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Q92G53 (PLD_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipase D

Short name=PLD
EC=3.1.4.4
Alternative name(s):
Choline phosphatase
Gene names
Name:pld
Ordered Locus Names:RC1270
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be a virulence factor. Ref.2

Catalytic activity

A phosphatidylcholine + H2O = choline + a phosphatidate. Ref.2

Subunit structure

Homodimer. Ref.2

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the phospholipase D family.

Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
Virulence
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAPE-specific phospholipase D activity

Inferred from electronic annotation. Source: UniProtKB-EC

phospholipase D activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 200175Phospholipase D
PRO_0000274781

Regions

Domain142 – 16928PLD phosphodiesterase

Sites

Active site1471 Potential
Active site1491 Potential
Active site1541 Potential

Sequences

Sequence LengthMass (Da)Tools
Q92G53 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F878E8D78AF6E6F5

FASTA20022,418
        10         20         30         40         50         60 
MKRKNNKFIE ISIAFILGIA LGLYGQNPDY FTNLISQKSL ALSALQIKHY NISELSRSKV 

        70         80         90        100        110        120 
STCFTPPAGC TKFIANQIDK AEESIYMQAY GMSDALITTA LINAQARGVK VRILLDRSNL 

       130        140        150        160        170        180 
KQKFSKLHEL QRAKIDVDID KVPGIAHNKV IIIDKKKVIT GSFNFTAAAD KRNAENVIII 

       190        200 
EDQELAESYL QNWLNRKASN 

« Hide

References

« Hide 'large scale' references
[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.
[2]"Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae."
Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D.
J. Infect. Dis. 188:1276-1283(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 58-77, FUNCTION, SUBUNIT, CATALYTIC ACTIVITY.
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03808.1.
PIRF97858.
RefSeqNP_360907.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92G53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03808; AAL03808; RC1270.
GeneID928420.
KEGGrco:RC1270.
PATRIC17890054. VBIRicCon45613_1457.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1502.
HOGENOMHOG000222239.
KOK17717.
OMAGLMHNKF.
OrthoDBEOG6PW23S.
ProtClustDBCLSK871092.

Family and domain databases

InterProIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLD_RICCN
AccessionPrimary (citable) accession number: Q92G53
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: January 22, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names