Reviewed, UniProtKB/Swiss-Prot Q92G23 (HEM1_RICCN)

Names and origin

Protein names

Recommended name:
    5-aminolevulinate synthase
    EC=2.3.1.37
Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-aminolevulinate synthase
    Delta-ALA synthase

Gene names

Name:	hemA
Ordered Locus Names:	RC1303

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Heme biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-aminolevulinate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	5-aminolevulinate synthase		PRO_0000280897
Amino acid modifications
	Modified residue	244	1	N6-(pyridoxal phosphate)lysine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q92G23-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: D6E5838194CE8504	FASTA	414	46,238
	10 20 30 40 50 60 MSYYDIIFSK HIDKIKSEGR YREFKALKRQ ADNFPFAEHA NKQIVMWCIN DYLGMSKHAK 70 80 90 100 110 120 VMHASIDALL KYGVGSGGTR NIGGNNIAIL ELEKELANLH KKQAALVFTS GFVANDTTLA 130 140 150 160 170 180 SLAKIMPDIV FFSDELNHAS IIAGITSSRA EKYIYRHLDV KHLEELLQSV DINRPKIVVF 190 200 210 220 230 240 ESAYSMDGFF SPIKDIINLA KKYNALTFID EVHTVGLYGK QGGGIAELLN CSDQIDIIQG 250 260 270 280 290 300 TLAKAYGTIG GYITSNHNLV DAIRLTAPGF IFTTSLPPVI STAATHSIRH LKESNEERIK 310 320 330 340 350 360 HQEVVTKLKN SFERFNIPYL KNESHIVPII IGDPIKTAKA SNMLLNEYGI YVQHINFPTV 370 380 390 400 410 PRGTERLRII PTPAHTDKMI NDLSVALVQI FAELDIELSS AKELNEEVRL NLIA

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03841.1. Different initiation.
PIR	G97862.
RefSeq	NP_360940.1.
3D structure databases
HSSP	HSSP built from PDB template 2BWN based on UniProtKB P18079.
SMR	Q92G23. Positions 4-391.
ModBase	Search...
Genome annotation databases
GeneID	928451.
GenomeReviews	Gene locus RC1303 in contig AE006914_GR.
KEGG	rco:RC1303.
NMPDR	fig|272944.1.peg.1303.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HLKESNE.
Enzyme and pathway databases
BioCyc	RCON272944:RC1303-MONOMER.
BRENDA	2.3.1.37. 267518.
Family and domain databases
InterPro	IPR010961. 4pyrrol_synth_NH2levulA_synth. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01821. 5aminolev_synth. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM1_RICCN

Accession

Primary (citable) accession number: Q92G23

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	February 9, 2010
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)