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Q92GB1 (UDG_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucose 6-dehydrogenase

Short name=UDP-Glc dehydrogenase
Short name=UDP-GlcDH
Short name=UDPGDH
EC=1.1.1.22
Gene names
Name:udg
Ordered Locus Names:RC1212
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processUDP-glucuronate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

polysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432UDP-glucose 6-dehydrogenase
PRO_0000074051

Regions

Nucleotide binding2 – 1918NAD Potential

Sites

Active site2581 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92GB1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: B417A4117831C7ED

FASTA43247,878
        10         20         30         40         50         60 
MNITFIGSGY VGLVSGIIMG YLGHNVTCLD NDEVKISKLN KQILPIYEAK LDEYLKQALE 

        70         80         90        100        110        120 
SDRLKFTNIY NNELQNADAI FITVGTPSKG LGEADLKYVY DAIDKVFEHI NKDCLIVIKS 

       130        140        150        160        170        180 
TVPPGSCSNI IAYLKSRGFS FNVASNPEFL REGSAVEDFL YPDRIVIGVN NKESEAILRK 

       190        200        210        220        230        240 
IYAPLQGVKF VVTDLVTSEL IKYASNSFLA TKIAFINEMA DLCEKIGGNI KDLSKGVGLD 

       250        260        270        280        290        300 
QRIGQNFLNA GPGFGGSCFP KDILALNNLV ENHHIDCRIL KAVIKSNKQR PSNMVDKIAT 

       310        320        330        340        350        360 
LLDGDLKGKN IAILGLTYKA GTDDVRASPA IAIVKILLNK DVYVKAFDPI GLENAKKNLE 

       370        380        390        400        410        420 
HKNLLYLDSA VDACKSVDII VIATEWSEFK ELNWQEIYDL VKSPIIIDFR NILDNETMKK 

       430 
IGFRYYAVGS KI 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03750.1.
PIRD97851.
RefSeqNP_360849.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92GB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03750; AAL03750; RC1212.
GeneID928375.
KEGGrco:RC1212.
PATRIC17889916. VBIRicCon45613_1389.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1004.
HOGENOMHOG000153773.
KOK00012.
OMANEVGNIC.
OrthoDBEOG6ZSP7N.
ProtClustDBCLSK871073.

Enzyme and pathway databases

UniPathwayUPA00038; UER00491.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERPTHR11374. PTHR11374. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUDG_RICCN
AccessionPrimary (citable) accession number: Q92GB1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: December 11, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways