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Q92G53

- PLD_RICCN

UniProt

Q92G53 - PLD_RICCN

Protein

Phospholipase D

Gene

pld

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Could be a virulence factor.1 Publication

    Catalytic activityi

    A phosphatidylcholine + H2O = choline + a phosphatidate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei147 – 1471PROSITE-ProRule annotation
    Active sitei149 – 1491PROSITE-ProRule annotation
    Active sitei154 – 1541PROSITE-ProRule annotation

    GO - Molecular functioni

    1. N-acylphosphatidylethanolamine-specific phospholipase D activity Source: UniProtKB-EC
    2. phospholipase D activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase D (EC:3.1.4.4)
    Short name:
    PLD
    Alternative name(s):
    Choline phosphatase
    Gene namesi
    Name:pld
    Ordered Locus Names:RC1270
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 200175Phospholipase DPRO_0000274781Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi272944.RC1270.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92G53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini142 – 16928PLD phosphodiesterasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phospholipase D family.Curated
    Contains 1 PLD phosphodiesterase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1502.
    HOGENOMiHOG000222239.
    KOiK17717.
    OMAiANNDKYT.
    OrthoDBiEOG6PW23S.

    Family and domain databases

    InterProiIPR025202. PLD-like_dom.
    IPR001736. PLipase_D/transphosphatidylase.
    [Graphical view]
    PfamiPF13091. PLDc_2. 1 hit.
    [Graphical view]
    SMARTiSM00155. PLDc. 1 hit.
    [Graphical view]
    PROSITEiPS50035. PLD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92G53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRKNNKFIE ISIAFILGIA LGLYGQNPDY FTNLISQKSL ALSALQIKHY    50
    NISELSRSKV STCFTPPAGC TKFIANQIDK AEESIYMQAY GMSDALITTA 100
    LINAQARGVK VRILLDRSNL KQKFSKLHEL QRAKIDVDID KVPGIAHNKV 150
    IIIDKKKVIT GSFNFTAAAD KRNAENVIII EDQELAESYL QNWLNRKASN 200
    Length:200
    Mass (Da):22,418
    Last modified:December 1, 2001 - v1
    Checksum:iF878E8D78AF6E6F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03808.1.
    PIRiF97858.
    RefSeqiNP_360907.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03808; AAL03808; RC1270.
    GeneIDi928420.
    KEGGirco:RC1270.
    PATRICi17890054. VBIRicCon45613_1457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03808.1 .
    PIRi F97858.
    RefSeqi NP_360907.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92G53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03808 ; AAL03808 ; RC1270 .
    GeneIDi 928420.
    KEGGi rco:RC1270.
    PATRICi 17890054. VBIRicCon45613_1457.

    Phylogenomic databases

    eggNOGi COG1502.
    HOGENOMi HOG000222239.
    KOi K17717.
    OMAi ANNDKYT.
    OrthoDBi EOG6PW23S.

    Family and domain databases

    InterProi IPR025202. PLD-like_dom.
    IPR001736. PLipase_D/transphosphatidylase.
    [Graphical view ]
    Pfami PF13091. PLDc_2. 1 hit.
    [Graphical view ]
    SMARTi SM00155. PLDc. 1 hit.
    [Graphical view ]
    PROSITEi PS50035. PLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.
    2. "Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae."
      Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D.
      J. Infect. Dis. 188:1276-1283(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 58-77, FUNCTION, SUBUNIT, CATALYTIC ACTIVITY.
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiPLD_RICCN
    AccessioniPrimary (citable) accession number: Q92G53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3