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Q92G93

- NUOH_RICCN

UniProt

Q92G93 - NUOH_RICCN

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Protein

NADH-quinone oxidoreductase subunit H

Gene
nuoH, RC1230
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit H (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit H
NDH-1 subunit H
Gene namesi
Name:nuoH
Ordered Locus Names:RC1230
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed predictionAdd
BLAST
Transmembranei50 – 7021Helical; Reviewed predictionAdd
BLAST
Transmembranei82 – 10221Helical; Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Reviewed predictionAdd
BLAST
Transmembranei161 – 18121Helical; Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Reviewed predictionAdd
BLAST
Transmembranei311 – 33121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339NADH-quinone oxidoreductase subunit HUniRule annotationPRO_0000117532Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi272944.RC1230.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1005.
HOGENOMiHOG000228276.
KOiK00337.
OMAiWGLLQSF.
OrthoDBiEOG6B62B4.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92G93-1 [UniParc]FASTAAdd to Basket

« Hide

MLELFFEYIF PLIIIALKVV AITIPLILCV AYLTYAERRV IGLMQLRRGP    50
NVVGPFGLLQ PIADAVKLLF KEPIIPTNSD KILFILAPMI TFILSLIGWA 100
VIPFAKGVVL ADINVGVLYI LAISSLSVYG IIIAGWASNS KYAFLGAIRS 150
SAQMISYEMS MGLVIITVLL TNGTLNLSGI IEAQRTMPWW IDLMLLPMGV 200
VFFISVLAET NRLPFDLPEA ESELVAGYNV EYSSMGFALF FLGEYANMIL 250
VSAMTTTFFL GGYLPPFNIS WLDCIPGFFW FVFKVGFLLF CFLWIRATLP 300
RYRYDQLMRL GWKVFLPLTL FWVVLVSSVL VYTDNLPSI 339
Length:339
Mass (Da):38,061
Last modified:December 1, 2001 - v1
Checksum:iDD72D3118D589095
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03768.1.
PIRiF97853.
RefSeqiNP_360867.1. NC_003103.1.
WP_010977795.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03768; AAL03768; RC1230.
GeneIDi928384.
KEGGirco:RC1230.
PATRICi17889958. VBIRicCon45613_1410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03768.1 .
PIRi F97853.
RefSeqi NP_360867.1. NC_003103.1.
WP_010977795.1. NC_003103.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03768 ; AAL03768 ; RC1230 .
GeneIDi 928384.
KEGGi rco:RC1230.
PATRICi 17889958. VBIRicCon45613_1410.

Phylogenomic databases

eggNOGi COG1005.
HOGENOMi HOG000228276.
KOi K00337.
OMAi WGLLQSF.
OrthoDBi EOG6B62B4.

Family and domain databases

HAMAPi MF_01350. NDH1_NuoH.
InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view ]
PANTHERi PTHR11432. PTHR11432. 1 hit.
Pfami PF00146. NADHdh. 1 hit.
[Graphical view ]
PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiNUOH_RICCN
AccessioniPrimary (citable) accession number: Q92G93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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