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Protein

NADH-quinone oxidoreductase subunit M

Gene

nuoM

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + quinone = NAD+ + quinol.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit M (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit M
NDH-1 subunit M
Gene namesi
Name:nuoM
Ordered Locus Names:RC1227
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence AnalysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493NADH-quinone oxidoreductase subunit MPRO_0000118046Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi272944.RC1227.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1008.
HOGENOMiHOG000100683.
KOiK00342.
OMAiEFAIYVI.
OrthoDBiEOG647TZ6.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92G96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELPIISIS IFLPLISVLY ILLFISQSKK ADKPIYVMYV AVLSSVLTFI
60 70 80 90 100
STIYILIEFD SSNPAYQFVE RYAWLDKIGL EFHVGVDGIS ILFVVLTSFL
110 120 130 140 150
TLICIIGSLF TVKKYIKEYL VCFLLMESFC IGAFTSVNLL LFYLFFEAIL
160 170 180 190 200
VPMYIIIGVW GGKNRIYAAL KFFLYTFFGS VFFLLSLIYI YSKMHSFDLT
210 220 230 240 250
YIFQLTDNIP LFAQQILWWA IFIAFAVKIP IIPFHTWLPD AHVQAPTSGS
260 270 280 290 300
VILAGILLKL GGYGFLRVLL PLCPSVSQEF AIYVIYLSVI AIIYASLVAL
310 320 330 340 350
AQKDMKKMIA YSSIAHMGYV TIGIFSFTKA GVSGAIFQML SHGVISSCLF
360 370 380 390 400
LIVGTLYERL HTKEIAKYGG VASKMPVLAA FFMIAMLGSV GLPGTSGFIG
410 420 430 440 450
EFLSLLGIYK VNVVATFIAA LGIIFGAVYM LKLYKEVMLG EITNKEIMHF
460 470 480 490
RDLYKYEIIS IAPLILLIIY FGLMPSSILN VFSLSVENLL VKF
Length:493
Mass (Da):55,204
Last modified:December 1, 2001 - v1
Checksum:i9686939BCC3BE592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03765.1.
PIRiC97853.
RefSeqiNP_360864.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03765; AAL03765; RC1227.
KEGGirco:RC1227.
PATRICi17889950. VBIRicCon45613_1406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03765.1.
PIRiC97853.
RefSeqiNP_360864.1. NC_003103.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272944.RC1227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL03765; AAL03765; RC1227.
KEGGirco:RC1227.
PATRICi17889950. VBIRicCon45613_1406.

Phylogenomic databases

eggNOGiCOG1008.
HOGENOMiHOG000100683.
KOiK00342.
OMAiEFAIYVI.
OrthoDBiEOG647TZ6.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiNUOM_RICCN
AccessioniPrimary (citable) accession number: Q92G96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.