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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi406 – 4116ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:RC1274
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 744582CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744DNA translocase FtsKPRO_0000098286Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92G50.
SMRiQ92G50. Positions 252-664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 605220FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiEYQNANL.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92G50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYINKILS NNKVQAVILG IIGLGIVIVL TSYNIDDPSF NSVTTEYHSN
60 70 80 90 100
LVGIFGSYLS DCLYQFFGLA AFIIPLACFV WGRNCWYGRY RGSFIRMFVM
110 120 130 140 150
LLALVSSSTL LSKIKLEFIP ANAGGAIGII ASNFFERFTN QLYLLLIFFT
160 170 180 190 200
FIILVVLFEI KFTSLSNFII KLGNFLIYRI QSFLHNVFSR LSSIRLFPTK
210 220 230 240 250
NNDKINITSS YQKPVSEKVK FPEEARSVPA NPIKFFSKPV SPKISQSEIA
260 270 280 290 300
ELPPISLLRD PEKHHVKGAS SLELKQKAEE LLTVLNDFGV KGQIININQG
310 320 330 340 350
PVVTQYEFEP AAGTKTSRVV GLSDDIARSL SALSTRIAVI PGKNVLGIEL
360 370 380 390 400
PNKQREFFCL KELIETPEYQ DKSTLLPLVL GKDLAGKPLV ADLAKMPHLL
410 420 430 440 450
VAGTTGSGKS VGINVMIVSL LYRYTPEECR FIMIDPKMLE LSAYDGIPHL
460 470 480 490 500
LTPVVTEPSK AVVALKWAVK EMENRYRMMS NIGVKNIAGY NAKILEAVKE
510 520 530 540 550
NRIIERSIQT GFDPETGKPI YETVTMKMEK LPYIVVIVDE MADLMLVAGK
560 570 580 590 600
DIEMLIQRLA QMARAAGIHI IMATQRPSVD VITGVIKANF PSRISFKVTS
610 620 630 640 650
KIDSRTILGE QGSEQLLGMG DMLFMGSTSK ISRVHGPFVN EAEIEQITEY
660 670 680 690 700
LKESGTPEYI SAVTEQPEED DSGIDIGDGT SDEVLYKKAV QIVRDERKSS
710 720 730 740
ISYIQRSLRI GYNKAANLVE KMEKEGIVSP PNHTGKREIL LPER
Length:744
Mass (Da):82,916
Last modified:December 1, 2001 - v1
Checksum:i99BE4E883051B921
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03812.1.
PIRiB97859.
RefSeqiWP_010977836.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03812; AAL03812; RC1274.
GeneIDi928426.
KEGGirco:RC1274.
PATRICi17890070. VBIRicCon45613_1465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03812.1.
PIRiB97859.
RefSeqiWP_010977836.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92G50.
SMRiQ92G50. Positions 252-664.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL03812; AAL03812; RC1274.
GeneIDi928426.
KEGGirco:RC1274.
PATRICi17890070. VBIRicCon45613_1465.

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiEYQNANL.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiFTSK_RICCN
AccessioniPrimary (citable) accession number: Q92G50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.