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Q92G23

- HEM1_RICCN

UniProt

Q92G23 - HEM1_RICCN

Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221SubstrateBy similarity
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei185 – 1851Pyridoxal phosphateBy similarity
    Binding sitei213 – 2131Pyridoxal phosphateBy similarity
    Binding sitei241 – 2411Pyridoxal phosphateBy similarity
    Active sitei244 – 2441By similarity
    Binding sitei273 – 2731Pyridoxal phosphateBy similarity
    Binding sitei274 – 2741Pyridoxal phosphateBy similarity
    Binding sitei359 – 3591SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hemA
    Ordered Locus Names:RC1303
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4144145-aminolevulinate synthasePRO_0000280897Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei244 – 2441N6-(pyridoxal phosphate)lysineCurated

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC1303.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92G23.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiHYLQSIN.
    OrthoDBiEOG6Q8HZD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92G23-1 [UniParc]FASTAAdd to Basket

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    MSYYDIIFSK HIDKIKSEGR YREFKALKRQ ADNFPFAEHA NKQIVMWCIN    50
    DYLGMSKHAK VMHASIDALL KYGVGSGGTR NIGGNNIAIL ELEKELANLH 100
    KKQAALVFTS GFVANDTTLA SLAKIMPDIV FFSDELNHAS IIAGITSSRA 150
    EKYIYRHLDV KHLEELLQSV DINRPKIVVF ESAYSMDGFF SPIKDIINLA 200
    KKYNALTFID EVHTVGLYGK QGGGIAELLN CSDQIDIIQG TLAKAYGTIG 250
    GYITSNHNLV DAIRLTAPGF IFTTSLPPVI STAATHSIRH LKESNEERIK 300
    HQEVVTKLKN SFERFNIPYL KNESHIVPII IGDPIKTAKA SNMLLNEYGI 350
    YVQHINFPTV PRGTERLRII PTPAHTDKMI NDLSVALVQI FAELDIELSS 400
    AKELNEEVRL NLIA 414
    Length:414
    Mass (Da):46,238
    Last modified:March 20, 2007 - v2
    Checksum:iD6E5838194CE8504
    GO

    Sequence cautioni

    The sequence AAL03841.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03841.1. Different initiation.
    PIRiG97862.
    RefSeqiNP_360940.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03841; AAL03841; RC1303.
    GeneIDi928451.
    KEGGirco:RC1303.
    PATRICi17890133. VBIRicCon45613_1495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03841.1 . Different initiation.
    PIRi G97862.
    RefSeqi NP_360940.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92G23.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1303.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03841 ; AAL03841 ; RC1303 .
    GeneIDi 928451.
    KEGGi rco:RC1303.
    PATRICi 17890133. VBIRicCon45613_1495.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi HYLQSIN.
    OrthoDBi EOG6Q8HZD.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiHEM1_RICCN
    AccessioniPrimary (citable) accession number: Q92G23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3