Q92G53 (PLD_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase D
Short name=PLD
EC=3.1.4.4

Alternative name(s):
Choline phosphatase

Gene names

Name:	pld
Ordered Locus Names:	RC1270

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be a virulence factor. Ref.2
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate. Ref.2
Subunit structure	Homodimer. Ref.2
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological_process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 200	175	Phospholipase D		PRO_0000274781
Regions
	Domain	142 – 169	28	PLD phosphodiesterase
Sites
	Active site	147	1	Potential
	Active site	149	1	Potential
	Active site	154	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92G53 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F878E8D78AF6E6F5	FASTA	200	22,418
	10 20 30 40 50 60 MKRKNNKFIE ISIAFILGIA LGLYGQNPDY FTNLISQKSL ALSALQIKHY NISELSRSKV 70 80 90 100 110 120 STCFTPPAGC TKFIANQIDK AEESIYMQAY GMSDALITTA LINAQARGVK VRILLDRSNL 130 140 150 160 170 180 KQKFSKLHEL QRAKIDVDID KVPGIAHNKV IIIDKKKVIT GSFNFTAAAD KRNAENVIII 190 200 EDQELAESYL QNWLNRKASN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.
[2]	"Identification and characterization of a phospholipase D-superfamily gene in Rickettsiae." Renesto P., Dehoux P., Gouin E., Touqui L., Cossart P., Raoult D. J. Infect. Dis. 188:1276-1283(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 58-77, FUNCTION, SUBUNIT, CATALYTIC ACTIVITY. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03808.1.
PIR	F97858.
RefSeq	NP_360907.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92G53.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1270.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03808; AAL03808; RC1270.
GeneID	928420.
KEGG	rco:RC1270.
PATRIC	17890054. VBIRicCon45613_1457.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1502.
HOGENOM	HOG000222239.
OMA	DANLDIC.
ProtClustDB	CLSK871092.
Family and domain databases
InterPro	IPR025202. PLD-like_dom. IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
Pfam	PF13091. PLDc_2. 1 hit. [Graphical view]
SMART	SM00155. PLDc. 1 hit. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD_RICCN

Accession

Primary (citable) accession number: Q92G53

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program