Q92GH5 (GLRX2_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable monothiol glutaredoxin-2

Gene names

Name:	grxC2
Synonyms:	grlA
Ordered Locus Names:	RC1148

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the glutaredoxin family. Monothiol subfamily. Contains 1 glutaredoxin domain.
Sequence caution	The sequence AAL03686.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Redox-active center
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Probable monothiol glutaredoxin-2		PRO_0000102264
Regions
	Domain	7 – 107	101	Glutaredoxin
	Region	86 – 87	2	Glutathione binding By similarity
Sites
	Metal binding	32	1	Iron-sulfur (2Fe-2S); shared with dimeric partner By similarity
	Binding site	24	1	Glutathione By similarity
	Binding site	61	1	Glutathione By similarity
	Binding site	73	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92GH5 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 1A1C15F03C29D939	FASTA	107	12,268
	10 20 30 40 50 60 MLENKNFKFI ENEIKNNKVV LFMKGIKKSP ACGFSGTVVA ILNKLGVEFR DINVLFDAEL 70 80 90 100 REDLKKFSDW PTFPQLYING ELVGGCDIAR ELYQSGELEK MLKAYTR

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03686.1. Different initiation.
PIR	D97843.
RefSeq	NP_360785.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92GH5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	928288.
GenomeReviews	Gene locus RC1148 in contig AE006914_GR.
KEGG	rco:RC1148.
PATRIC	17889780. VBIRicCon45613_1322.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NGELEKM.
ProtClustDB	CLSK871057.
Enzyme and pathway databases
BioCyc	RCON272944:RC1148-MONOMER.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR014434. Monothiol_GRX. IPR004480. Monothiol_GRX-rel. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K07390.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF005894. Monothiol_GRX. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00365. TIGR00365. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX2_RICCN

Accession

Primary (citable) accession number: Q92GH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program