Q92GF9 (AK_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartokinase
EC=2.7.2.4

Alternative name(s):
Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	RC1164

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Aspartokinase		PRO_0000288719

Sequences

	Sequence		Length	Mass (Da)
	Q92GF9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 851490610596ED78	FASTA	401	44,583
	10 20 30 40 50 60 MALIIQKFGG TSVANIDRIK KIVPIIKTEI AKNNQVIVVV SAMAGVTNQL VTLCNELSSL 70 80 90 100 110 120 NNISQFAEYD VALSSGEIVT ASLLALALQE EDIKARSFLA WQLPMLTDNN HSKALVESIT 130 140 150 160 170 180 TDLLEKYLQL NTIPIIAGFQ GINKSNRLTT LGRGGSDTTA ALIAAAMKAD RCDIYTDVEG 190 200 210 220 230 240 IFTADPRIIP NAKKIKEIDF LEMLELASSG AQVLHPRAGE LVMRYKIDMR VLSTFSPDTE 250 260 270 280 290 300 GTLITSKDKN MENGIINSIT SNKNLLKISV KSMSLSFLQV ANMITQNNNH IEFMQEIKNN 310 320 330 340 350 360 EEYSFITNLT DKNNLQALLT NLKDDKQIQY FTFDTEIATI SLIGYGIKND CKLLETILSK 370 380 390 400 LTNDNINVHM IQLSEVKITL FINDQDTEKT IFNLYNLFKI S

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03702.1.
PIR	D97845.
RefSeq	NP_360801.1. NC_003103.1.
3D structure databases
HSSP	HSSP built from PDB template 2BNF based on UniProtKB P0A7E9.
ProteinModelPortal	Q92GF9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	928316.
GenomeReviews	Gene locus RC1164 in contig AE006914_GR.
KEGG	rco:RC1164.
NMPDR	fig|272944.1.peg.1164.
PATRIC	17889812. VBIRicCon45613_1338.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NKSNRLT.
ProtClustDB	PRK06635.
Enzyme and pathway databases
BioCyc	RCON272944:RC1164-MONOMER.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00928.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00657. Asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK_RICCN

Accession

Primary (citable) accession number: Q92GF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program