Q92HP9 (TLCC_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP,ATP carrier protein 3

Alternative name(s):
ADP/ATP translocase 3

Gene names

Name:	tlcC
Synonyms:	tlc3
Ordered Locus Names:	RC0722

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	ADP,ATP carrier protein 3		PRO_0000286472
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Transmembrane	227 – 247	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Transmembrane	387 – 407	21	Helical; Potential
	Transmembrane	446 – 466	21	Helical; Potential
	Transmembrane	470 – 490	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92HP9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2EC589FAD865EA3B	FASTA	501	57,105
	10 20 30 40 50 60 MLPPKIFFEK VKEIMWPIER KELKLFIPMA LMMLCILFNF GALRSIKDSL VVPSMGAEII 70 80 90 100 110 120 SFLKLWLVLP SCVIFTVLYV KLSNNLNFEY IFYIIVGSFL LFFLLFAYII YPNQDIYHPN 130 140 150 160 170 180 DEMINKLIAS YPNFKWFIKI GSQWSYALMY IFAELWSAVV INLMFWQFAN HIFDTSKAKR 190 200 210 220 230 240 FYPVLGMVGN IGLIIAGSVL VFFSSGQDVI DSELLPDSFN SSAGNAIMLQ PIMSIIVTAG 250 260 270 280 290 300 IIAMLLFRII NRFILTDSIN VLDAKKVTAK MKTKLSVIES IKLVIHSKYI GRIALLIICY 310 320 330 340 350 360 GLLINIVEGP WKAKIKELHP NTIDYVNFMG RFNIWMGISC VTFMIIGSNI LRRLGWLISA 370 380 390 400 410 420 LLTPIMLSIT GLMFFIFIIF IEEIGECFGD FNLLYAAIIV GAIQNILSKS SKYSLFDSTK 430 440 450 460 470 480 EMAYIPLSLE LRTKGKAAVE VIGTKFGKSL GAFIQSLIFI IIPTATFDSI IIYLLITFIV 490 500 MMSLWIWNVI KLNKEYVELC K

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03260.1.
PIR	B97790.
RefSeq	NP_360359.1. NC_003103.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0722.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03260; AAL03260; RC0722.
GeneID	928677.
KEGG	rco:RC0722.
PATRIC	17888750. VBIRicCon45613_0822.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3202.
HOGENOM	HOG000238123.
OMA	RLGWLIS.
ProtClustDB	CLSK870724.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00769. AAA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TLCC_RICCN

Accession

Primary (citable) accession number: Q92HP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program