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Q92G96

- NUOM_RICCN

UniProt

Q92G96 - NUOM_RICCN

Protein

NADH-quinone oxidoreductase subunit M

Gene

nuoM

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit M (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit M
    NDH-1 subunit M
    Gene namesi
    Name:nuoM
    Ordered Locus Names:RC1227
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493NADH-quinone oxidoreductase subunit MPRO_0000118046Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC1227.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei334 – 35421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1008.
    HOGENOMiHOG000100683.
    KOiK00342.
    OMAiAVANLGM.
    OrthoDBiEOG647TZ6.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92G96-1 [UniParc]FASTAAdd to Basket

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    MLELPIISIS IFLPLISVLY ILLFISQSKK ADKPIYVMYV AVLSSVLTFI    50
    STIYILIEFD SSNPAYQFVE RYAWLDKIGL EFHVGVDGIS ILFVVLTSFL 100
    TLICIIGSLF TVKKYIKEYL VCFLLMESFC IGAFTSVNLL LFYLFFEAIL 150
    VPMYIIIGVW GGKNRIYAAL KFFLYTFFGS VFFLLSLIYI YSKMHSFDLT 200
    YIFQLTDNIP LFAQQILWWA IFIAFAVKIP IIPFHTWLPD AHVQAPTSGS 250
    VILAGILLKL GGYGFLRVLL PLCPSVSQEF AIYVIYLSVI AIIYASLVAL 300
    AQKDMKKMIA YSSIAHMGYV TIGIFSFTKA GVSGAIFQML SHGVISSCLF 350
    LIVGTLYERL HTKEIAKYGG VASKMPVLAA FFMIAMLGSV GLPGTSGFIG 400
    EFLSLLGIYK VNVVATFIAA LGIIFGAVYM LKLYKEVMLG EITNKEIMHF 450
    RDLYKYEIIS IAPLILLIIY FGLMPSSILN VFSLSVENLL VKF 493
    Length:493
    Mass (Da):55,204
    Last modified:December 1, 2001 - v1
    Checksum:i9686939BCC3BE592
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03765.1.
    PIRiC97853.
    RefSeqiNP_360864.1. NC_003103.1.
    WP_010977792.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03765; AAL03765; RC1227.
    GeneIDi928376.
    KEGGirco:RC1227.
    PATRICi17889950. VBIRicCon45613_1406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03765.1 .
    PIRi C97853.
    RefSeqi NP_360864.1. NC_003103.1.
    WP_010977792.1. NC_003103.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03765 ; AAL03765 ; RC1227 .
    GeneIDi 928376.
    KEGGi rco:RC1227.
    PATRICi 17889950. VBIRicCon45613_1406.

    Phylogenomic databases

    eggNOGi COG1008.
    HOGENOMi HOG000100683.
    KOi K00342.
    OMAi AVANLGM.
    OrthoDBi EOG647TZ6.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiNUOM_RICCN
    AccessioniPrimary (citable) accession number: Q92G96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3