Q92GY7 (KAD_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	RC0985

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP-Rule MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP-Rule MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP-Rule MF_00235
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP-Rule MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	AMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Adenylate kinase HAMAP-Rule MF_00235		PRO_0000158838
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity
	Nucleotide binding	31 – 59	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92GY7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BF785765826527A4	FASTA	212	24,497
	10 20 30 40 50 60 MMVIFLGPPG AGKGTQGKKI AKKIDLPHIA IGDIFRTIIK TSTSEAELIN NYVKQGELIP 70 80 90 100 110 120 NEIVNQVIKN FLLSSEYKNG YILDGYPRNL EQAKFFESFI KEKIKIIYFD VSDELLIKRI 130 140 150 160 170 180 LGRYSCKNCG KIYNRYFVQP KTDNVCDVCG SSTFDYRKDD NEEVIKKRIE VYKTETYPLI 190 200 210 DYYKNSGNFY IVNGSKNEQE IEIDIQKILK IN

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03523.1.
PIR	A97823.
RefSeq	NP_360622.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92GY7.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0985.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03523; AAL03523; RC0985.
GeneID	928128.
KEGG	rco:RC0985.
PATRIC	17889376. VBIRicCon45613_1125.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0563.
HOGENOM	HOG000238772.
KO	K00939.
OMA	QADAMKD.
ProtClustDB	PRK00279.
Enzyme and pathway databases
UniPathway	UPA00588; UER00649.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk.
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. PTHR23359. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
SUPFAM	SSF57774. Adenylate_kinase_Znf_lid. 1 hit.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_RICCN

Accession

Primary (citable) accession number: Q92GY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program