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Protein

Transcription termination factor Rho

Gene

rho

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 206ATPUniRule annotation6
Nucleotide bindingi213 – 218ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processTranscription, Transcription regulation, Transcription termination
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:RC0759
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866511 – 458Transcription termination factor RhoAdd BLAST458

Proteomic databases

PRIDEiQ92HL2

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ92HL2
SMRiQ92HL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 153Rho RNA-BDPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076952
KOiK03628
OMAiDYNYLPG
OrthoDBiPOG091H05EO

Family and domain databases

CDDicd04459 Rho_CSD, 1 hit
HAMAPiMF_01884 Rho, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR011112 Rho_N
IPR036269 Rho_N_sf
IPR011113 Rho_RNA-bd
IPR004665 Term_rho
PANTHERiPTHR15184:SF34 PTHR15184:SF34, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF07498 Rho_N, 1 hit
PF07497 Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00357 CSP, 1 hit
SM00959 Rho_N, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
SSF68912 SSF68912, 1 hit
TIGRFAMsiTIGR00767 rho, 1 hit
PROSITEiView protein in PROSITE
PS51856 RHO_RNA_BD, 1 hit

Sequencei

Sequence statusi: Complete.

Q92HL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTNKESTA ELNNTESNNN YNNFAENGNI INLKQLKRKL PEELQAQAEE
60 70 80 90 100
LKIENINSLL KQELVFAILK KSVEQGVLIV GEGVLEVLPD GFGFLRSPEV
110 120 130 140 150
NYLAGPDDIY ISPSQIRRFG LRTGDTVEGQ IRAPKAGERY FALLKVNRVN
160 170 180 190 200
FEDPSKAYHR VHFDNLTPLY PDEKLGLELE NNSKDSKDFS TRVIELVAPM
210 220 230 240 250
GKGQRALIVA PPRTGKTVLL QNIAHAITTN NPEVFLIVLL IDERPEEVTD
260 270 280 290 300
MQRSVRGEVV SSTFDEPASR HVQLAEMVIK KAKRLVEHKK DVVILVDAIT
310 320 330 340 350
RLARAYNTVV PSSGKVLTGG VDANALQRPK RFFGAARNIE NGGSLTIIGT
360 370 380 390 400
ALIETGSRMD EVIFEEFKGT GNSEIVLDRK IADKRIYPAI DITRSGTRKE
410 420 430 440 450
DLLVDKIILN KMWVLRRIID PMGSSEAIEF LLKKLENTKT NGEFFEMMKS

PERPKNGL
Length:458
Mass (Da):51,278
Last modified:December 1, 2001 - v1
Checksum:i6D65C3DA7FD244D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03297.1
PIRiG97794
RefSeqiWP_004998383.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03297; AAL03297; RC0759
GeneIDi927486
KEGGirco:RC0759

Similar proteinsi

Entry informationi

Entry nameiRHO_RICCN
AccessioniPrimary (citable) accession number: Q92HL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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