ID   MUTL_RICCN              Reviewed;         610 AA.
AC   Q92FW6;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RC1361;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE006914; AAL03899.1; -; Genomic_DNA.
DR   PIR; A97870; A97870.
DR   RefSeq; WP_010977912.1; NC_003103.1.
DR   AlphaFoldDB; Q92FW6; -.
DR   SMR; Q92FW6; -.
DR   GeneID; 928512; -.
DR   KEGG; rco:RC1361; -.
DR   PATRIC; fig|272944.4.peg.1562; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd00782; MutL_Trans; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..610
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177964"
SQ   SEQUENCE   610 AA;  68921 MW;  E8ED4C7FFE2316BF CRC64;
     MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG KNLIIISDDG
     IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS IAAISKMLIT SKKRDADKAF
     QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELTATV DVVKKIALAH
     PKISFSLTHD GKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT
     SSPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPICAIF LQIDPQLVDV
     NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDVLELFKN PLVNKQSPVS
     KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK IEQEVENRIE HEQQTRKQYK
     LGAAKAQLHT TYIISQTEDS IVITDQHAAH ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL
     PNEKKADCLY DHREKLYKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG
     KNIALTELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK
     LKDIERLFGR
//