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Q92G95

- CCMA_RICCN

UniProt

Q92G95 - CCMA_RICCN

Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.UniRule annotation

    Catalytic activityi

    ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. heme-transporting ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cytochrome c-type biogenesis, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
    Alternative name(s):
    Heme exporter protein AUniRule annotation
    Gene namesi
    Name:ccmAUniRule annotation
    Ordered Locus Names:RC1228
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
    2. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191Cytochrome c biogenesis ATP-binding export protein CcmAPRO_0000092206Add
    BLAST

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC1228.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92G95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 190189ABC transporterUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation
    Contains 1 ABC transporter domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4133.
    KOiK02193.
    OMAiVPLWILD.
    OrthoDBiEOG6SNDS1.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR005895. ABC_transptr_haem_export_CcmA.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01189. ccmA. 1 hit.
    PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51243. CCMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92G95-1 [UniParc]FASTAAdd to Basket

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    MLSLHQLQFK NLFDLNITFL PSSITYIKGA NGCGKSSLLR MIAGIMQPSS    50
    GHIYYRNCNI NNIAKLYCTY IGHNLGLKSE MTVFENLKFW SEIYNSAATV 100
    YAAIHYFKLH DLLDKKCYSL SSGMQKIVAI ARLIACQSDL WLLDEVETNL 150
    SKENRALLNN LIVMKANSGG IVLLSSHLES SIKSAQILRI D 191
    Length:191
    Mass (Da):21,427
    Last modified:May 24, 2004 - v2
    Checksum:iD8C69C94FDB9AAB8
    GO

    Sequence cautioni

    The sequence AAL03766.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03766.1. Different initiation.
    PIRiD97853.
    RefSeqiNP_360865.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03766; AAL03766; RC1228.
    GeneIDi928380.
    KEGGirco:RC1228.
    PATRICi17889952. VBIRicCon45613_1407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03766.1 . Different initiation.
    PIRi D97853.
    RefSeqi NP_360865.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92G95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03766 ; AAL03766 ; RC1228 .
    GeneIDi 928380.
    KEGGi rco:RC1228.
    PATRICi 17889952. VBIRicCon45613_1407.

    Phylogenomic databases

    eggNOGi COG4133.
    KOi K02193.
    OMAi VPLWILD.
    OrthoDBi EOG6SNDS1.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR005895. ABC_transptr_haem_export_CcmA.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01189. ccmA. 1 hit.
    PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51243. CCMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiCCMA_RICCN
    AccessioniPrimary (citable) accession number: Q92G95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3