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Q92G31

- UVRA_RICCN

UniProt

Q92G31 - UVRA_RICCN

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Protein
UvrABC system protein A
Gene
uvrA, RC1294
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 428ATP Reviewed prediction
Nucleotide bindingi654 – 6618ATP Reviewed prediction
Zinc fingeri754 – 78027C4-typeUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATPase activity Source: InterPro
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein A
Short name:
UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene namesi
Name:uvrA
Ordered Locus Names:RC1294
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955UvrABC system protein AUniRule annotation
PRO_0000093083Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Protein-protein interaction databases

STRINGi272944.RC1294.

Structurei

3D structure databases

ProteinModelPortaliQ92G31.
SMRiQ92G31. Positions 6-954.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 601280ABC transporter 1
Add
BLAST
Domaini621 – 951331ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
HOGENOMiHOG000050448.
KOiK03701.
OMAiEGVLNNM.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92G31-1 [UniParc]FASTAAdd to Basket

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MIMNQEYIKV RGAKEHNLKN INVNIPRNKF VVITGLSGSG KSSLAFDTIY    50
AEGQRRYVES LSSYARQFLH LQNKPNVESI SGLSPAIAID QKTTSKNPRS 100
TVGTITEIYD YLRLLYARVG IPYSPATGLP IHSQTVSEMV DIINELPKGT 150
KIYLLAPIVR GHKGEFKREI MDLKKQGFQK LIVNGEVCEI DDLPKLDKNK 200
KHNIEVIVDR IVLDESLGNR LADSLESSLN LAEGITYLEI VELPPAVKSE 250
FEKNQRITFS EQYSCPVSGF QLTEIEPRIF SFNSPFGACP KCEGIGKEFF 300
FDRDLIVPDQ RIAIKDGAIV PWGSTASKFI LETLKALADH YKFSIEVPFV 350
SLSQNVKDIL FEGSGEEAIK FEFHDGSKTQ IIKQPFAGII PSLQEKDRTI 400
ESVLIKEELA KFKSEHKCTA CSGFRLKDEA LCVKIANLHI GEVAGMSIAA 450
LQKWFSHLEE KLNKKQLFIA ERILKEITER LKFLMNVGLD YLTLSREAGT 500
LSGGESQRIR LASQIGSGLS GVLYVLDEPS IGLHQRDNTR LIETLKRLRD 550
LGNTVLVVEH DEETIYEADH IIDIGPGAGI HGGRVIAEGN VEEIKNFEES 600
ITGRYLSGRQ TIKVPSETRV GHDNRAIELL GAVSNNLDNV DIKIPLGTFT 650
AITGVSGSGK SSLMIHTLYK AALKHLEPTS KVFPGKYREL KGLEYIDKII 700
DINQSPIGRT PRSNPATYTG AFTHIRDWFV ELPESKARGY KVGRFSFNVK 750
GGRCEACQGD GLIKIEMHFL PDVYVKCDIC NGHRYNRETL EIKYKGKSIA 800
DILMMTVEDA MQFFEKIPLI YEKLITLNEV GLGYIKIGQS ATTLSGGEAQ 850
RVKLAKELSR RSTGKTLYIL DEPTTGLHID DINKLLKVLH KLVDMGNTVL 900
VIEHNLDVIK TADYIIDVGP EGGDKGGKIV VCGTPADIAA CEESHTGRYL 950
KQYLV 955
Length:955
Mass (Da):106,317
Last modified:December 1, 2001 - v1
Checksum:i70ED64A253D7FA68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03832.1.
PIRiF97861.
RefSeqiNP_360931.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03832; AAL03832; RC1294.
GeneIDi928444.
KEGGirco:RC1294.
PATRICi17890112. VBIRicCon45613_1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03832.1 .
PIRi F97861.
RefSeqi NP_360931.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92G31.
SMRi Q92G31. Positions 6-954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03832 ; AAL03832 ; RC1294 .
GeneIDi 928444.
KEGGi rco:RC1294.
PATRICi 17890112. VBIRicCon45613_1486.

Phylogenomic databases

eggNOGi COG0178.
HOGENOMi HOG000050448.
KOi K03701.
OMAi EGVLNNM.
OrthoDBi EOG6QK4PS.

Family and domain databases

Gene3Di 3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPi MF_00205. UvrA.
InterProi IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00630. uvra. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiUVRA_RICCN
AccessioniPrimary (citable) accession number: Q92G31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi