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Q92H06

- SYE2_RICCN

UniProt

Q92H06 - SYE2_RICCN

Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei243 – 2431ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetase 2UniRule annotation
    Short name:
    GluRS 2UniRule annotation
    Gene namesi
    Name:gltX2UniRule annotation
    Ordered Locus Names:RC0966
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Glutamate--tRNA ligase 2PRO_0000119639Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0966.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92H06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini335 – 38349RPE1 insertAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi11 – 2111"HIGH" regionAdd
    BLAST
    Motifi240 – 2445"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation
    Contains 1 RPE1 insert domain.Curated

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252722.
    KOiK01885.
    OMAiHCLRASI.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR005728. Rickett_RPE.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 2 hits.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    TIGR01045. RPE1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92H06-1 [UniParc]FASTAAdd to Basket

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    MNNNVITRFA PSPTGFLHIG SARTALFNYL FARHHNGKFL LRIEDTDKER    50
    STKEAVEAIF SGLKWLGLDW NGEVIFQSKR NNLYKEAALK LLQNGKAYYC 100
    FTRQEEIERQ RQQALENKQH FIFNSEWRDK DPSIYPTDIK PVIRLKTPRE 150
    GSITIHDTLQ GEVVIENSHI DDMVLLRADG TATYMLAVVV DDHDMGITHI 200
    IRGDDHLTNT ARQLAIYQAF GYAVPSMTHI PLIHGADGAK LSKRHGALGI 250
    EAYKDMGYLP ESLCNYLLRL GWSHGDDEII SMTQAIDWFN LDSLGKSPSK 300
    LDFAKMNSLN AHYLRMLDND SLTSKTVEIL EQNYNTLLRH LPYREEFGGN 350
    TERSTAAYID IREDASTGLT YKLPLAVELP KKFKISEQEI GYIKQAMPSL 400
    LVRSETLLEL TRLAQIYLVD SPIIYSQDSK EIIENCDKNL IKQIIENLSE 450
    LEQFDKESVQ NKFKEIAAAN DLKLNDIMKP VRALITGMTA SPSIFEIAEI 500
    LGKENILKRL KII 513
    Length:513
    Mass (Da):58,453
    Last modified:December 1, 2001 - v1
    Checksum:i5465C5274751C5A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03504.1.
    PIRiF97820.
    RefSeqiNP_360603.1. NC_003103.1.
    WP_010977561.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03504; AAL03504; RC0966.
    GeneIDi927885.
    KEGGirco:RC0966.
    PATRICi17889322. VBIRicCon45613_1099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03504.1 .
    PIRi F97820.
    RefSeqi NP_360603.1. NC_003103.1.
    WP_010977561.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92H06.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0966.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03504 ; AAL03504 ; RC0966 .
    GeneIDi 927885.
    KEGGi rco:RC0966.
    PATRICi 17889322. VBIRicCon45613_1099.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252722.
    KOi K01885.
    OMAi HCLRASI.
    OrthoDBi EOG6DRPF7.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR005728. Rickett_RPE.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 2 hits.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    TIGR01045. RPE1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiSYE2_RICCN
    AccessioniPrimary (citable) accession number: Q92H06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3