Q92HF4 (NUSA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription termination/antitermination protein NusA

Gene names

Name:	nusA
Ordered Locus Names:	RC0817

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in both transcription termination and antitermination By similarity. HAMAP-Rule MF_00945
Subunit structure	Monomer By similarity. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NusA family. Contains 1 KH domain. Contains 1 S1 motif domain.

Ontologies

Keywords
Biological process	Transcription Transcription antitermination Transcription regulation Transcription termination
Cellular component	Cytoplasm
Ligand	RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, termination Inferred from electronic annotation. Source: UniProtKB-KW transcription antitermination Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Transcription termination/antitermination protein NusA HAMAP-Rule MF_00945		PRO_0000181976
Regions
	Domain	139 – 203	65	S1 motif
	Domain	308 – 378	71	KH

Sequences

	Sequence		Length	Mass (Da)
	Q92HF4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 10EE17E5E9A79C5C	FASTA	503	56,523
	10 20 30 40 50 60 MSNIGNVEIL QIIDSVAREK GISKEILIST VEQAVQAAGR KKYGNEYDIK AQINRKTGEI 70 80 90 100 110 120 NLLRILKIVE DVEDYLTQIS LEEALIKNPE AKIGDEIYEY LPPIDHARVS AQAAKQVITQ 130 140 150 160 170 180 RVIEAEREKQ YHDFKDRKGE IINGIVKRIE YGDIIVDLSR AEAIIKKDQL IKGENFKPND 190 200 210 220 230 240 RIKAYVQDVR QETKGPQIFL SRVDNQMLVK LFKLEVPEIL ESIIQIKSVA RDPGSKAKIA 250 260 270 280 290 300 VFAADSSIDP VGSCVGIRGN RVKAVTNELN GEKIDIVLWS NDLAQFIVNA LAPLAPGEIT 310 320 330 340 350 360 KILIDEDRHK VEVVVSQENQ SIAIGRRGQN VRLASQLTGW NIDIMTEEQE SKRRNEEFLT 370 380 390 400 410 420 STALFMEALD VEEVIGQLLS VTGFNSVEQI ASSEISTLTR IEGFEEELAV EIKNRAINYV 430 440 450 460 470 480 DLKNEKIIKK LEDLGVEQEL IDILELSLEL ILQFAEYGIK TIEDLGEMSV NEFKNLAPNS 490 500 NITDENIKLL IKTARQHGAL KDS

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03355.1.
PIR	A97802.
RefSeq	NP_360454.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92HF4.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0817.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03355; AAL03355; RC0817.
GeneID	927779.
KEGG	rco:RC0817.
PATRIC	17888970. VBIRicCon45613_0928.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0195.
HOGENOM	HOG000006394.
KO	K02600.
OMA	IELSRTC.
ProtClustDB	PRK09202.
Family and domain databases
Gene3D	2.40.50.140. 1 hit. 3.30.1480.10. 1 hit. 3.30.300.20. 2 hits.
HAMAP	MF_00945. NusA.
InterPro	IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx. IPR004087. KH_dom. IPR015946. KH_dom-like_a/b. IPR025249. KH_dom_NusA-like. IPR004088. KH_dom_type_1. IPR009019. KH_prok-type. IPR012340. NA-bd_OB-fold. IPR003029. Rbsml_prot_S1_RNA-bd_dom. IPR022967. RNA-binding_domain_S1. IPR013735. TF_NusA_N. IPR010214. Tscrpt_termin_fac_NusA_C_rpt. IPR010213. Tscrpt_termination_fac_NusA. [Graphical view]
Pfam	PF13184. KH_5. 1 hit. PF08529. NusA_N. 1 hit. PF00575. S1. 1 hit. [Graphical view]
SMART	SM00322. KH. 1 hit. SM00316. S1. 1 hit. [Graphical view]
SUPFAM	SSF54814. KH_prok. 2 hits. SSF50249. Nucleic_acid_OB. 1 hit. SSF47794. Rad51_N. 1 hit. SSF69705. TF_NusA_N. 1 hit.
TIGRFAMs	TIGR01953. NusA. 1 hit. TIGR01954. nusA_Cterm_rpt. 1 hit.
PROSITE	PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUSA_RICCN

Accession

Primary (citable) accession number: Q92HF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program