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Q92HP1

- ISCS_RICCN

UniProt

Q92HP1 - ISCS_RICCN

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Protein

Cysteine desulfurase IscS

Gene
iscS, spl1, RC0731
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins By similarity.UniRule annotation

Catalytic activityi

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Cysteine persulfide intermediate By similarity

GO - Molecular functioni

  1. cysteine desulfurase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cysteine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine desulfurase IscS (EC:2.8.1.7)
Gene namesi
Name:iscS
Synonyms:spl1
Ordered Locus Names:RC0731
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Cysteine desulfurase IscSUniRule annotationPRO_0000150275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ92HP1.

Interactioni

Subunit structurei

Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors By similarity.

Protein-protein interaction databases

STRINGi272944.RC0730.

Structurei

3D structure databases

ProteinModelPortaliQ92HP1.
SMRiQ92HP1. Positions 9-398.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1104.
HOGENOMiHOG000017510.
KOiK04487.
OMAiAEKMMQC.
OrthoDBiEOG62RSBK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00331. Cys_desulf_IscS.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR02006. IscS. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92HP1-1 [UniParc]FASTAAdd to Basket

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MNPQLNNLTL PIYMDYQATT PIDPRVMEAM LPYFTTKFGN PHSRSHSFGW    50
EAENAVEEAR SMVAKLIGAD TKEIIFTSGA TESNNLAIKG IAKFYSNKKN 100
HIITVVSEHK CVLDACRHLE QEGIKITYLP IKPNGIIDLE TLKNAITDQT 150
MLVSVMVVNN EIGVVQPLKE IGKICREKGV FFHSDIAQGF GKIPIDVNAF 200
NIDLASISGH KIYGPKGIGA LYVRKKPRVR VTPLINGGGQ ERGMRSGTLP 250
TPLIVGLGMA AEIAYSEMEK DTKHVNYLFD RFLNNIHKRI SEVYLNGDKN 300
QRYKGNLNLS FAGVEGESMI LAIKDLAVSS GSACTSASLE PSYVLRSMGI 350
GEELAHTAIR FGIGRFTTEQ EVDYAVNLIC SKIDKLRELS PLWEMMQEGI 400
DLKKIKWAVH 410
Length:410
Mass (Da):45,475
Last modified:December 1, 2001 - v1
Checksum:i930AB52556C2F9BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03268.1.
PIRiB97791.
RefSeqiNP_360367.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03268; AAL03268; RC0730.
GeneIDi928569.
KEGGirco:RC0730.
PATRICi17888774. VBIRicCon45613_0832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03268.1 .
PIRi B97791.
RefSeqi NP_360367.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92HP1.
SMRi Q92HP1. Positions 9-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0730.

Proteomic databases

PRIDEi Q92HP1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03268 ; AAL03268 ; RC0730 .
GeneIDi 928569.
KEGGi rco:RC0730.
PATRICi 17888774. VBIRicCon45613_0832.

Phylogenomic databases

eggNOGi COG1104.
HOGENOMi HOG000017510.
KOi K04487.
OMAi AEKMMQC.
OrthoDBi EOG62RSBK.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00331. Cys_desulf_IscS.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF005572. NifS. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR02006. IscS. 1 hit.
PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiISCS_RICCN
AccessioniPrimary (citable) accession number: Q92HP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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