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Q92G50

- FTSK_RICCN

UniProt

Q92G50 - FTSK_RICCN

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Protein

DNA translocase FtsK

Gene
ftsK, RC1274
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi406 – 4116ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:RC1274
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cell inner membrane; Multi-pass membrane protein By similarity
Note: Located at the septum By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Reviewed predictionAdd
BLAST
Transmembranei92 – 11221Helical; Reviewed predictionAdd
BLAST
Transmembranei116 – 13621Helical; Reviewed predictionAdd
BLAST
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Topological domaini163 – 744582Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744DNA translocase FtsKPRO_0000098286Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA By similarity.

Protein-protein interaction databases

STRINGi272944.RC1274.

Structurei

3D structure databases

ProteinModelPortaliQ92G50.
SMRiQ92G50. Positions 252-664.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 605220FtsKAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.
Contains 1 FtsK domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiPNKEREI.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92G50-1 [UniParc]FASTAAdd to Basket

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MLYYINKILS NNKVQAVILG IIGLGIVIVL TSYNIDDPSF NSVTTEYHSN    50
LVGIFGSYLS DCLYQFFGLA AFIIPLACFV WGRNCWYGRY RGSFIRMFVM 100
LLALVSSSTL LSKIKLEFIP ANAGGAIGII ASNFFERFTN QLYLLLIFFT 150
FIILVVLFEI KFTSLSNFII KLGNFLIYRI QSFLHNVFSR LSSIRLFPTK 200
NNDKINITSS YQKPVSEKVK FPEEARSVPA NPIKFFSKPV SPKISQSEIA 250
ELPPISLLRD PEKHHVKGAS SLELKQKAEE LLTVLNDFGV KGQIININQG 300
PVVTQYEFEP AAGTKTSRVV GLSDDIARSL SALSTRIAVI PGKNVLGIEL 350
PNKQREFFCL KELIETPEYQ DKSTLLPLVL GKDLAGKPLV ADLAKMPHLL 400
VAGTTGSGKS VGINVMIVSL LYRYTPEECR FIMIDPKMLE LSAYDGIPHL 450
LTPVVTEPSK AVVALKWAVK EMENRYRMMS NIGVKNIAGY NAKILEAVKE 500
NRIIERSIQT GFDPETGKPI YETVTMKMEK LPYIVVIVDE MADLMLVAGK 550
DIEMLIQRLA QMARAAGIHI IMATQRPSVD VITGVIKANF PSRISFKVTS 600
KIDSRTILGE QGSEQLLGMG DMLFMGSTSK ISRVHGPFVN EAEIEQITEY 650
LKESGTPEYI SAVTEQPEED DSGIDIGDGT SDEVLYKKAV QIVRDERKSS 700
ISYIQRSLRI GYNKAANLVE KMEKEGIVSP PNHTGKREIL LPER 744
Length:744
Mass (Da):82,916
Last modified:December 1, 2001 - v1
Checksum:i99BE4E883051B921
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03812.1.
PIRiB97859.
RefSeqiNP_360911.1. NC_003103.1.
WP_010977836.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03812; AAL03812; RC1274.
GeneIDi928426.
KEGGirco:RC1274.
PATRICi17890070. VBIRicCon45613_1465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03812.1 .
PIRi B97859.
RefSeqi NP_360911.1. NC_003103.1.
WP_010977836.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92G50.
SMRi Q92G50. Positions 252-664.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1274.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03812 ; AAL03812 ; RC1274 .
GeneIDi 928426.
KEGGi rco:RC1274.
PATRICi 17890070. VBIRicCon45613_1465.

Phylogenomic databases

eggNOGi COG1674.
HOGENOMi HOG000010003.
KOi K03466.
OMAi PNKEREI.
OrthoDBi EOG6S52GD.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50901. FTSK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiFTSK_RICCN
AccessioniPrimary (citable) accession number: Q92G50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi