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Q92G53

- PLD_RICCN

UniProt

Q92G53 - PLD_RICCN

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Protein

Phospholipase D

Gene
pld, RC1270
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Could be a virulence factor.1 Publication

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471 Reviewed prediction
Active sitei149 – 1491 Reviewed prediction
Active sitei154 – 1541 Reviewed prediction

GO - Molecular functioni

  1. N-acylphosphatidylethanolamine-specific phospholipase D activity Source: UniProtKB-EC
  2. phospholipase D activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D (EC:3.1.4.4)
Short name:
PLD
Alternative name(s):
Choline phosphatase
Gene namesi
Name:pld
Ordered Locus Names:RC1270
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 200175Phospholipase DPRO_0000274781Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi272944.RC1270.

Structurei

3D structure databases

ProteinModelPortaliQ92G53.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 16928PLD phosphodiesteraseAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1502.
HOGENOMiHOG000222239.
KOiK17717.
OMAiANNDKYT.
OrthoDBiEOG6PW23S.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92G53-1 [UniParc]FASTAAdd to Basket

« Hide

MKRKNNKFIE ISIAFILGIA LGLYGQNPDY FTNLISQKSL ALSALQIKHY    50
NISELSRSKV STCFTPPAGC TKFIANQIDK AEESIYMQAY GMSDALITTA 100
LINAQARGVK VRILLDRSNL KQKFSKLHEL QRAKIDVDID KVPGIAHNKV 150
IIIDKKKVIT GSFNFTAAAD KRNAENVIII EDQELAESYL QNWLNRKASN 200
Length:200
Mass (Da):22,418
Last modified:December 1, 2001 - v1
Checksum:iF878E8D78AF6E6F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03808.1.
PIRiF97858.
RefSeqiNP_360907.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03808; AAL03808; RC1270.
GeneIDi928420.
KEGGirco:RC1270.
PATRICi17890054. VBIRicCon45613_1457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03808.1 .
PIRi F97858.
RefSeqi NP_360907.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92G53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03808 ; AAL03808 ; RC1270 .
GeneIDi 928420.
KEGGi rco:RC1270.
PATRICi 17890054. VBIRicCon45613_1457.

Phylogenomic databases

eggNOGi COG1502.
HOGENOMi HOG000222239.
KOi K17717.
OMAi ANNDKYT.
OrthoDBi EOG6PW23S.

Family and domain databases

InterProi IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view ]
Pfami PF13091. PLDc_2. 1 hit.
[Graphical view ]
SMARTi SM00155. PLDc. 1 hit.
[Graphical view ]
PROSITEi PS50035. PLD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.
  2. "Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae."
    Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D.
    J. Infect. Dis. 188:1276-1283(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 58-77, FUNCTION, SUBUNIT, CATALYTIC ACTIVITY.
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiPLD_RICCN
AccessioniPrimary (citable) accession number: Q92G53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi