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Q92HL2

- RHO_RICCN

UniProt

Q92HL2 - RHO_RICCN

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Protein
Transcription termination factor Rho
Gene
rho, RC0759
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2066ATP Reviewed prediction
Nucleotide bindingi213 – 2186ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. RNA-dependent ATPase activity Source: InterPro
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor Rho (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase Rho
Gene namesi
Name:rho
Ordered Locus Names:RC0759
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Transcription termination factor RhoUniRule annotation
PRO_0000286651Add
BLAST

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure By similarity.

Protein-protein interaction databases

STRINGi272944.RC0759.

Structurei

3D structure databases

ProteinModelPortaliQ92HL2.
SMRiQ92HL2. Positions 31-449.

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho family.

Phylogenomic databases

eggNOGiCOG1158.
HOGENOMiHOG000076952.
KOiK03628.
OMAiTEMQRMV.
OrthoDBiEOG6N681W.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92HL2-1 [UniParc]FASTAAdd to Basket

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MNTTNKESTA ELNNTESNNN YNNFAENGNI INLKQLKRKL PEELQAQAEE    50
LKIENINSLL KQELVFAILK KSVEQGVLIV GEGVLEVLPD GFGFLRSPEV 100
NYLAGPDDIY ISPSQIRRFG LRTGDTVEGQ IRAPKAGERY FALLKVNRVN 150
FEDPSKAYHR VHFDNLTPLY PDEKLGLELE NNSKDSKDFS TRVIELVAPM 200
GKGQRALIVA PPRTGKTVLL QNIAHAITTN NPEVFLIVLL IDERPEEVTD 250
MQRSVRGEVV SSTFDEPASR HVQLAEMVIK KAKRLVEHKK DVVILVDAIT 300
RLARAYNTVV PSSGKVLTGG VDANALQRPK RFFGAARNIE NGGSLTIIGT 350
ALIETGSRMD EVIFEEFKGT GNSEIVLDRK IADKRIYPAI DITRSGTRKE 400
DLLVDKIILN KMWVLRRIID PMGSSEAIEF LLKKLENTKT NGEFFEMMKS 450
PERPKNGL 458
Length:458
Mass (Da):51,278
Last modified:December 1, 2001 - v1
Checksum:i6D65C3DA7FD244D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03297.1.
PIRiG97794.
RefSeqiNP_360396.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03297; AAL03297; RC0759.
GeneIDi927486.
KEGGirco:RC0759.
PATRICi17888840. VBIRicCon45613_0863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03297.1 .
PIRi G97794.
RefSeqi NP_360396.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92HL2.
SMRi Q92HL2. Positions 31-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03297 ; AAL03297 ; RC0759 .
GeneIDi 927486.
KEGGi rco:RC0759.
PATRICi 17888840. VBIRicCon45613_0863.

Phylogenomic databases

eggNOGi COG1158.
HOGENOMi HOG000076952.
KOi K03628.
OMAi TEMQRMV.
OrthoDBi EOG6N681W.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01884. Rho.
InterProi IPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsi TIGR00767. rho. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiRHO_RICCN
AccessioniPrimary (citable) accession number: Q92HL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi