Reviewed, UniProtKB/Swiss-Prot Q92GE0 (FABG_RICCN)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase

Gene names

Name:	fabG
Ordered Locus Names:	RC1183

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-oxoacyl-[acyl-carrier-protein] reductase		PRO_0000286632
Regions
	Nucleotide binding	11 – 35	25	NADP By similarity
Sites
	Active site	148	1	Proton acceptor By similarity
	Binding site	135	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92GE0-1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 03B42A29AEFE1E63	FASTA	241	25,830
	10 20 30 40 50 60 MIDLTGKTSL ITGASGGIGG AIARLLHKLG SHVIISGSNE EKLQSLGKVV KDNYTIEVCN 70 80 90 100 110 120 LADKEECRNL ISKASKLDIL VCNAGITSDT LAIRMKDEDF DKVIDINLKA NFILNREAIK 130 140 150 160 170 180 KMIQNRYGRI INISSIVGIS GNPGQANYCA SKAGLIGMTK SLSYEVATRG ITVNTVAPGF 190 200 210 220 230 240 IKSDMTDKLN EKQREAIVQK IPLGTYGMPE DVAHAVAFLA SDQASYITGQ TIHVNGGMLM V

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03721.1. Different initiation.
PIR	G97847.
RefSeq	NP_360820.1.
3D structure databases
HSSP	HSSP built from PDB template 2FWM based on UniProtKB P15047.
SMR	Q92GE0. Positions 2-239.
ModBase	Search...
Genome annotation databases
GeneID	928334.
GenomeReviews	Gene locus RC1183 in contig AE006914_GR.
KEGG	rco:RC1183.
NMPDR	fig|272944.1.peg.1183.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KELAPRN.
Enzyme and pathway databases
BioCyc	RCON272944:RC1183-MONOMER.
BRENDA	1.1.1.100. 267518.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_RICCN

Accession

Primary (citable) accession number: Q92GE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	February 9, 2010
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)