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Q92G92

- NUOG_RICCN

UniProt

Q92G92 - NUOG_RICCN

Protein

NADH-quinone oxidoreductase subunit G

Gene

nuoG

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.By similarity

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.

    Cofactori

    Binds 1 2Fe-2S cluster per subunit.By similarity
    Binds 2 4Fe-4S clusters per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi34 – 341Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi45 – 451Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi62 – 621Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi94 – 941Iron-sulfur 2 (4Fe-4S); via pros nitrogenBy similarity
    Metal bindingi98 – 981Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi107 – 1071Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi146 – 1461Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi149 – 1491Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi152 – 1521Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 3 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. metal ion binding Source: UniProtKB-KW
    5. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    6. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit G (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit G
    NDH-1 subunit G
    Gene namesi
    Name:nuoG
    Ordered Locus Names:RC1231
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 671671NADH-quinone oxidoreductase subunit GPRO_0000118561Add
    BLAST

    Keywords - PTMi

    Quinone

    Proteomic databases

    PRIDEiQ92G92.

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC1231.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92G92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 78782Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 271574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complex I 75 kDa subunit family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1034.
    HOGENOMiHOG000031442.
    KOiK00336.
    OMAiFQGNDVA.
    OrthoDBiEOG6CVV7G.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
    IPR010228. NADH_UbQ_OxRdtase_Gsu.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    IPR015405. NuoG_C.
    [Graphical view]
    PfamiPF09326. DUF1982. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01973. NuoG. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00641. COMPLEX1_75K_1. 1 hit.
    PS00642. COMPLEX1_75K_2. 1 hit.
    PS00643. COMPLEX1_75K_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92G92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKLNVDGSE IEVSEGSTVY QACTQAGKEI PHFCYHQRLK IAGNCRMCLV    50
    EMEKSPKPIA SCAMPVSNGM VIHTDTPMVK KAREGVMEFL LINHPLDCPI 100
    CDQGGECNLQ DQAFRYGKGT NRFHENKRSI KDKYMGPLIK TAMTRCIQCT 150
    RCIRFASDIA GIEEIGAIHR GEHIEVTSYL EQTLDSEISG NMIDICPVGA 200
    LNSKPYAFKA RKWELKHTAS IGVHDAEGSN IRIDSRGDEV MRILPRVNEE 250
    INEEWLSDKN RFSYDGLKYQ RLDRPYIRKN GKLVEASWSE ALKTVADKIK 300
    SVKPEKIVAI AGSLSSVEAM FMLKTLLQKL GSNNYSVNQF DYKLDTMQRG 350
    NYLFNTTIAG IEKADLCLLI GANPRQIAPV LNSRIGMRVR ADSLKVARIG 400
    GGHNQTYKIQ DLGSDIKIIE ELAIGTHEFT KALKAAKYLM IIVGDGVYAR 450
    DDGYAILSLI HKIVTEYNIM RDDWKGFNIL HNHASIVGGL DIGFNTPIKL 500
    EELELAYLLG TDAIPFDKLK STFIIYQGHH GDAGASSADV ILPAAAYTEQ 550
    SGIYVNLEGR PQIAEKAVSP VGVAKEDIEI IKELAGYLKI DIGMDNLQEV 600
    RVRLAKEYKV FASIDRIIEN KFSKFSSKDK LSKEPITAEP INYYMTDVIS 650
    KNSVTMAKCV EAKEARDEEV A 671
    Length:671
    Mass (Da):74,809
    Last modified:May 15, 2007 - v2
    Checksum:i9D9BB900EE9AE68D
    GO

    Sequence cautioni

    The sequence AAL03769.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03769.1. Different initiation.
    PIRiG97853.
    RefSeqiNP_360868.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03769; AAL03769; RC1231.
    GeneIDi928385.
    KEGGirco:RC1231.
    PATRICi17889960. VBIRicCon45613_1411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03769.1 . Different initiation.
    PIRi G97853.
    RefSeqi NP_360868.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92G92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1231.

    Proteomic databases

    PRIDEi Q92G92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03769 ; AAL03769 ; RC1231 .
    GeneIDi 928385.
    KEGGi rco:RC1231.
    PATRICi 17889960. VBIRicCon45613_1411.

    Phylogenomic databases

    eggNOGi COG1034.
    HOGENOMi HOG000031442.
    KOi K00336.
    OMAi FQGNDVA.
    OrthoDBi EOG6CVV7G.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
    IPR010228. NADH_UbQ_OxRdtase_Gsu.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    IPR015405. NuoG_C.
    [Graphical view ]
    Pfami PF09326. DUF1982. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SMARTi SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01973. NuoG. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00641. COMPLEX1_75K_1. 1 hit.
    PS00642. COMPLEX1_75K_2. 1 hit.
    PS00643. COMPLEX1_75K_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiNUOG_RICCN
    AccessioniPrimary (citable) accession number: Q92G92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3