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Q92GT5

- UBIE_RICCN

UniProt

Q92GT5 - UBIE_RICCN

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Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene
ubiE, RC1037
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity.UniRule annotation

Catalytic activityi

A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
  2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis, Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.
UPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC:2.1.1.163, EC:2.1.1.201)
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase
Gene namesi
Name:ubiE
Ordered Locus Names:RC1037
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotationPRO_0000193320Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC1037.

Structurei

3D structure databases

ProteinModelPortaliQ92GT5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2226.
HOGENOMiHOG000249463.
KOiK03183.
OMAiIWKRFTI.
OrthoDBiEOG6M6JSB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. UbiE_methyltran.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92GT5-1 [UniParc]FASTAAdd to Basket

« Hide

MNQTNFGFKK VDYTKKQGLV NNVFSNVADK YDLMNDLMSL GLHRLWKDEF    50
IRQIPNLNSH ILDVASGSGD IALKLAKKAR DRVNNISLTL SDINEEMLKQ 100
AKKKAIDLNL FQNLKFTVAS AEELPFPDDS FDYYTIAFGI RNVPDINKAL 150
KEACRVLKPM GKFICLEFSK VKEGYIKDFY KFYSFNIIPS IGQMIAGNKE 200
AYEYLVESID LFPSQDEFRI MIKDAGFEEV GYKNLSGGIV AIHSAYIQ 248
Length:248
Mass (Da):28,260
Last modified:December 1, 2001 - v1
Checksum:iA88306E7C36DBF3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03575.1.
PIRiE97829.
RefSeqiNP_360674.1. NC_003103.1.
WP_010977615.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03575; AAL03575; RC1037.
GeneIDi928183.
KEGGirco:RC1037.
PATRICi17889502. VBIRicCon45613_1185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03575.1 .
PIRi E97829.
RefSeqi NP_360674.1. NC_003103.1.
WP_010977615.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92GT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03575 ; AAL03575 ; RC1037 .
GeneIDi 928183.
KEGGi rco:RC1037.
PATRICi 17889502. VBIRicCon45613_1185.

Phylogenomic databases

eggNOGi COG2226.
HOGENOMi HOG000249463.
KOi K03183.
OMAi IWKRFTI.
OrthoDBi EOG6M6JSB.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00169 .
UPA00232 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01813. UbiE_methyltran.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view ]
Pfami PF01209. Ubie_methyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiUBIE_RICCN
AccessioniPrimary (citable) accession number: Q92GT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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