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Q92G31 (UVRA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein A

Short name=UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene names
Name:uvrA
Ordered Locus Names:RC1294
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP-Rule MF_00205

Subunit structure

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00205.

Sequence similarities

Belongs to the ABC transporter superfamily. UvrA family.

Contains 2 ABC transporter domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955UvrABC system protein A HAMAP-Rule MF_00205
PRO_0000093083

Regions

Domain322 – 601280ABC transporter 1
Domain621 – 951331ABC transporter 2
Nucleotide binding35 – 428ATP Potential
Nucleotide binding654 – 6618ATP Potential
Zinc finger754 – 78027C4-type HAMAP-Rule MF_00205

Sequences

Sequence LengthMass (Da)Tools
Q92G31 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 70ED64A253D7FA68

FASTA955106,317
        10         20         30         40         50         60 
MIMNQEYIKV RGAKEHNLKN INVNIPRNKF VVITGLSGSG KSSLAFDTIY AEGQRRYVES 

        70         80         90        100        110        120 
LSSYARQFLH LQNKPNVESI SGLSPAIAID QKTTSKNPRS TVGTITEIYD YLRLLYARVG 

       130        140        150        160        170        180 
IPYSPATGLP IHSQTVSEMV DIINELPKGT KIYLLAPIVR GHKGEFKREI MDLKKQGFQK 

       190        200        210        220        230        240 
LIVNGEVCEI DDLPKLDKNK KHNIEVIVDR IVLDESLGNR LADSLESSLN LAEGITYLEI 

       250        260        270        280        290        300 
VELPPAVKSE FEKNQRITFS EQYSCPVSGF QLTEIEPRIF SFNSPFGACP KCEGIGKEFF 

       310        320        330        340        350        360 
FDRDLIVPDQ RIAIKDGAIV PWGSTASKFI LETLKALADH YKFSIEVPFV SLSQNVKDIL 

       370        380        390        400        410        420 
FEGSGEEAIK FEFHDGSKTQ IIKQPFAGII PSLQEKDRTI ESVLIKEELA KFKSEHKCTA 

       430        440        450        460        470        480 
CSGFRLKDEA LCVKIANLHI GEVAGMSIAA LQKWFSHLEE KLNKKQLFIA ERILKEITER 

       490        500        510        520        530        540 
LKFLMNVGLD YLTLSREAGT LSGGESQRIR LASQIGSGLS GVLYVLDEPS IGLHQRDNTR 

       550        560        570        580        590        600 
LIETLKRLRD LGNTVLVVEH DEETIYEADH IIDIGPGAGI HGGRVIAEGN VEEIKNFEES 

       610        620        630        640        650        660 
ITGRYLSGRQ TIKVPSETRV GHDNRAIELL GAVSNNLDNV DIKIPLGTFT AITGVSGSGK 

       670        680        690        700        710        720 
SSLMIHTLYK AALKHLEPTS KVFPGKYREL KGLEYIDKII DINQSPIGRT PRSNPATYTG 

       730        740        750        760        770        780 
AFTHIRDWFV ELPESKARGY KVGRFSFNVK GGRCEACQGD GLIKIEMHFL PDVYVKCDIC 

       790        800        810        820        830        840 
NGHRYNRETL EIKYKGKSIA DILMMTVEDA MQFFEKIPLI YEKLITLNEV GLGYIKIGQS 

       850        860        870        880        890        900 
ATTLSGGEAQ RVKLAKELSR RSTGKTLYIL DEPTTGLHID DINKLLKVLH KLVDMGNTVL 

       910        920        930        940        950 
VIEHNLDVIK TADYIIDVGP EGGDKGGKIV VCGTPADIAA CEESHTGRYL KQYLV 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03832.1.
PIRF97861.
RefSeqNP_360931.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92G31.
SMRQ92G31. Positions 6-954.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1294.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03832; AAL03832; RC1294.
GeneID928444.
KEGGrco:RC1294.
PATRIC17890112. VBIRicCon45613_1486.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0178.
HOGENOMHOG000050448.
KOK03701.
OMAEGVLNNM.
OrthoDBEOG6QK4PS.

Family and domain databases

Gene3D3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPMF_00205. UvrA.
InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
TIGRFAMsTIGR00630. uvra. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRA_RICCN
AccessionPrimary (citable) accession number: Q92G31
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names