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Q92HG8 (DNAB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Replicative DNA helicase

EC=3.6.4.12
Gene names
Name:dnaB
Ordered Locus Names:RC0803
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the helicase family. DnaB subfamily.

Contains 1 SF4 helicase domain.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentPrimosome
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication, synthesis of RNA primer

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentprimosome complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA helicase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Replicative DNA helicase
PRO_0000102028

Regions

Domain198 – 490293SF4 helicase
Nucleotide binding229 – 2368ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q92HG8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: B7B37D3F371FA779

FASTA49455,756
        10         20         30         40         50         60 
MARNKINNET NILADNEDNL PIPRVLPSNV QAEQMLLGAI LTNNELLNYV SEFLRDEHFF 

        70         80         90        100        110        120 
EPIHQKIYKA IEKITEKGLT ATPITLRSML TQDELFQEVE GAEYLAKLIT MSMMVINPLD 

       130        140        150        160        170        180 
YGKIIYDLAI KRNLINIGEE VVNNAYNSSL EVEAKEQIEH AEAKLYDLAS EGLNEKSFTK 

       190        200        210        220        230        240 
IGISISESLA SINRAMKNND HIIGISTGLI DLDNKLCGFH NSDLIILAGR PSMGKTAFAI 

       250        260        270        280        290        300 
NLALNACNNM RLKNIRDNQE IQSVGFFSLE MSSEQLTTRL LSMCAEIDST SLRTGILGEE 

       310        320        330        340        350        360 
KYNRLRKEAN TLSELQFFID DTPALSISAI RTRARRMKRK HNLGILFIDY LQLIRGVSKS 

       370        380        390        400        410        420 
ENRVSEISEI TQGLKAIAKE LNIPVIALSQ LSRAVELRED KKPMLSDLRE SGTIEQDADI 

       430        440        450        460        470        480 
VMFIYREEYY LTRKEPAAGD AKHAAWLDKL NKVYNIADII VAKHRNGPVG NVPLYYDSQF 

       490 
SKFGNLETRT FNSN 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03341.1.
PIRC97800.
RefSeqNP_360440.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92HG8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03341; AAL03341; RC0803.
GeneID927662.
KEGGrco:RC0803.
PATRIC17888938. VBIRicCon45613_0912.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0305.
HOGENOMHOG000113195.
KOK02314.
OMAYYAKIVE.
OrthoDBEOG6T4RW5.
ProtClustDBPRK09165.

Family and domain databases

Gene3D1.10.860.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR007692. DNA_helicase_DnaB.
IPR007694. DNA_helicase_DnaB-like_C.
IPR007693. DNA_helicase_DnaB-like_N.
IPR016136. DNA_helicase_N/primase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00772. DnaB. 1 hit.
PF03796. DnaB_C. 1 hit.
[Graphical view]
SUPFAMSSF48024. SSF48024. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00665. DnaB. 1 hit.
PROSITEPS51199. SF4_HELICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAB_RICCN
AccessionPrimary (citable) accession number: Q92HG8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names