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Q92G95

- CCMA_RICCN

UniProt

Q92G95 - CCMA_RICCN

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Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 368ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. heme-transporting ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
Alternative name(s):
Heme exporter protein AUniRule annotation
Gene namesi
Name:ccmAUniRule annotation
Ordered Locus Names:RC1228
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
  2. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Cytochrome c biogenesis ATP-binding export protein CcmAPRO_0000092206Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC1228.

Structurei

3D structure databases

ProteinModelPortaliQ92G95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 190189ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG4133.
KOiK02193.
OMAiVPLWILD.
OrthoDBiEOG6SNDS1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01189. ccmA. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92G95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSLHQLQFK NLFDLNITFL PSSITYIKGA NGCGKSSLLR MIAGIMQPSS
60 70 80 90 100
GHIYYRNCNI NNIAKLYCTY IGHNLGLKSE MTVFENLKFW SEIYNSAATV
110 120 130 140 150
YAAIHYFKLH DLLDKKCYSL SSGMQKIVAI ARLIACQSDL WLLDEVETNL
160 170 180 190
SKENRALLNN LIVMKANSGG IVLLSSHLES SIKSAQILRI D
Length:191
Mass (Da):21,427
Last modified:May 24, 2004 - v2
Checksum:iD8C69C94FDB9AAB8
GO

Sequence cautioni

The sequence AAL03766.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03766.1. Different initiation.
PIRiD97853.
RefSeqiNP_360865.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03766; AAL03766; RC1228.
GeneIDi928380.
KEGGirco:RC1228.
PATRICi17889952. VBIRicCon45613_1407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03766.1 . Different initiation.
PIRi D97853.
RefSeqi NP_360865.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92G95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03766 ; AAL03766 ; RC1228 .
GeneIDi 928380.
KEGGi rco:RC1228.
PATRICi 17889952. VBIRicCon45613_1407.

Phylogenomic databases

eggNOGi COG4133.
KOi K02193.
OMAi VPLWILD.
OrthoDBi EOG6SNDS1.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01189. ccmA. 1 hit.
PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiCCMA_RICCN
AccessioniPrimary (citable) accession number: Q92G95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 1, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3