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Q92GQ4 (CLPX_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:RC1068
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_0000160412

Regions

Zinc finger12 – 3726C4-type HAMAP-Rule MF_00175
Nucleotide binding116 – 1238ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q92GQ4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 69A4E71C49383706

FASTA42546,654
        10         20         30         40         50         60 
MVVEADKKAL ICSFCSKKQH EVKKLIAGPA VFICDECIDL CTDIMKEENK VALKQITSSI 

        70         80         90        100        110        120 
PTPQKICGIL NDYVVGQDQA KKILAVAVYN HYKRLEYVQS GNNDVELNKS NILLIGPTGS 

       130        140        150        160        170        180 
GKTLLAQTLA KILDVPFTMA DATSLTEAGY VGEDVENILL RLLIASEFNI AKAQKGIIYI 

       190        200        210        220        230        240 
DEVDKIARKS ENPSITRDVS GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI 

       250        260        270        280        290        300 
LFICGGAFMG IDSIITSRTN HSSIGFAANV NIDKEKNNSE ILKSLEIEDL TKFGLIPEFI 

       310        320        330        340        350        360 
GRLPIVTTLD ELDKEALITI LTKPKNAIVK QYQKQFELDD AELVIDYSAL ETIAEKALAK 

       370        380        390        400        410        420 
KTGARGLRSI LEHLLLDSMY KVAELKKQRV TITKEVVNGL VEPIMTSLIS TKSNKKQPII 


TDIPA 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03606.1.
PIRD97833.
RefSeqNP_360705.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92GQ4.
SMRQ92GQ4. Positions 8-48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1068.

Proteomic databases

PRIDEQ92GQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03606; AAL03606; RC1068.
GeneID928218.
KEGGrco:RC1068.
PATRIC17889580. VBIRicCon45613_1224.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMALDTMFDL.
OrthoDBEOG625JZK.
ProtClustDBPRK05342.

Family and domain databases

HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_RICCN
AccessionPrimary (citable) accession number: Q92GQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names