Q92G96 (NUOM_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit M
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit M
NDH-1 subunit M

Gene names

Name:	nuoM
Ordered Locus Names:	RC1227

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD+ + quinol.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the complex I subunit 4 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	NADH-quinone oxidoreductase subunit M		PRO_0000118046
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Transmembrane	216 – 236	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential
	Transmembrane	280 – 300	21	Helical; Potential
	Transmembrane	308 – 328	21	Helical; Potential
	Transmembrane	334 – 354	21	Helical; Potential
	Transmembrane	375 – 395	21	Helical; Potential
	Transmembrane	411 – 431	21	Helical; Potential
	Transmembrane	458 – 478	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92G96 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9686939BCC3BE592	FASTA	493	55,204
	10 20 30 40 50 60 MLELPIISIS IFLPLISVLY ILLFISQSKK ADKPIYVMYV AVLSSVLTFI STIYILIEFD 70 80 90 100 110 120 SSNPAYQFVE RYAWLDKIGL EFHVGVDGIS ILFVVLTSFL TLICIIGSLF TVKKYIKEYL 130 140 150 160 170 180 VCFLLMESFC IGAFTSVNLL LFYLFFEAIL VPMYIIIGVW GGKNRIYAAL KFFLYTFFGS 190 200 210 220 230 240 VFFLLSLIYI YSKMHSFDLT YIFQLTDNIP LFAQQILWWA IFIAFAVKIP IIPFHTWLPD 250 260 270 280 290 300 AHVQAPTSGS VILAGILLKL GGYGFLRVLL PLCPSVSQEF AIYVIYLSVI AIIYASLVAL 310 320 330 340 350 360 AQKDMKKMIA YSSIAHMGYV TIGIFSFTKA GVSGAIFQML SHGVISSCLF LIVGTLYERL 370 380 390 400 410 420 HTKEIAKYGG VASKMPVLAA FFMIAMLGSV GLPGTSGFIG EFLSLLGIYK VNVVATFIAA 430 440 450 460 470 480 LGIIFGAVYM LKLYKEVMLG EITNKEIMHF RDLYKYEIIS IAPLILLIIY FGLMPSSILN 490 VFSLSVENLL VKF

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03765.1.
PIR	C97853.
RefSeq	NP_360864.1. NC_003103.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1227.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03765; AAL03765; RC1227.
GeneID	928376.
KEGG	rco:RC1227.
PATRIC	17889950. VBIRicCon45613_1406.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1008.
HOGENOM	HOG000100683.
KO	K00342.
OMA	PNASQEF.
ProtClustDB	PRK05846.
Family and domain databases
InterPro	IPR010227. NADH_Q_OxRdtase_chainM/4. IPR001750. NADH_UbQ/plastoQ_OxRdtase. IPR003918. NADH_UbQ_OxRdtase. [Graphical view]
Pfam	PF00361. Oxidored_q1. 1 hit. [Graphical view]
PRINTS	PR01437. NUOXDRDTASE4.
TIGRFAMs	TIGR01972. NDH_I_M. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NUOM_RICCN

Accession

Primary (citable) accession number: Q92G96

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program