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Q92G31

- UVRA_RICCN

UniProt

Q92G31 - UVRA_RICCN

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Protein

UvrABC system protein A

Gene

uvrA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 428ATPUniRule annotation
Nucleotide bindingi654 – 6618ATPUniRule annotation
Zinc fingeri754 – 78027C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:RC1294
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955UvrABC system protein APRO_0000093083Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC1294.

Structurei

3D structure databases

ProteinModelPortaliQ92G31.
SMRiQ92G31. Positions 6-954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini322 – 601280ABC transporter 1UniRule annotationAdd
BLAST
Domaini621 – 951331ABC transporter 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
Contains 2 ABC transporter domains.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri754 – 78027C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
HOGENOMiHOG000050448.
KOiK03701.
OMAiEGVLNNM.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92G31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMNQEYIKV RGAKEHNLKN INVNIPRNKF VVITGLSGSG KSSLAFDTIY
60 70 80 90 100
AEGQRRYVES LSSYARQFLH LQNKPNVESI SGLSPAIAID QKTTSKNPRS
110 120 130 140 150
TVGTITEIYD YLRLLYARVG IPYSPATGLP IHSQTVSEMV DIINELPKGT
160 170 180 190 200
KIYLLAPIVR GHKGEFKREI MDLKKQGFQK LIVNGEVCEI DDLPKLDKNK
210 220 230 240 250
KHNIEVIVDR IVLDESLGNR LADSLESSLN LAEGITYLEI VELPPAVKSE
260 270 280 290 300
FEKNQRITFS EQYSCPVSGF QLTEIEPRIF SFNSPFGACP KCEGIGKEFF
310 320 330 340 350
FDRDLIVPDQ RIAIKDGAIV PWGSTASKFI LETLKALADH YKFSIEVPFV
360 370 380 390 400
SLSQNVKDIL FEGSGEEAIK FEFHDGSKTQ IIKQPFAGII PSLQEKDRTI
410 420 430 440 450
ESVLIKEELA KFKSEHKCTA CSGFRLKDEA LCVKIANLHI GEVAGMSIAA
460 470 480 490 500
LQKWFSHLEE KLNKKQLFIA ERILKEITER LKFLMNVGLD YLTLSREAGT
510 520 530 540 550
LSGGESQRIR LASQIGSGLS GVLYVLDEPS IGLHQRDNTR LIETLKRLRD
560 570 580 590 600
LGNTVLVVEH DEETIYEADH IIDIGPGAGI HGGRVIAEGN VEEIKNFEES
610 620 630 640 650
ITGRYLSGRQ TIKVPSETRV GHDNRAIELL GAVSNNLDNV DIKIPLGTFT
660 670 680 690 700
AITGVSGSGK SSLMIHTLYK AALKHLEPTS KVFPGKYREL KGLEYIDKII
710 720 730 740 750
DINQSPIGRT PRSNPATYTG AFTHIRDWFV ELPESKARGY KVGRFSFNVK
760 770 780 790 800
GGRCEACQGD GLIKIEMHFL PDVYVKCDIC NGHRYNRETL EIKYKGKSIA
810 820 830 840 850
DILMMTVEDA MQFFEKIPLI YEKLITLNEV GLGYIKIGQS ATTLSGGEAQ
860 870 880 890 900
RVKLAKELSR RSTGKTLYIL DEPTTGLHID DINKLLKVLH KLVDMGNTVL
910 920 930 940 950
VIEHNLDVIK TADYIIDVGP EGGDKGGKIV VCGTPADIAA CEESHTGRYL

KQYLV
Length:955
Mass (Da):106,317
Last modified:December 1, 2001 - v1
Checksum:i70ED64A253D7FA68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03832.1.
PIRiF97861.
RefSeqiNP_360931.1. NC_003103.1.
WP_010977854.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03832; AAL03832; RC1294.
GeneIDi928444.
KEGGirco:RC1294.
PATRICi17890112. VBIRicCon45613_1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03832.1 .
PIRi F97861.
RefSeqi NP_360931.1. NC_003103.1.
WP_010977854.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92G31.
SMRi Q92G31. Positions 6-954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03832 ; AAL03832 ; RC1294 .
GeneIDi 928444.
KEGGi rco:RC1294.
PATRICi 17890112. VBIRicCon45613_1486.

Phylogenomic databases

eggNOGi COG0178.
HOGENOMi HOG000050448.
KOi K03701.
OMAi EGVLNNM.
OrthoDBi EOG6QK4PS.

Family and domain databases

Gene3Di 3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPi MF_00205. UvrA.
InterProi IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00630. uvra. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiUVRA_RICCN
AccessioniPrimary (citable) accession number: Q92G31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3