UvrABC system protein A - Rickettsia conorii (strain ATCC VR-613 / Malish 7)

Preferred order of sections

Names and origin

Protein names

Recommended name:
UvrABC system protein A
Short name=UvrA protein

Alternative name(s):
Excinuclease ABC subunit A

Gene names

Name:	uvrA
Ordered Locus Names:	RC1294

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group ›

Protein attributes

Sequence length	955 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP-Rule MF_00205
Subunit structure	Forms a heterotetramer with UvrB during the search for lesions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. UvrA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Domain	Repeat Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC SOS response Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 955

955

UvrABC system protein A HAMAP-Rule MF_00205

PRO_0000093083

Regions

Domain

347 – 601

255

ABC transporter 1

Domain

612 – 951

340

ABC transporter 2

Nucleotide binding

35 – 42

8

ATP Potential

Nucleotide binding

654 – 661

8

ATP Potential

Zinc finger

754 – 780

27

C4-type HAMAP-Rule MF_00205

Sequences

Sequence

Length

Mass (Da)

Tools

Q92G31 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 70ED64A253D7FA68
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FASTA

955

106,317

        10         20         30         40         50         60 
MIMNQEYIKV RGAKEHNLKN INVNIPRNKF VVITGLSGSG KSSLAFDTIY AEGQRRYVES 

        70         80         90        100        110        120 
LSSYARQFLH LQNKPNVESI SGLSPAIAID QKTTSKNPRS TVGTITEIYD YLRLLYARVG 

       130        140        150        160        170        180 
IPYSPATGLP IHSQTVSEMV DIINELPKGT KIYLLAPIVR GHKGEFKREI MDLKKQGFQK 

       190        200        210        220        230        240 
LIVNGEVCEI DDLPKLDKNK KHNIEVIVDR IVLDESLGNR LADSLESSLN LAEGITYLEI 

       250        260        270        280        290        300 
VELPPAVKSE FEKNQRITFS EQYSCPVSGF QLTEIEPRIF SFNSPFGACP KCEGIGKEFF 

       310        320        330        340        350        360 
FDRDLIVPDQ RIAIKDGAIV PWGSTASKFI LETLKALADH YKFSIEVPFV SLSQNVKDIL 

       370        380        390        400        410        420 
FEGSGEEAIK FEFHDGSKTQ IIKQPFAGII PSLQEKDRTI ESVLIKEELA KFKSEHKCTA 

       430        440        450        460        470        480 
CSGFRLKDEA LCVKIANLHI GEVAGMSIAA LQKWFSHLEE KLNKKQLFIA ERILKEITER 

       490        500        510        520        530        540 
LKFLMNVGLD YLTLSREAGT LSGGESQRIR LASQIGSGLS GVLYVLDEPS IGLHQRDNTR 

       550        560        570        580        590        600 
LIETLKRLRD LGNTVLVVEH DEETIYEADH IIDIGPGAGI HGGRVIAEGN VEEIKNFEES 

       610        620        630        640        650        660 
ITGRYLSGRQ TIKVPSETRV GHDNRAIELL GAVSNNLDNV DIKIPLGTFT AITGVSGSGK 

       670        680        690        700        710        720 
SSLMIHTLYK AALKHLEPTS KVFPGKYREL KGLEYIDKII DINQSPIGRT PRSNPATYTG 

       730        740        750        760        770        780 
AFTHIRDWFV ELPESKARGY KVGRFSFNVK GGRCEACQGD GLIKIEMHFL PDVYVKCDIC 

       790        800        810        820        830        840 
NGHRYNRETL EIKYKGKSIA DILMMTVEDA MQFFEKIPLI YEKLITLNEV GLGYIKIGQS 

       850        860        870        880        890        900 
ATTLSGGEAQ RVKLAKELSR RSTGKTLYIL DEPTTGLHID DINKLLKVLH KLVDMGNTVL 

       910        920        930        940        950 
VIEHNLDVIK TADYIIDVGP EGGDKGGKIV VCGTPADIAA CEESHTGRYL KQYLV

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References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03832.1.
PIR	F97861.
RefSeq	NP_360931.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92G31.
SMR	Q92G31. Positions 6-954.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1294.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03832; AAL03832; RC1294.
GeneID	928444.
KEGG	rco:RC1294.
PATRIC	17890112. VBIRicCon45613_1486.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0178.
HOGENOM	HOG000050448.
KO	K03701.
OMA	GAIKGWD.
ProtClustDB	PRK00349.
Family and domain databases
Gene3D	3.30.1490.20. 2 hits.
HAMAP	MF_00205. UvrA.
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013815. ATP_grasp_subdomain_1. IPR004602. UvrA. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
TIGRFAMs	TIGR00630. uvra. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRA_RICCN

Accession

Primary (citable) accession number: Q92G31

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Rickettsia conorii

(strain Malish 7): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents