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Q92GT5

- UBIE_RICCN

UniProt

Q92GT5 - UBIE_RICCN

Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

    Catalytic activityi

    A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
    S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
    2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis, Ubiquinone biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00079; UER00169.
    UPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
    Alternative name(s):
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
    Demethylmenaquinone methyltransferaseUniRule annotation
    Gene namesi
    Name:ubiEUniRule annotation
    Ordered Locus Names:RC1037
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEPRO_0000193320Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC1037.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92GT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2226.
    HOGENOMiHOG000249463.
    KOiK03183.
    OMAiIWKRFTI.
    OrthoDBiEOG6M6JSB.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01813. UbiE_methyltran.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view]
    PfamiPF01209. Ubie_methyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92GT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQTNFGFKK VDYTKKQGLV NNVFSNVADK YDLMNDLMSL GLHRLWKDEF    50
    IRQIPNLNSH ILDVASGSGD IALKLAKKAR DRVNNISLTL SDINEEMLKQ 100
    AKKKAIDLNL FQNLKFTVAS AEELPFPDDS FDYYTIAFGI RNVPDINKAL 150
    KEACRVLKPM GKFICLEFSK VKEGYIKDFY KFYSFNIIPS IGQMIAGNKE 200
    AYEYLVESID LFPSQDEFRI MIKDAGFEEV GYKNLSGGIV AIHSAYIQ 248
    Length:248
    Mass (Da):28,260
    Last modified:December 1, 2001 - v1
    Checksum:iA88306E7C36DBF3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03575.1.
    PIRiE97829.
    RefSeqiNP_360674.1. NC_003103.1.
    WP_010977615.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03575; AAL03575; RC1037.
    GeneIDi928183.
    KEGGirco:RC1037.
    PATRICi17889502. VBIRicCon45613_1185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03575.1 .
    PIRi E97829.
    RefSeqi NP_360674.1. NC_003103.1.
    WP_010977615.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92GT5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03575 ; AAL03575 ; RC1037 .
    GeneIDi 928183.
    KEGGi rco:RC1037.
    PATRICi 17889502. VBIRicCon45613_1185.

    Phylogenomic databases

    eggNOGi COG2226.
    HOGENOMi HOG000249463.
    KOi K03183.
    OMAi IWKRFTI.
    OrthoDBi EOG6M6JSB.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00169 .
    UPA00232 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01813. UbiE_methyltran.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view ]
    Pfami PF01209. Ubie_methyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiUBIE_RICCN
    AccessioniPrimary (citable) accession number: Q92GT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3