Reviewed, UniProtKB/Swiss-Prot Q92G53 (PLD_RICCN)

Names and origin

Protein names

Recommended name:
    Phospholipase D
      Short name=PLD
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase

Gene names

Name:	pld
Ordered Locus Names:	RC1270

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Could be a virulence factor. Ref.2
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate. Ref.2
Subunit structure	Homodimer. Ref.2
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 200	175	Phospholipase D		PRO_0000274781
Regions
	Domain	142 – 169	28	PLD phosphodiesterase
Sites
	Active site	147	1	Potential
	Active site	149	1	Potential
	Active site	154	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92G53-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F878E8D78AF6E6F5	FASTA	200	22,418
	10 20 30 40 50 60 MKRKNNKFIE ISIAFILGIA LGLYGQNPDY FTNLISQKSL ALSALQIKHY NISELSRSKV 70 80 90 100 110 120 STCFTPPAGC TKFIANQIDK AEESIYMQAY GMSDALITTA LINAQARGVK VRILLDRSNL 130 140 150 160 170 180 KQKFSKLHEL QRAKIDVDID KVPGIAHNKV IIIDKKKVIT GSFNFTAAAD KRNAENVIII 190 200 EDQELAESYL QNWLNRKASN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.
[2]	"Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae." Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D. J. Infect. Dis. 188:1276-1283(2003) [PubMed: 14593584] [Abstract] Cited for: PROTEIN SEQUENCE OF 58-77, FUNCTION, SUBUNIT, CATALYTIC ACTIVITY. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL03808.1.
PIR	F97858.
RefSeq	NP_360907.1.
3D structure databases
HSSP	HSSP built from PDB template 1BYR based on UniProtKB Q46707.
ModBase	Search...
Genome annotation databases
GeneID	928420.
GenomeReviews	Gene locus RC1270 in contig AE006914_GR.
KEGG	rco:RC1270.
NMPDR	fig|272944.1.peg.1270.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92G53.
OMA	TVPGIAH.
Enzyme and pathway databases
BioCyc	RCON272944:RC1270-MON.
BRENDA	3.1.4.4. 267518.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
SMART	SM00155. PLDc. 1 hit. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD_RICCN

Accession

Primary (citable) accession number: Q92G53

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)