Q92G93 (NUOH_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-quinone oxidoreductase subunit H
EC=1.6.99.5

Alternative name(s):
NADH dehydrogenase I subunit H
NDH-1 subunit H

Gene names

Name:	nuoH
Ordered Locus Names:	RC1230

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity. HAMAP-Rule MF_01350
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01350
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NADH dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	NADH-quinone oxidoreductase subunit H HAMAP-Rule MF_01350		PRO_0000117532
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	50 – 70	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	161 – 181	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential
	Transmembrane	275 – 295	21	Helical; Potential
	Transmembrane	311 – 331	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92G93 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DD72D3118D589095	FASTA	339	38,061
	10 20 30 40 50 60 MLELFFEYIF PLIIIALKVV AITIPLILCV AYLTYAERRV IGLMQLRRGP NVVGPFGLLQ 70 80 90 100 110 120 PIADAVKLLF KEPIIPTNSD KILFILAPMI TFILSLIGWA VIPFAKGVVL ADINVGVLYI 130 140 150 160 170 180 LAISSLSVYG IIIAGWASNS KYAFLGAIRS SAQMISYEMS MGLVIITVLL TNGTLNLSGI 190 200 210 220 230 240 IEAQRTMPWW IDLMLLPMGV VFFISVLAET NRLPFDLPEA ESELVAGYNV EYSSMGFALF 250 260 270 280 290 300 FLGEYANMIL VSAMTTTFFL GGYLPPFNIS WLDCIPGFFW FVFKVGFLLF CFLWIRATLP 310 320 330 RYRYDQLMRL GWKVFLPLTL FWVVLVSSVL VYTDNLPSI

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03768.1.
PIR	F97853.
RefSeq	NP_360867.1. NC_003103.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1230.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03768; AAL03768; RC1230.
GeneID	928384.
KEGG	rco:RC1230.
PATRIC	17889958. VBIRicCon45613_1410.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1005.
HOGENOM	HOG000228276.
KO	K00337.
OMA	PMFIIFF.
ProtClustDB	PRK06076.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH.
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. PTHR11432. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOH_RICCN

Accession

Primary (citable) accession number: Q92G93

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program