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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADPBy similarity1
Binding sitei83NADP; via carbonyl oxygenBy similarity1
Binding sitei135SubstrateBy similarity1
Active sitei148Proton acceptorPROSITE-ProRule annotation1
Binding sitei181NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 16NADPBy similarity4
Nucleotide bindingi57 – 58NADPBy similarity2
Nucleotide bindingi148 – 152NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-1898-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:RC1183
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866321 – 2413-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST241

Proteomic databases

PRIDEiQ92GE0

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92GE0
SMRiQ92GE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00059
OMAiGSRNIRC
OrthoDBiPOG091H012M

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q92GE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLTGKTSL ITGASGGIGG AIARLLHKLG SHVIISGSNE EKLQSLGKVV
60 70 80 90 100
KDNYTIEVCN LADKEECRNL ISKASKLDIL VCNAGITSDT LAIRMKDEDF
110 120 130 140 150
DKVIDINLKA NFILNREAIK KMIQNRYGRI INISSIVGIS GNPGQANYCA
160 170 180 190 200
SKAGLIGMTK SLSYEVATRG ITVNTVAPGF IKSDMTDKLN EKQREAIVQK
210 220 230 240
IPLGTYGMPE DVAHAVAFLA SDQASYITGQ TIHVNGGMLM V
Length:241
Mass (Da):25,830
Last modified:May 15, 2007 - v2
Checksum:i03B42A29AEFE1E63
GO

Sequence cautioni

The sequence AAL03721 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03721.1 Different initiation.
PIRiG97847
RefSeqiWP_016830954.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03721; AAL03721; RC1183
GeneIDi928334
KEGGirco:RC1183
PATRICifig|272944.4.peg.1360

Similar proteinsi

Entry informationi

Entry nameiFABG_RICCN
AccessioniPrimary (citable) accession number: Q92GE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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