Q92GT5 (UBIE_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquinone/menaquinone biosynthesis methyltransferase ubiE
EC=2.1.1.163
EC=2.1.1.201

Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase

Gene names

Name:	ubiE
Ordered Locus Names:	RC1037

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP-Rule MF_01813
Catalytic activity	A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. HAMAP-Rule MF_01813 S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP-Rule MF_01813
Pathway	Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. HAMAP-Rule MF_01813 Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01813
Sequence similarities	Belongs to the methyltransferase superfamily. UbiE family.

Ontologies

Keywords
Biological process	Menaquinone biosynthesis Ubiquinone biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from electronic annotation. Source: HAMAP menaquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	Ubiquinone/menaquinone biosynthesis methyltransferase ubiE HAMAP-Rule MF_01813		PRO_0000193320

Sequences

	Sequence		Length	Mass (Da)
	Q92GT5 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A88306E7C36DBF3E	FASTA	248	28,260
	10 20 30 40 50 60 MNQTNFGFKK VDYTKKQGLV NNVFSNVADK YDLMNDLMSL GLHRLWKDEF IRQIPNLNSH 70 80 90 100 110 120 ILDVASGSGD IALKLAKKAR DRVNNISLTL SDINEEMLKQ AKKKAIDLNL FQNLKFTVAS 130 140 150 160 170 180 AEELPFPDDS FDYYTIAFGI RNVPDINKAL KEACRVLKPM GKFICLEFSK VKEGYIKDFY 190 200 210 220 230 240 KFYSFNIIPS IGQMIAGNKE AYEYLVESID LFPSQDEFRI MIKDAGFEEV GYKNLSGGIV AIHSAYIQ

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03575.1.
PIR	E97829.
RefSeq	NP_360674.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92GT5.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1037.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03575; AAL03575; RC1037.
GeneID	928183.
KEGG	rco:RC1037.
PATRIC	17889502. VBIRicCon45613_1185.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2226.
HOGENOM	HOG000249463.
KO	K03183.
OMA	PYQYLVE.
ProtClustDB	PRK00216.
Enzyme and pathway databases
UniPathway	UPA00079; UER00169. UPA00232.
Family and domain databases
HAMAP	MF_01813. UbiE_methyltran.
InterPro	IPR004033. UbiE/COQ5_MeTrFase. IPR023576. UbiE/COQ5_MeTrFase_CS. IPR025765. UbiE/COQ5_MeTrFase_dom. [Graphical view]
PANTHER	PTHR10108:SF24. PTHR10108:SF24. 1 hit.
Pfam	PF01209. Ubie_methyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITE	PS01183. UBIE_1. 1 hit. PS01184. UBIE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIE_RICCN

Accession

Primary (citable) accession number: Q92GT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program