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Protein

Phospholipase D

Gene

pld

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be a virulence factor.1 Publication

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471PROSITE-ProRule annotation
Active sitei149 – 1491PROSITE-ProRule annotation
Active sitei154 – 1541PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D (EC:3.1.4.4)
Short name:
PLD
Alternative name(s):
Choline phosphatase
Gene namesi
Name:pld
Ordered Locus Names:RC1270
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 200175Phospholipase DPRO_0000274781Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ92G53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 16928PLD phosphodiesterasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family.Curated
Contains 1 PLD phosphodiesterase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1502.
HOGENOMiHOG000222239.
KOiK17717.
OMAiGLMHNKF.
OrthoDBiEOG6PW23S.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92G53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKNNKFIE ISIAFILGIA LGLYGQNPDY FTNLISQKSL ALSALQIKHY
60 70 80 90 100
NISELSRSKV STCFTPPAGC TKFIANQIDK AEESIYMQAY GMSDALITTA
110 120 130 140 150
LINAQARGVK VRILLDRSNL KQKFSKLHEL QRAKIDVDID KVPGIAHNKV
160 170 180 190 200
IIIDKKKVIT GSFNFTAAAD KRNAENVIII EDQELAESYL QNWLNRKASN
Length:200
Mass (Da):22,418
Last modified:December 1, 2001 - v1
Checksum:iF878E8D78AF6E6F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03808.1.
PIRiF97858.
RefSeqiNP_360907.1. NC_003103.1.
WP_010977832.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03808; AAL03808; RC1270.
GeneIDi928420.
KEGGirco:RC1270.
PATRICi17890054. VBIRicCon45613_1457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03808.1.
PIRiF97858.
RefSeqiNP_360907.1. NC_003103.1.
WP_010977832.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92G53.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL03808; AAL03808; RC1270.
GeneIDi928420.
KEGGirco:RC1270.
PATRICi17890054. VBIRicCon45613_1457.

Phylogenomic databases

eggNOGiCOG1502.
HOGENOMiHOG000222239.
KOiK17717.
OMAiGLMHNKF.
OrthoDBiEOG6PW23S.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.
  2. "Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae."
    Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D.
    J. Infect. Dis. 188:1276-1283(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 58-77, FUNCTION, SUBUNIT, CATALYTIC ACTIVITY.
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiPLD_RICCN
AccessioniPrimary (citable) accession number: Q92G53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.