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Q92G93 (NUOH_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit H

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit H
NDH-1 subunit H
Gene names
Name:nuoH
Ordered Locus Names:RC1230
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity. HAMAP-Rule MF_01350

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01350

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01350.

Sequence similarities

Belongs to the complex I subunit 1 family.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339NADH-quinone oxidoreductase subunit H HAMAP-Rule MF_01350
PRO_0000117532

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane275 – 29521Helical; Potential
Transmembrane311 – 33121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q92G93 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DD72D3118D589095

FASTA33938,061
        10         20         30         40         50         60 
MLELFFEYIF PLIIIALKVV AITIPLILCV AYLTYAERRV IGLMQLRRGP NVVGPFGLLQ 

        70         80         90        100        110        120 
PIADAVKLLF KEPIIPTNSD KILFILAPMI TFILSLIGWA VIPFAKGVVL ADINVGVLYI 

       130        140        150        160        170        180 
LAISSLSVYG IIIAGWASNS KYAFLGAIRS SAQMISYEMS MGLVIITVLL TNGTLNLSGI 

       190        200        210        220        230        240 
IEAQRTMPWW IDLMLLPMGV VFFISVLAET NRLPFDLPEA ESELVAGYNV EYSSMGFALF 

       250        260        270        280        290        300 
FLGEYANMIL VSAMTTTFFL GGYLPPFNIS WLDCIPGFFW FVFKVGFLLF CFLWIRATLP 

       310        320        330 
RYRYDQLMRL GWKVFLPLTL FWVVLVSSVL VYTDNLPSI 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03768.1.
PIRF97853.
RefSeqNP_360867.1. NC_003103.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1230.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03768; AAL03768; RC1230.
GeneID928384.
KEGGrco:RC1230.
PATRIC17889958. VBIRicCon45613_1410.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1005.
HOGENOMHOG000228276.
KOK00337.
OMAWGLLQSF.
OrthoDBEOG6B62B4.

Family and domain databases

HAMAPMF_01350. NDH1_NuoH.
InterProIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERPTHR11432. PTHR11432. 1 hit.
PfamPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOH_RICCN
AccessionPrimary (citable) accession number: Q92G93
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names