKVTIFA QSMVKEHTEL AWLLNCVTPL
110 120 130 140 150
GWLKRMTQFK DKAGSDQEKA CLGLFSYPVL MAADILIYKA DIVPVGEDQK
160 170 180 190 200
QHLELTRDIA GVINRKFNKE ILKVPEVLIS ETGTRIMSLR DGLKKMSKSD
210 220 230 240 250
ISDFSRINLK DDNDLIHQKI KKAKTDHLSF VSYDQETRPE ISNLLDIYSS
260 270 280 290 300
LSEESLEQII GNYQNQGFAK FKEDLAEIII TNLQPIRDKY LELMNDKEYL
310 320 330
LKILHKGAEK ARIRASETVN EVKEQFGFVI
Length:330
Mass (Da):37,505
Last modified:December 1, 2001 - v1
Checksum:i20A50C7998F1E11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03248.1
PIRiF97788
RefSeqiWP_010977330.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03248; AAL03248; RC0710
GeneIDi927621
KEGGirco:RC0710
PATRICifig|272944.4.peg.806

Similar proteinsi

Entry informationi

Entry nameiSYW_RICCN
AccessioniPrimary (citable) accession number: Q92HR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health