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Q92HH5

- NUON_RICCN

UniProt

Q92HH5 - NUON_RICCN

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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:RC0796
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458NADH-quinone oxidoreductase subunit NPRO_0000117697Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0796.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalUniRule annotationAdd
BLAST
Transmembranei30 – 5021HelicalUniRule annotationAdd
BLAST
Transmembranei62 – 8221HelicalUniRule annotationAdd
BLAST
Transmembranei94 – 11421HelicalUniRule annotationAdd
BLAST
Transmembranei118 – 13821HelicalUniRule annotationAdd
BLAST
Transmembranei153 – 17321HelicalUniRule annotationAdd
BLAST
Transmembranei194 – 21421HelicalUniRule annotationAdd
BLAST
Transmembranei235 – 25521HelicalUniRule annotationAdd
BLAST
Transmembranei261 – 28121HelicalUniRule annotationAdd
BLAST
Transmembranei290 – 31021HelicalUniRule annotationAdd
BLAST
Transmembranei318 – 33821HelicalUniRule annotationAdd
BLAST
Transmembranei361 – 38121HelicalUniRule annotationAdd
BLAST
Transmembranei397 – 41721HelicalUniRule annotationAdd
BLAST
Transmembranei438 – 45821HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000010703.
KOiK00343.
OMAiIEAQLYG.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92HH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLLPEITL TLIALLGQFF AVMIPNKNRI ISNIIILLCI LSIFLTFKYS
60 70 80 90 100
SYEGVWYSFA TGINIGISKS IVLLFTIISM IIYRDYSILV ADELKFEFIT
110 120 130 140 150
LMLLSVVGIF VAISSRNFLL LFCGMELTAL TSYALAGFKL NDMKSSEGAL
160 170 180 190 200
KYFILGSLVS CLSLFGISFI YGFGGSLQFE DILYKLNDNS GMNLGLIIGI
210 220 230 240 250
ILFLSSIFFK LSSVPLHFWV PDVYEGSPIT SVTYFNAASK IGMVIVLLNI
260 270 280 290 300
SKLIIGNYYP INYNLIKIIA ILSMLFGAFG AIRQTSLKRL MAYSTILNIG
310 320 330 340 350
YVLIGVLLHN QEGYKAALLY MLIYAVGSIG FFTCLIILLG KDVDKASFKT
360 370 380 390 400
IQGIAEYHKT IAAVISIVMF SMIGIPPLTG FFGKYYLFYQ AINQEEFALA
410 420 430 440 450
YCGIFTSVVA AFYYLKVVKA MYFSKKIEII KLPMQYGLLL INYLVVGFLL

LGSFIISF
Length:458
Mass (Da):51,062
Last modified:December 1, 2001 - v1
Checksum:i6D5148BBA80B085F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03334.1.
PIRiD97799.
RefSeqiNP_360433.1. NC_003103.1.
WP_010977408.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03334; AAL03334; RC0796.
GeneIDi927480.
KEGGirco:RC0796.
PATRICi17888924. VBIRicCon45613_0905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03334.1 .
PIRi D97799.
RefSeqi NP_360433.1. NC_003103.1.
WP_010977408.1. NC_003103.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03334 ; AAL03334 ; RC0796 .
GeneIDi 927480.
KEGGi rco:RC0796.
PATRICi 17888924. VBIRicCon45613_0905.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000010703.
KOi K00343.
OMAi IEAQLYG.
OrthoDBi EOG64JFNZ.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiNUON_RICCN
AccessioniPrimary (citable) accession number: Q92HH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3