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Q92HG8

- DNAB_RICCN

UniProt

Q92HG8 - DNAB_RICCN

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Protein

Replicative DNA helicase

Gene

dnaB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi229 – 2368ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA helicase activity Source: InterPro

GO - Biological processi

  1. DNA replication, synthesis of RNA primer Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replicative DNA helicase (EC:3.6.4.12)
Gene namesi
Name:dnaB
Ordered Locus Names:RC0803
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. primosome complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Primosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Replicative DNA helicasePRO_0000102028Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0803.

Structurei

3D structure databases

ProteinModelPortaliQ92HG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 490293SF4 helicasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the helicase family. DnaB subfamily.Curated
Contains 1 SF4 helicase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0305.
HOGENOMiHOG000113195.
KOiK02314.
OMAiPADQIMM.
OrthoDBiEOG6T4RW5.

Family and domain databases

Gene3Di1.10.860.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007692. DNA_helicase_DnaB.
IPR007694. DNA_helicase_DnaB-like_C.
IPR007693. DNA_helicase_DnaB-like_N.
IPR016136. DNA_helicase_N/primase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00772. DnaB. 1 hit.
PF03796. DnaB_C. 1 hit.
[Graphical view]
SUPFAMiSSF48024. SSF48024. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00665. DnaB. 1 hit.
PROSITEiPS51199. SF4_HELICASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92HG8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARNKINNET NILADNEDNL PIPRVLPSNV QAEQMLLGAI LTNNELLNYV
60 70 80 90 100
SEFLRDEHFF EPIHQKIYKA IEKITEKGLT ATPITLRSML TQDELFQEVE
110 120 130 140 150
GAEYLAKLIT MSMMVINPLD YGKIIYDLAI KRNLINIGEE VVNNAYNSSL
160 170 180 190 200
EVEAKEQIEH AEAKLYDLAS EGLNEKSFTK IGISISESLA SINRAMKNND
210 220 230 240 250
HIIGISTGLI DLDNKLCGFH NSDLIILAGR PSMGKTAFAI NLALNACNNM
260 270 280 290 300
RLKNIRDNQE IQSVGFFSLE MSSEQLTTRL LSMCAEIDST SLRTGILGEE
310 320 330 340 350
KYNRLRKEAN TLSELQFFID DTPALSISAI RTRARRMKRK HNLGILFIDY
360 370 380 390 400
LQLIRGVSKS ENRVSEISEI TQGLKAIAKE LNIPVIALSQ LSRAVELRED
410 420 430 440 450
KKPMLSDLRE SGTIEQDADI VMFIYREEYY LTRKEPAAGD AKHAAWLDKL
460 470 480 490
NKVYNIADII VAKHRNGPVG NVPLYYDSQF SKFGNLETRT FNSN
Length:494
Mass (Da):55,756
Last modified:December 1, 2001 - v1
Checksum:iB7B37D3F371FA779
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03341.1.
PIRiC97800.
RefSeqiNP_360440.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03341; AAL03341; RC0803.
GeneIDi927662.
KEGGirco:RC0803.
PATRICi17888938. VBIRicCon45613_0912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03341.1 .
PIRi C97800.
RefSeqi NP_360440.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92HG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03341 ; AAL03341 ; RC0803 .
GeneIDi 927662.
KEGGi rco:RC0803.
PATRICi 17888938. VBIRicCon45613_0912.

Phylogenomic databases

eggNOGi COG0305.
HOGENOMi HOG000113195.
KOi K02314.
OMAi PADQIMM.
OrthoDBi EOG6T4RW5.

Family and domain databases

Gene3Di 1.10.860.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR007692. DNA_helicase_DnaB.
IPR007694. DNA_helicase_DnaB-like_C.
IPR007693. DNA_helicase_DnaB-like_N.
IPR016136. DNA_helicase_N/primase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00772. DnaB. 1 hit.
PF03796. DnaB_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48024. SSF48024. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00665. DnaB. 1 hit.
PROSITEi PS51199. SF4_HELICASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiDNAB_RICCN
AccessioniPrimary (citable) accession number: Q92HG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3