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Q92G50

- FTSK_RICCN

UniProt

Q92G50 - FTSK_RICCN

Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi406 – 4116ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA translocase FtsK
    Gene namesi
    Name:ftsK
    Ordered Locus Names:RC1274
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Multi-pass membrane protein By similarity
    Note: Located at the septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744DNA translocase FtsKPRO_0000098286Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Forms a ring that surrounds DNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi272944.RC1274.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92G50.
    SMRiQ92G50. Positions 252-664.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini163 – 744582CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini386 – 605220FtsKPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FtsK/SpoIIIE/SftA family.Curated
    Contains 1 FtsK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1674.
    HOGENOMiHOG000010003.
    KOiK03466.
    OMAiPNKEREI.
    OrthoDBiEOG6S52GD.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50901. FTSK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92G50-1 [UniParc]FASTAAdd to Basket

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    MLYYINKILS NNKVQAVILG IIGLGIVIVL TSYNIDDPSF NSVTTEYHSN    50
    LVGIFGSYLS DCLYQFFGLA AFIIPLACFV WGRNCWYGRY RGSFIRMFVM 100
    LLALVSSSTL LSKIKLEFIP ANAGGAIGII ASNFFERFTN QLYLLLIFFT 150
    FIILVVLFEI KFTSLSNFII KLGNFLIYRI QSFLHNVFSR LSSIRLFPTK 200
    NNDKINITSS YQKPVSEKVK FPEEARSVPA NPIKFFSKPV SPKISQSEIA 250
    ELPPISLLRD PEKHHVKGAS SLELKQKAEE LLTVLNDFGV KGQIININQG 300
    PVVTQYEFEP AAGTKTSRVV GLSDDIARSL SALSTRIAVI PGKNVLGIEL 350
    PNKQREFFCL KELIETPEYQ DKSTLLPLVL GKDLAGKPLV ADLAKMPHLL 400
    VAGTTGSGKS VGINVMIVSL LYRYTPEECR FIMIDPKMLE LSAYDGIPHL 450
    LTPVVTEPSK AVVALKWAVK EMENRYRMMS NIGVKNIAGY NAKILEAVKE 500
    NRIIERSIQT GFDPETGKPI YETVTMKMEK LPYIVVIVDE MADLMLVAGK 550
    DIEMLIQRLA QMARAAGIHI IMATQRPSVD VITGVIKANF PSRISFKVTS 600
    KIDSRTILGE QGSEQLLGMG DMLFMGSTSK ISRVHGPFVN EAEIEQITEY 650
    LKESGTPEYI SAVTEQPEED DSGIDIGDGT SDEVLYKKAV QIVRDERKSS 700
    ISYIQRSLRI GYNKAANLVE KMEKEGIVSP PNHTGKREIL LPER 744
    Length:744
    Mass (Da):82,916
    Last modified:December 1, 2001 - v1
    Checksum:i99BE4E883051B921
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03812.1.
    PIRiB97859.
    RefSeqiNP_360911.1. NC_003103.1.
    WP_010977836.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03812; AAL03812; RC1274.
    GeneIDi928426.
    KEGGirco:RC1274.
    PATRICi17890070. VBIRicCon45613_1465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03812.1 .
    PIRi B97859.
    RefSeqi NP_360911.1. NC_003103.1.
    WP_010977836.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92G50.
    SMRi Q92G50. Positions 252-664.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1274.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03812 ; AAL03812 ; RC1274 .
    GeneIDi 928426.
    KEGGi rco:RC1274.
    PATRICi 17890070. VBIRicCon45613_1465.

    Phylogenomic databases

    eggNOGi COG1674.
    HOGENOMi HOG000010003.
    KOi K03466.
    OMAi PNKEREI.
    OrthoDBi EOG6S52GD.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50901. FTSK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiFTSK_RICCN
    AccessioniPrimary (citable) accession number: Q92G50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3