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Q92HP1

- ISCS_RICCN

UniProt

Q92HP1 - ISCS_RICCN

Protein

Cysteine desulfurase IscS

Gene

iscS

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.UniRule annotation

    Catalytic activityi

    L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei334 – 3341Cysteine persulfide intermediateUniRule annotation

    GO - Molecular functioni

    1. cysteine desulfurase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cysteine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine desulfurase IscSUniRule annotation (EC:2.8.1.7UniRule annotation)
    Gene namesi
    Name:iscSUniRule annotation
    Synonyms:spl1
    Ordered Locus Names:RC0731
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Cysteine desulfurase IscSPRO_0000150275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei211 – 2111N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ92HP1.

    Interactioni

    Subunit structurei

    Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0730.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92HP1.
    SMRiQ92HP1. Positions 9-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1104.
    HOGENOMiHOG000017510.
    KOiK04487.
    OMAiAEKMMQC.
    OrthoDBiEOG62RSBK.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00331. Cys_desulf_IscS.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR010240. Cys_deSase.
    IPR016454. Cysteine_dSase_NifS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005572. NifS. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR02006. IscS. 1 hit.
    PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92HP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPQLNNLTL PIYMDYQATT PIDPRVMEAM LPYFTTKFGN PHSRSHSFGW    50
    EAENAVEEAR SMVAKLIGAD TKEIIFTSGA TESNNLAIKG IAKFYSNKKN 100
    HIITVVSEHK CVLDACRHLE QEGIKITYLP IKPNGIIDLE TLKNAITDQT 150
    MLVSVMVVNN EIGVVQPLKE IGKICREKGV FFHSDIAQGF GKIPIDVNAF 200
    NIDLASISGH KIYGPKGIGA LYVRKKPRVR VTPLINGGGQ ERGMRSGTLP 250
    TPLIVGLGMA AEIAYSEMEK DTKHVNYLFD RFLNNIHKRI SEVYLNGDKN 300
    QRYKGNLNLS FAGVEGESMI LAIKDLAVSS GSACTSASLE PSYVLRSMGI 350
    GEELAHTAIR FGIGRFTTEQ EVDYAVNLIC SKIDKLRELS PLWEMMQEGI 400
    DLKKIKWAVH 410
    Length:410
    Mass (Da):45,475
    Last modified:December 1, 2001 - v1
    Checksum:i930AB52556C2F9BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03268.1.
    PIRiB97791.
    RefSeqiNP_360367.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03268; AAL03268; RC0730.
    GeneIDi928569.
    KEGGirco:RC0730.
    PATRICi17888774. VBIRicCon45613_0832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03268.1 .
    PIRi B97791.
    RefSeqi NP_360367.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92HP1.
    SMRi Q92HP1. Positions 9-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0730.

    Proteomic databases

    PRIDEi Q92HP1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03268 ; AAL03268 ; RC0730 .
    GeneIDi 928569.
    KEGGi rco:RC0730.
    PATRICi 17888774. VBIRicCon45613_0832.

    Phylogenomic databases

    eggNOGi COG1104.
    HOGENOMi HOG000017510.
    KOi K04487.
    OMAi AEKMMQC.
    OrthoDBi EOG62RSBK.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00331. Cys_desulf_IscS.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR010240. Cys_deSase.
    IPR016454. Cysteine_dSase_NifS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005572. NifS. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR02006. IscS. 1 hit.
    PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiISCS_RICCN
    AccessioniPrimary (citable) accession number: Q92HP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3