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Protein

DNA-directed RNA polymerase subunit alpha

Gene

rpoA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-1616-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit alphaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit alphaUniRule annotation
Alternative name(s):
RNA polymerase subunit alphaUniRule annotation
Transcriptase subunit alphaUniRule annotation
Gene namesi
Name:rpoAUniRule annotation
Ordered Locus Names:RC0982
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001753681 – 340DNA-directed RNA polymerase subunit alphaAdd BLAST340

Proteomic databases

PRIDEiQ92GZ0

Interactioni

Subunit structurei

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ92GZ0
SMRiQ92GZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 236Alpha N-terminal domain (alpha-NTD)UniRule annotationAdd BLAST236
Regioni251 – 340Alpha C-terminal domain (alpha-CTD)UniRule annotationAdd BLAST90

Domaini

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.UniRule annotation

Sequence similaritiesi

Belongs to the RNA polymerase alpha chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218481
KOiK03040
OMAiLMKFRNF
OrthoDBiPOG091H001Z

Family and domain databases

Gene3Di2.170.120.12, 1 hit
3.30.1360.10, 2 hits
HAMAPiMF_00059 RNApol_bact_RpoA, 1 hit
InterProiView protein in InterPro
IPR011262 DNA-dir_RNA_pol_insert
IPR011263 DNA-dir_RNA_pol_RpoA/D/Rpb3
IPR011773 DNA-dir_RpoA
IPR036603 RBP11-like
IPR011260 RNAP_asu_C
IPR036643 RNApol_insert_sf
PANTHERiPTHR32108 PTHR32108, 1 hit
PfamiView protein in Pfam
PF01000 RNA_pol_A_bac, 1 hit
PF03118 RNA_pol_A_CTD, 1 hit
PF01193 RNA_pol_L, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001179 RNAP_asu_C, 1 hit
SMARTiView protein in SMART
SM00662 RPOLD, 1 hit
SUPFAMiSSF55257 SSF55257, 2 hits
SSF56553 SSF56553, 1 hit
TIGRFAMsiTIGR02027 rpoA, 1 hit

Sequencei

Sequence statusi: Complete.

Q92GZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLSKNWNT LIKPNKVAYE NFPETNNKAK IVVEPLERGF GLTLGNAMRR
60 70 80 90 100
VLLSSLQGAA ITSIKIPAIE HEFSSIPGVK EDVSEVILNI KGIEVKMHVA
110 120 130 140 150
EKRIMKLKAT GPCVVTAGMI ETGHDVEILN PDHVICDLAK DKQLEMELTC
160 170 180 190 200
KVGKGYVLST NSYEDNLPIG EIAIDALFNP VKSVTYKVEN TRVGQVTDYD
210 220 230 240 250
KLIMFVETNG DVLPEMAVGL AARILQEQLQ LFISFEEQEE DKQVKTDTLP
260 270 280 290 300
FSPYLLKRVD ELELSVRSAN CLKNDNIIYI GDLVKRTESD MLRTPNFGRK
310 320 330 340
SLNEIKEILA KFNLRFGMDV PDWPPENIQE LSKRYEDSYN
Length:340
Mass (Da):38,306
Last modified:December 1, 2001 - v1
Checksum:i65ABCAF249450DEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03520.1
PIRiF97822
RefSeqiWP_010977575.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03520; AAL03520; RC0982
GeneIDi928124
KEGGirco:RC0982
PATRICifig|272944.4.peg.1122

Similar proteinsi

Entry informationi

Entry nameiRPOA_RICCN
AccessioniPrimary (citable) accession number: Q92GZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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