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Q92HH5 (NUON_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit N
NDH-1 subunit N
Gene names
Name:nuoN
Ordered Locus Names:RC0796
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458NADH-quinone oxidoreductase subunit N HAMAP-Rule MF_00445
PRO_0000117697

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane30 – 5021Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane397 – 41721Helical; Potential
Transmembrane438 – 45821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q92HH5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6D5148BBA80B085F

FASTA45851,062
        10         20         30         40         50         60 
MLLLLPEITL TLIALLGQFF AVMIPNKNRI ISNIIILLCI LSIFLTFKYS SYEGVWYSFA 

        70         80         90        100        110        120 
TGINIGISKS IVLLFTIISM IIYRDYSILV ADELKFEFIT LMLLSVVGIF VAISSRNFLL 

       130        140        150        160        170        180 
LFCGMELTAL TSYALAGFKL NDMKSSEGAL KYFILGSLVS CLSLFGISFI YGFGGSLQFE 

       190        200        210        220        230        240 
DILYKLNDNS GMNLGLIIGI ILFLSSIFFK LSSVPLHFWV PDVYEGSPIT SVTYFNAASK 

       250        260        270        280        290        300 
IGMVIVLLNI SKLIIGNYYP INYNLIKIIA ILSMLFGAFG AIRQTSLKRL MAYSTILNIG 

       310        320        330        340        350        360 
YVLIGVLLHN QEGYKAALLY MLIYAVGSIG FFTCLIILLG KDVDKASFKT IQGIAEYHKT 

       370        380        390        400        410        420 
IAAVISIVMF SMIGIPPLTG FFGKYYLFYQ AINQEEFALA YCGIFTSVVA AFYYLKVVKA 

       430        440        450 
MYFSKKIEII KLPMQYGLLL INYLVVGFLL LGSFIISF 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03334.1.
PIRD97799.
RefSeqNP_360433.1. NC_003103.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03334; AAL03334; RC0796.
GeneID927480.
KEGGrco:RC0796.
PATRIC17888924. VBIRicCon45613_0905.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1007.
HOGENOMHOG000010703.
KOK00343.
OMAPIGEFAA.
OrthoDBEOG64JFNZ.
ProtClustDBPRK05777.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01770. NDH_I_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUON_RICCN
AccessionPrimary (citable) accession number: Q92HH5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names