Reviewed, UniProtKB/Swiss-Prot Q92GB1 (UDG_RICCN)

Names and origin

Protein names

Recommended name:
    UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22

Gene names

Name:	udg
Ordered Locus Names:	RC1212

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-glucuronate biosynthesis; UDP-glucuronate from UDP-glucose: step 1/1.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	UDP-glucose 6-dehydrogenase		PRO_0000074051
Regions
	Nucleotide binding	2 – 19	18	NAD Potential
Sites
	Active site	258	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92GB1-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B417A4117831C7ED	FASTA	432	47,878
	10 20 30 40 50 60 MNITFIGSGY VGLVSGIIMG YLGHNVTCLD NDEVKISKLN KQILPIYEAK LDEYLKQALE 70 80 90 100 110 120 SDRLKFTNIY NNELQNADAI FITVGTPSKG LGEADLKYVY DAIDKVFEHI NKDCLIVIKS 130 140 150 160 170 180 TVPPGSCSNI IAYLKSRGFS FNVASNPEFL REGSAVEDFL YPDRIVIGVN NKESEAILRK 190 200 210 220 230 240 IYAPLQGVKF VVTDLVTSEL IKYASNSFLA TKIAFINEMA DLCEKIGGNI KDLSKGVGLD 250 260 270 280 290 300 QRIGQNFLNA GPGFGGSCFP KDILALNNLV ENHHIDCRIL KAVIKSNKQR PSNMVDKIAT 310 320 330 340 350 360 LLDGDLKGKN IAILGLTYKA GTDDVRASPA IAIVKILLNK DVYVKAFDPI GLENAKKNLE 370 380 390 400 410 420 HKNLLYLDSA VDACKSVDII VIATEWSEFK ELNWQEIYDL VKSPIIIDFR NILDNETMKK 430 IGFRYYAVGS KI

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008668 Genomic DNA. Translation: AAL03750.1.
PIR	D97851.
RefSeq	NP_360849.1.
3D structure databases
HSSP	HSSP built from PDB template 1MV8 based on UniProtKB P11759.
ModBase	Search...
Genome annotation databases
GeneID	928375.
GenomeReviews	Gene locus RC1212 in contig AE006914_GR.
KEGG	rco:RC1212.
NMPDR	fig|272944.1.peg.1212.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92GB1.
Enzyme and pathway databases
BioCyc	RCON272944:RC1212-MON.
Family and domain databases
InterPro	IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DHase_C. IPR014026. UDP-Glc/GDP-Man_DHase_dimer. IPR014028. UDP-Glc/GDP-Man_DHase_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DHase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDG_RICCN

Accession

Primary (citable) accession number: Q92GB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	December 1, 2001
Last modified:	November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)