Q92GI2 (HLYC_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemolysin C homolog

Gene names

Name:	tlyC
Ordered Locus Names:	RC1141

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Miscellaneous	Despite the presence of the tlyC gene, the true SFG rickettsiae are non-hemolytic.
Sequence similarities	Belongs to the UPF0053 family. Hemolysin C subfamily. Contains 2 CBS domains.

Ontologies

Keywords
Domain	CBS domain Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Hemolysin C homolog		PRO_0000319030
Regions
	Domain	80 – 142	63	CBS 1
	Domain	145 – 202	58	CBS 2

Sequences

	Sequence		Length	Mass (Da)
	Q92GI2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 068DA787C61C5FF4	FASTA	299	33,924
	10 20 30 40 50 60 MLKSSKKEDS SKKNQNNKLI FTVRKLFSPI KNFFRKTKTP DNFFGVIKRL KINSQKMTLD 70 80 90 100 110 120 ERNILANLLE LEDKTIEDIM VPRSDIAAIK LTTNLEELSE SIKLEVPHTR TLIYDGTLDN 130 140 150 160 170 180 VVGFIHIKDL FKALATKQNG RLKKLIRKHI IAAPSMKLLD LLAKMRRERT HIAIVVDEYG 190 200 210 220 230 240 GTDGLVTIED LIEEIVGRID DEHDQQLDSD NFKVINNSTI IANARVEVEV LEEIIGEKLH 250 260 270 280 290 NDYDEFDTIG GLVLTRVSSV PAIGTRIDIS ENIEIEVTDA TPRSLKQVKI RLKNGLNGQ

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03679.1.
PIR	E97842.
RefSeq	NP_360778.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92GI2.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1141.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03679; AAL03679; RC1141.
GeneID	928291.
KEGG	rco:RC1141.
PATRIC	17889766. VBIRicCon45613_1315.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1253.
HOGENOM	HOG000062294.
OMA	PVYEENR.
ProtClustDB	CLSK871055.
Family and domain databases
Gene3D	3.30.465.10. 1 hit.
InterPro	IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR000644. Cysta_beta_synth_core. IPR005170. Transptr-assoc_dom. [Graphical view]
Pfam	PF00571. CBS. 1 hit. PF03471. CorC_HlyC. 1 hit. [Graphical view]
SMART	SM00116. CBS. 2 hits. SM01091. CorC_HlyC. 1 hit. [Graphical view]
PROSITE	PS51371. CBS. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HLYC_RICCN

Accession

Primary (citable) accession number: Q92GI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program