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Protein

DNA repair protein RadA

Gene

radA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 2518C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi89 – 968ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Stress response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiS16.A04.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RadAUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
Branch migration protein RadAUniRule annotation
Gene namesi
Name:radAUniRule annotation
Ordered Locus Names:RC0810
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444DNA repair protein RadAPRO_0000187935Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92HG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni347 – 44498Lon-protease-likeUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi248 – 2525RadA KNRFG motifUniRule annotation

Domaini

Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.UniRule annotation

Sequence similaritiesi

Belongs to the RecA family. RadA subfamily.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 2518C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000218329.
KOiK04485.
OMAiFEGERGH.
OrthoDBiEOG6DRPHC.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01498. RadA_bact.
InterProiIPR003593. AAA+_ATPase.
IPR004504. DNA_repair_RadA.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PRINTSiPR01874. DNAREPAIRADA.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00416. sms. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92HG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKHYICSN CGNISPKWSG QCFDCGVWGS IVEEIISTNQ VIVKVGSKQD
60 70 80 90 100
FDKLSGHVTE QLRIPTPIGE FNRVLGGGLV LGSAILIGGD PGIGKSTLLL
110 120 130 140 150
QLAASNFASK MNCLYITGEE SLDQIKLRAI RLNLTNYNTD ILAATNLENI
160 170 180 190 200
IASIEANKNN IDLIVIDSIQ TITTKELSSP PGTVSQIRTC ANELVNYAKQ
210 220 230 240 250
NNIIILLSCH VTKDGQLAGP KILEHLVDTV LYFEGDHNNH FRILRSYKNR
260 270 280 290 300
FGGVGEIGVF EMSGSGLIEV TNPSELFLMQ REQNVIGTSI FAGIEGSRPL
310 320 330 340 350
LMEVQALMVP SNMVTPRRSA VGWDANRLSM ILAVLSSRIG LNLANYEVYL
360 370 380 390 400
SIAGGLKIAD PASDLAVTAS LISAATGNPV PEHSVFFGEI SLSGEIRKTA
410 420 430 440
KAETRIKEAV KLGFNKIICS KFENLTYDFI SSVSHLKDLK EIIK
Length:444
Mass (Da):48,227
Last modified:December 1, 2001 - v1
Checksum:iF8BE0DFB5E5C63FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03348.1.
PIRiB97801.
RefSeqiWP_010977421.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03348; AAL03348; RC0810.
GeneIDi927754.
KEGGirco:RC0810.
PATRICi17888954. VBIRicCon45613_0920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03348.1.
PIRiB97801.
RefSeqiWP_010977421.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92HG1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS16.A04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL03348; AAL03348; RC0810.
GeneIDi927754.
KEGGirco:RC0810.
PATRICi17888954. VBIRicCon45613_0920.

Phylogenomic databases

HOGENOMiHOG000218329.
KOiK04485.
OMAiFEGERGH.
OrthoDBiEOG6DRPHC.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01498. RadA_bact.
InterProiIPR003593. AAA+_ATPase.
IPR004504. DNA_repair_RadA.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PRINTSiPR01874. DNAREPAIRADA.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 2 hits.
TIGRFAMsiTIGR00416. sms. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiRADA_RICCN
AccessioniPrimary (citable) accession number: Q92HG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: April 13, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.