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Q92GZ0

- RPOA_RICCN

UniProt

Q92GZ0 - RPOA_RICCN

Protein

DNA-directed RNA polymerase subunit alpha

Gene

rpoA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit alphaUniRule annotation (EC:2.7.7.6UniRule annotation)
    Short name:
    RNAP subunit alphaUniRule annotation
    Alternative name(s):
    RNA polymerase subunit alphaUniRule annotation
    Transcriptase subunit alphaUniRule annotation
    Gene namesi
    Name:rpoAUniRule annotation
    Ordered Locus Names:RC0982
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340DNA-directed RNA polymerase subunit alphaPRO_0000175368Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0982.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92GZ0.
    SMRiQ92GZ0. Positions 253-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 236236Alpha N-terminal domain (alpha-NTD)UniRule annotationAdd
    BLAST
    Regioni251 – 34090Alpha C-terminal domain (alpha-CTD)UniRule annotationAdd
    BLAST

    Domaini

    The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.UniRule annotation

    Sequence similaritiesi

    Belongs to the RNA polymerase alpha chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0202.
    HOGENOMiHOG000218481.
    KOiK03040.
    OMAiKAESIHY.
    OrthoDBiEOG68WR84.

    Family and domain databases

    Gene3Di2.170.120.12. 1 hit.
    HAMAPiMF_00059. RNApol_bact_RpoA.
    InterProiIPR011262. DNA-dir_RNA_pol_insert.
    IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
    IPR011773. DNA-dir_RpoA.
    IPR009025. RBP11-like_dimer.
    IPR011260. RNAP_asu_C.
    [Graphical view]
    PfamiPF01000. RNA_pol_A_bac. 1 hit.
    PF03118. RNA_pol_A_CTD. 1 hit.
    PF01193. RNA_pol_L. 1 hit.
    [Graphical view]
    ProDomiPD001179. RNAP_asu_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00662. RPOLD. 1 hit.
    [Graphical view]
    SUPFAMiSSF55257. SSF55257. 2 hits.
    SSF56553. SSF56553. 1 hit.
    TIGRFAMsiTIGR02027. rpoA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92GZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSLSKNWNT LIKPNKVAYE NFPETNNKAK IVVEPLERGF GLTLGNAMRR    50
    VLLSSLQGAA ITSIKIPAIE HEFSSIPGVK EDVSEVILNI KGIEVKMHVA 100
    EKRIMKLKAT GPCVVTAGMI ETGHDVEILN PDHVICDLAK DKQLEMELTC 150
    KVGKGYVLST NSYEDNLPIG EIAIDALFNP VKSVTYKVEN TRVGQVTDYD 200
    KLIMFVETNG DVLPEMAVGL AARILQEQLQ LFISFEEQEE DKQVKTDTLP 250
    FSPYLLKRVD ELELSVRSAN CLKNDNIIYI GDLVKRTESD MLRTPNFGRK 300
    SLNEIKEILA KFNLRFGMDV PDWPPENIQE LSKRYEDSYN 340
    Length:340
    Mass (Da):38,306
    Last modified:December 1, 2001 - v1
    Checksum:i65ABCAF249450DEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03520.1.
    PIRiF97822.
    RefSeqiNP_360619.1. NC_003103.1.
    WP_010977575.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03520; AAL03520; RC0982.
    GeneIDi928124.
    KEGGirco:RC0982.
    PATRICi17889370. VBIRicCon45613_1122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03520.1 .
    PIRi F97822.
    RefSeqi NP_360619.1. NC_003103.1.
    WP_010977575.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92GZ0.
    SMRi Q92GZ0. Positions 253-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03520 ; AAL03520 ; RC0982 .
    GeneIDi 928124.
    KEGGi rco:RC0982.
    PATRICi 17889370. VBIRicCon45613_1122.

    Phylogenomic databases

    eggNOGi COG0202.
    HOGENOMi HOG000218481.
    KOi K03040.
    OMAi KAESIHY.
    OrthoDBi EOG68WR84.

    Family and domain databases

    Gene3Di 2.170.120.12. 1 hit.
    HAMAPi MF_00059. RNApol_bact_RpoA.
    InterProi IPR011262. DNA-dir_RNA_pol_insert.
    IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
    IPR011773. DNA-dir_RpoA.
    IPR009025. RBP11-like_dimer.
    IPR011260. RNAP_asu_C.
    [Graphical view ]
    Pfami PF01000. RNA_pol_A_bac. 1 hit.
    PF03118. RNA_pol_A_CTD. 1 hit.
    PF01193. RNA_pol_L. 1 hit.
    [Graphical view ]
    ProDomi PD001179. RNAP_asu_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00662. RPOLD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55257. SSF55257. 2 hits.
    SSF56553. SSF56553. 1 hit.
    TIGRFAMsi TIGR02027. rpoA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiRPOA_RICCN
    AccessioniPrimary (citable) accession number: Q92GZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3