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Q92GQ4

- CLPX_RICCN

UniProt

Q92GQ4 - CLPX_RICCN

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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
BLAST
Nucleotide bindingi117 – 1248ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein folding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:RC1068
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160412Add
BLAST

Proteomic databases

PRIDEiQ92GQ4.

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC1068.

Structurei

3D structure databases

ProteinModelPortaliQ92GQ4.
SMRiQ92GQ4. Positions 8-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1219.
HOGENOMiHOG000010093.
KOiK03544.
OMAiCEDANER.
OrthoDBiEOG625JZK.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00175. ClpX.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92GQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVEADKKAL ICSFCSKKQH EVKKLIAGPA VFICDECIDL CTDIMKEENK
60 70 80 90 100
VALKQITSSI PTPQKICGIL NDYVVGQDQA KKILAVAVYN HYKRLEYVQS
110 120 130 140 150
GNNDVELNKS NILLIGPTGS GKTLLAQTLA KILDVPFTMA DATSLTEAGY
160 170 180 190 200
VGEDVENILL RLLIASEFNI AKAQKGIIYI DEVDKIARKS ENPSITRDVS
210 220 230 240 250
GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI LFICGGAFMG
260 270 280 290 300
IDSIITSRTN HSSIGFAANV NIDKEKNNSE ILKSLEIEDL TKFGLIPEFI
310 320 330 340 350
GRLPIVTTLD ELDKEALITI LTKPKNAIVK QYQKQFELDD AELVIDYSAL
360 370 380 390 400
ETIAEKALAK KTGARGLRSI LEHLLLDSMY KVAELKKQRV TITKEVVNGL
410 420
VEPIMTSLIS TKSNKKQPII TDIPA
Length:425
Mass (Da):46,654
Last modified:December 1, 2001 - v1
Checksum:i69A4E71C49383706
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03606.1.
PIRiD97833.
RefSeqiNP_360705.1. NC_003103.1.
WP_010977646.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03606; AAL03606; RC1068.
GeneIDi928218.
KEGGirco:RC1068.
PATRICi17889580. VBIRicCon45613_1224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03606.1 .
PIRi D97833.
RefSeqi NP_360705.1. NC_003103.1.
WP_010977646.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92GQ4.
SMRi Q92GQ4. Positions 8-48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1068.

Proteomic databases

PRIDEi Q92GQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03606 ; AAL03606 ; RC1068 .
GeneIDi 928218.
KEGGi rco:RC1068.
PATRICi 17889580. VBIRicCon45613_1224.

Phylogenomic databases

eggNOGi COG1219.
HOGENOMi HOG000010093.
KOi K03544.
OMAi CEDANER.
OrthoDBi EOG625JZK.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00175. ClpX.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view ]
Pfami PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00382. clpX. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiCLPX_RICCN
AccessioniPrimary (citable) accession number: Q92GQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3