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Q92HL2

- RHO_RICCN

UniProt

Q92HL2 - RHO_RICCN

Protein

Transcription termination factor Rho

Gene

rho

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei244 – 2441ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2066ATPUniRule annotation
    Nucleotide bindingi213 – 2186ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. helicase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP
    4. RNA-dependent ATPase activity Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription termination

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
    Alternative name(s):
    ATP-dependent helicase RhoUniRule annotation
    Gene namesi
    Name:rhoUniRule annotation
    Ordered Locus Names:RC0759
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Transcription termination factor RhoPRO_0000286651Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0759.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92HL2.
    SMRiQ92HL2. Positions 31-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Rho family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1158.
    HOGENOMiHOG000076952.
    KOiK03628.
    OMAiTEMQRMV.
    OrthoDBiEOG6N681W.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01884. Rho.
    InterProiIPR003593. AAA+_ATPase.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR011129. Cold_shock_prot.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    IPR011112. Rho_N.
    IPR011113. Rho_RNA-bd.
    IPR004665. Term_rho.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF07498. Rho_N. 1 hit.
    PF07497. Rho_RNA_bind. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00357. CSP. 1 hit.
    SM00959. Rho_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF68912. SSF68912. 1 hit.
    TIGRFAMsiTIGR00767. rho. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92HL2-1 [UniParc]FASTAAdd to Basket

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    MNTTNKESTA ELNNTESNNN YNNFAENGNI INLKQLKRKL PEELQAQAEE    50
    LKIENINSLL KQELVFAILK KSVEQGVLIV GEGVLEVLPD GFGFLRSPEV 100
    NYLAGPDDIY ISPSQIRRFG LRTGDTVEGQ IRAPKAGERY FALLKVNRVN 150
    FEDPSKAYHR VHFDNLTPLY PDEKLGLELE NNSKDSKDFS TRVIELVAPM 200
    GKGQRALIVA PPRTGKTVLL QNIAHAITTN NPEVFLIVLL IDERPEEVTD 250
    MQRSVRGEVV SSTFDEPASR HVQLAEMVIK KAKRLVEHKK DVVILVDAIT 300
    RLARAYNTVV PSSGKVLTGG VDANALQRPK RFFGAARNIE NGGSLTIIGT 350
    ALIETGSRMD EVIFEEFKGT GNSEIVLDRK IADKRIYPAI DITRSGTRKE 400
    DLLVDKIILN KMWVLRRIID PMGSSEAIEF LLKKLENTKT NGEFFEMMKS 450
    PERPKNGL 458
    Length:458
    Mass (Da):51,278
    Last modified:December 1, 2001 - v1
    Checksum:i6D65C3DA7FD244D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03297.1.
    PIRiG97794.
    RefSeqiNP_360396.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03297; AAL03297; RC0759.
    GeneIDi927486.
    KEGGirco:RC0759.
    PATRICi17888840. VBIRicCon45613_0863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03297.1 .
    PIRi G97794.
    RefSeqi NP_360396.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92HL2.
    SMRi Q92HL2. Positions 31-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03297 ; AAL03297 ; RC0759 .
    GeneIDi 927486.
    KEGGi rco:RC0759.
    PATRICi 17888840. VBIRicCon45613_0863.

    Phylogenomic databases

    eggNOGi COG1158.
    HOGENOMi HOG000076952.
    KOi K03628.
    OMAi TEMQRMV.
    OrthoDBi EOG6N681W.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01884. Rho.
    InterProi IPR003593. AAA+_ATPase.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR011129. Cold_shock_prot.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    IPR011112. Rho_N.
    IPR011113. Rho_RNA-bd.
    IPR004665. Term_rho.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF07498. Rho_N. 1 hit.
    PF07497. Rho_RNA_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00357. CSP. 1 hit.
    SM00959. Rho_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF68912. SSF68912. 1 hit.
    TIGRFAMsi TIGR00767. rho. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiRHO_RICCN
    AccessioniPrimary (citable) accession number: Q92HL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3