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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:RC1111
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Dephospho-CoA kinasePRO_0000172991Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92GL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 191189DPCKUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000010652.
KOiK00859.
OMAiENANFKF.
OrthoDBiPOG091H02KX.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92GL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAIGITGSY ASGKTFMLDY LTEKGYKTFC ADRCIKELYQ DVVLQTQILK
60 70 80 90 100
LLPELESFNI RKISNLIYNN DLAREKLQNF IYPLLIDKLI LFKKENANSK
110 120 130 140 150
FGFAEIPLLY EAKFEKYFDF VVTIYCSEAI RMQRAITRSS FDIEIYNKIK
160 170 180 190
EIQLSQESKI AKADFAINSG VDMLDLEKQI AKLIKDLECR V
Length:191
Mass (Da):22,175
Last modified:December 1, 2001 - v1
Checksum:iA176B97C045B828F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03649.1.
PIRiG97838.
RefSeqiWP_010977684.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03649; AAL03649; RC1111.
GeneIDi928255.
KEGGirco:RC1111.
PATRICi17889694. VBIRicCon45613_1280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03649.1.
PIRiG97838.
RefSeqiWP_010977684.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92GL2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL03649; AAL03649; RC1111.
GeneIDi928255.
KEGGirco:RC1111.
PATRICi17889694. VBIRicCon45613_1280.

Phylogenomic databases

HOGENOMiHOG000010652.
KOiK00859.
OMAiENANFKF.
OrthoDBiPOG091H02KX.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_RICCN
AccessioniPrimary (citable) accession number: Q92GL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.