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Q92G95 (CCMA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA

EC=3.6.3.41
Alternative name(s):
Heme exporter protein A
Gene names
Name:ccmA
Ordered Locus Names:RC1228
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.

Catalytic activity

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Subunit structure

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]

Contains 1 ABC transporter domain.

Sequence caution

The sequence AAL03766.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Cytochrome c biogenesis ATP-binding export protein CcmA
PRO_0000092206

Regions

Domain2 – 190189ABC transporter
Nucleotide binding29 – 368ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q92G95 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: D8C69C94FDB9AAB8

FASTA19121,427
        10         20         30         40         50         60 
MLSLHQLQFK NLFDLNITFL PSSITYIKGA NGCGKSSLLR MIAGIMQPSS GHIYYRNCNI 

        70         80         90        100        110        120 
NNIAKLYCTY IGHNLGLKSE MTVFENLKFW SEIYNSAATV YAAIHYFKLH DLLDKKCYSL 

       130        140        150        160        170        180 
SSGMQKIVAI ARLIACQSDL WLLDEVETNL SKENRALLNN LIVMKANSGG IVLLSSHLES 

       190 
SIKSAQILRI D 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03766.1. Different initiation.
PIRD97853.
RefSeqNP_360865.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92G95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1228.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03766; AAL03766; RC1228.
GeneID928380.
KEGGrco:RC1228.
PATRIC17889952. VBIRicCon45613_1407.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4133.
KOK02193.
OMAVPLWILD.
OrthoDBEOG6SNDS1.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01189. ccmA. 1 hit.
PROSITEPS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCMA_RICCN
AccessionPrimary (citable) accession number: Q92G95
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names