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Q92G92 (NUOG_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit G

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene names
Name:nuoG
Ordered Locus Names:RC1231
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Binds 2 4Fe-4S clusters per subunit By similarity.

Sequence similarities

Belongs to the complex I 75 kDa subunit family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S Mo/W bis-MGD-type domain.

Sequence caution

The sequence AAL03769.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 671671NADH-quinone oxidoreductase subunit G
PRO_0000118561

Regions

Domain1 – 78782Fe-2S ferredoxin-type
Domain215 – 271574Fe-4S Mo/W bis-MGD-type

Sites

Metal binding341Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding451Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding621Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding941Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity
Metal binding981Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1011Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1071Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1461Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1491Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1521Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 3 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92G92 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 9D9BB900EE9AE68D

FASTA67174,809
        10         20         30         40         50         60 
MIKLNVDGSE IEVSEGSTVY QACTQAGKEI PHFCYHQRLK IAGNCRMCLV EMEKSPKPIA 

        70         80         90        100        110        120 
SCAMPVSNGM VIHTDTPMVK KAREGVMEFL LINHPLDCPI CDQGGECNLQ DQAFRYGKGT 

       130        140        150        160        170        180 
NRFHENKRSI KDKYMGPLIK TAMTRCIQCT RCIRFASDIA GIEEIGAIHR GEHIEVTSYL 

       190        200        210        220        230        240 
EQTLDSEISG NMIDICPVGA LNSKPYAFKA RKWELKHTAS IGVHDAEGSN IRIDSRGDEV 

       250        260        270        280        290        300 
MRILPRVNEE INEEWLSDKN RFSYDGLKYQ RLDRPYIRKN GKLVEASWSE ALKTVADKIK 

       310        320        330        340        350        360 
SVKPEKIVAI AGSLSSVEAM FMLKTLLQKL GSNNYSVNQF DYKLDTMQRG NYLFNTTIAG 

       370        380        390        400        410        420 
IEKADLCLLI GANPRQIAPV LNSRIGMRVR ADSLKVARIG GGHNQTYKIQ DLGSDIKIIE 

       430        440        450        460        470        480 
ELAIGTHEFT KALKAAKYLM IIVGDGVYAR DDGYAILSLI HKIVTEYNIM RDDWKGFNIL 

       490        500        510        520        530        540 
HNHASIVGGL DIGFNTPIKL EELELAYLLG TDAIPFDKLK STFIIYQGHH GDAGASSADV 

       550        560        570        580        590        600 
ILPAAAYTEQ SGIYVNLEGR PQIAEKAVSP VGVAKEDIEI IKELAGYLKI DIGMDNLQEV 

       610        620        630        640        650        660 
RVRLAKEYKV FASIDRIIEN KFSKFSSKDK LSKEPITAEP INYYMTDVIS KNSVTMAKCV 

       670 
EAKEARDEEV A 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03769.1. Different initiation.
PIRG97853.
RefSeqNP_360868.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92G92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1231.

Proteomic databases

PRIDEQ92G92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03769; AAL03769; RC1231.
GeneID928385.
KEGGrco:RC1231.
PATRIC17889960. VBIRicCon45613_1411.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1034.
HOGENOMHOG000031442.
KOK00336.
OMASSRYQEN.
OrthoDBEOG6CVV7G.
ProtClustDBPRK09130.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view]
PfamPF09326. DUF1982. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SMARTSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMSSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR01973. NuoG. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOG_RICCN
AccessionPrimary (citable) accession number: Q92G92
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 15, 2007
Last modified: February 19, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names