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Q92G50 (FTSK_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA translocase FtsK
Gene names
Name:ftsK
Ordered Locus Names:RC1274
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.

Subunit structure

Homohexamer. Forms a ring that surrounds DNA By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity. Note: Located at the septum By similarity.

Domain

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.

Sequence similarities

Belongs to the FtsK/SpoIIIE/SftA family.

Contains 1 FtsK domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744DNA translocase FtsK
PRO_0000098286

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 744582Cytoplasmic Potential
Domain386 – 605220FtsK
Nucleotide binding406 – 4116ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92G50 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 99BE4E883051B921

FASTA74482,916
        10         20         30         40         50         60 
MLYYINKILS NNKVQAVILG IIGLGIVIVL TSYNIDDPSF NSVTTEYHSN LVGIFGSYLS 

        70         80         90        100        110        120 
DCLYQFFGLA AFIIPLACFV WGRNCWYGRY RGSFIRMFVM LLALVSSSTL LSKIKLEFIP 

       130        140        150        160        170        180 
ANAGGAIGII ASNFFERFTN QLYLLLIFFT FIILVVLFEI KFTSLSNFII KLGNFLIYRI 

       190        200        210        220        230        240 
QSFLHNVFSR LSSIRLFPTK NNDKINITSS YQKPVSEKVK FPEEARSVPA NPIKFFSKPV 

       250        260        270        280        290        300 
SPKISQSEIA ELPPISLLRD PEKHHVKGAS SLELKQKAEE LLTVLNDFGV KGQIININQG 

       310        320        330        340        350        360 
PVVTQYEFEP AAGTKTSRVV GLSDDIARSL SALSTRIAVI PGKNVLGIEL PNKQREFFCL 

       370        380        390        400        410        420 
KELIETPEYQ DKSTLLPLVL GKDLAGKPLV ADLAKMPHLL VAGTTGSGKS VGINVMIVSL 

       430        440        450        460        470        480 
LYRYTPEECR FIMIDPKMLE LSAYDGIPHL LTPVVTEPSK AVVALKWAVK EMENRYRMMS 

       490        500        510        520        530        540 
NIGVKNIAGY NAKILEAVKE NRIIERSIQT GFDPETGKPI YETVTMKMEK LPYIVVIVDE 

       550        560        570        580        590        600 
MADLMLVAGK DIEMLIQRLA QMARAAGIHI IMATQRPSVD VITGVIKANF PSRISFKVTS 

       610        620        630        640        650        660 
KIDSRTILGE QGSEQLLGMG DMLFMGSTSK ISRVHGPFVN EAEIEQITEY LKESGTPEYI 

       670        680        690        700        710        720 
SAVTEQPEED DSGIDIGDGT SDEVLYKKAV QIVRDERKSS ISYIQRSLRI GYNKAANLVE 

       730        740 
KMEKEGIVSP PNHTGKREIL LPER 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03812.1.
PIRB97859.
RefSeqNP_360911.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92G50.
SMRQ92G50. Positions 252-664.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1274.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03812; AAL03812; RC1274.
GeneID928426.
KEGGrco:RC1274.
PATRIC17890070. VBIRicCon45613_1465.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1674.
HOGENOMHOG000010003.
KOK03466.
OMAPNKEREI.
OrthoDBEOG6S52GD.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR002543. Cell_div_FtsK/SpoIIIE.
IPR018541. DNA_translocase_Ftsk_gamma.
IPR025199. DUF4117.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSK_RICCN
AccessionPrimary (citable) accession number: Q92G50
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names