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Q92G96 (NUOM_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit M

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit M
NDH-1 subunit M
Gene names
Name:nuoM
Ordered Locus Names:RC1227
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the complex I subunit 4 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493NADH-quinone oxidoreductase subunit M
PRO_0000118046

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane37 – 5721Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane139 – 15921Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane308 – 32821Helical; Potential
Transmembrane334 – 35421Helical; Potential
Transmembrane375 – 39521Helical; Potential
Transmembrane411 – 43121Helical; Potential
Transmembrane458 – 47821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q92G96 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9686939BCC3BE592

FASTA49355,204
        10         20         30         40         50         60 
MLELPIISIS IFLPLISVLY ILLFISQSKK ADKPIYVMYV AVLSSVLTFI STIYILIEFD 

        70         80         90        100        110        120 
SSNPAYQFVE RYAWLDKIGL EFHVGVDGIS ILFVVLTSFL TLICIIGSLF TVKKYIKEYL 

       130        140        150        160        170        180 
VCFLLMESFC IGAFTSVNLL LFYLFFEAIL VPMYIIIGVW GGKNRIYAAL KFFLYTFFGS 

       190        200        210        220        230        240 
VFFLLSLIYI YSKMHSFDLT YIFQLTDNIP LFAQQILWWA IFIAFAVKIP IIPFHTWLPD 

       250        260        270        280        290        300 
AHVQAPTSGS VILAGILLKL GGYGFLRVLL PLCPSVSQEF AIYVIYLSVI AIIYASLVAL 

       310        320        330        340        350        360 
AQKDMKKMIA YSSIAHMGYV TIGIFSFTKA GVSGAIFQML SHGVISSCLF LIVGTLYERL 

       370        380        390        400        410        420 
HTKEIAKYGG VASKMPVLAA FFMIAMLGSV GLPGTSGFIG EFLSLLGIYK VNVVATFIAA 

       430        440        450        460        470        480 
LGIIFGAVYM LKLYKEVMLG EITNKEIMHF RDLYKYEIIS IAPLILLIIY FGLMPSSILN 

       490 
VFSLSVENLL VKF 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03765.1.
PIRC97853.
RefSeqNP_360864.1. NC_003103.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03765; AAL03765; RC1227.
GeneID928376.
KEGGrco:RC1227.
PATRIC17889950. VBIRicCon45613_1406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1008.
HOGENOMHOG000100683.
KOK00342.
OMAAVANLGM.
OrthoDBEOG647TZ6.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUOM_RICCN
AccessionPrimary (citable) accession number: Q92G96
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names