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Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (ubiE)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processMenaquinone biosynthesis, Ubiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-1695-MONOMER
UniPathwayiUPA00079; UER00169
UPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
Demethylmenaquinone methyltransferaseUniRule annotation
Gene namesi
Name:ubiEUniRule annotation
Ordered Locus Names:RC1037
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001933201 – 248Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEAdd BLAST248

Structurei

3D structure databases

ProteinModelPortaliQ92GT5
SMRiQ92GT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249463
KOiK03183
OMAiVRNFENL
OrthoDBiPOG091H01LK

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92GT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTNFGFKK VDYTKKQGLV NNVFSNVADK YDLMNDLMSL GLHRLWKDEF
60 70 80 90 100
IRQIPNLNSH ILDVASGSGD IALKLAKKAR DRVNNISLTL SDINEEMLKQ
110 120 130 140 150
AKKKAIDLNL FQNLKFTVAS AEELPFPDDS FDYYTIAFGI RNVPDINKAL
160 170 180 190 200
KEACRVLKPM GKFICLEFSK VKEGYIKDFY KFYSFNIIPS IGQMIAGNKE
210 220 230 240
AYEYLVESID LFPSQDEFRI MIKDAGFEEV GYKNLSGGIV AIHSAYIQ
Length:248
Mass (Da):28,260
Last modified:December 1, 2001 - v1
Checksum:iA88306E7C36DBF3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03575.1
PIRiE97829
RefSeqiWP_010977615.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03575; AAL03575; RC1037
GeneIDi928183
KEGGirco:RC1037
PATRICifig|272944.4.peg.1185

Similar proteinsi

Entry informationi

Entry nameiUBIE_RICCN
AccessioniPrimary (citable) accession number: Q92GT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health