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Q92FW6

- MUTL_RICCN

UniProt

Q92FW6 - MUTL_RICCN

Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutLUniRule annotation
    Gene namesi
    Name:mutLUniRule annotation
    Ordered Locus Names:RC1361
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. mismatch repair complex Source: InterPro
    2. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 610610DNA mismatch repair protein MutLPRO_0000177964Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC1361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92FW6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0323.
    HOGENOMiHOG000256550.
    KOiK03572.
    OMAiGTYILAQ.
    OrthoDBiEOG6P8TMH.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.565.10. 1 hit.
    HAMAPiMF_00149. DNA_mis_repair.
    InterProiIPR013507. DNA_mismatch_repair_C.
    IPR014762. DNA_mismatch_repair_CS.
    IPR002099. DNA_mismatch_repair_fam.
    IPR011186. DNA_mismatch_repair_MLH1/HexB.
    IPR020667. DNA_mismatch_repair_MutL.
    IPR003594. HATPase_ATP-bd.
    IPR014790. MutL_C.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
    PfamiPF01119. DNA_mis_repair. 1 hit.
    PF08676. MutL_C. 1 hit.
    [Graphical view]
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00853. MutL_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    TIGRFAMsiTIGR00585. mutl. 1 hit.
    PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92FW6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG    50
    KNLIIISDDG IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS 100
    IAAISKMLIT SKKRDADKAF QIKLIGGNEK QVTISVHNEG TKIEIRDLFF 150
    ATPARLKFLR ADKTELTATV DVVKKIALAH PKISFSLTHD GKNLLKLKGQ 200
    NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT SSPTYNRASS 250
    EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPICAIF LQIDPQLVDV 300
    NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDVLELFKN 350
    PLVNKQSPVS KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK 400
    IEQEVENRIE HEQQTRKQYK LGAAKAQLHT TYIISQTEDS IVITDQHAAH 450
    ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL PNEKKADCLY DHREKLYKLG 500
    LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG KNIALTELIE 550
    HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK 600
    LKDIERLFGR 610
    Length:610
    Mass (Da):68,921
    Last modified:December 1, 2001 - v1
    Checksum:iE8ED4C7FFE2316BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03899.1.
    PIRiA97870.
    RefSeqiNP_360998.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL03899; AAL03899; RC1361.
    GeneIDi928512.
    KEGGirco:RC1361.
    PATRICi17890271. VBIRicCon45613_1562.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL03899.1 .
    PIRi A97870.
    RefSeqi NP_360998.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92FW6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC1361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL03899 ; AAL03899 ; RC1361 .
    GeneIDi 928512.
    KEGGi rco:RC1361.
    PATRICi 17890271. VBIRicCon45613_1562.

    Phylogenomic databases

    eggNOGi COG0323.
    HOGENOMi HOG000256550.
    KOi K03572.
    OMAi GTYILAQ.
    OrthoDBi EOG6P8TMH.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.565.10. 1 hit.
    HAMAPi MF_00149. DNA_mis_repair.
    InterProi IPR013507. DNA_mismatch_repair_C.
    IPR014762. DNA_mismatch_repair_CS.
    IPR002099. DNA_mismatch_repair_fam.
    IPR011186. DNA_mismatch_repair_MLH1/HexB.
    IPR020667. DNA_mismatch_repair_MutL.
    IPR003594. HATPase_ATP-bd.
    IPR014790. MutL_C.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10073:SF12. PTHR10073:SF12. 1 hit.
    Pfami PF01119. DNA_mis_repair. 1 hit.
    PF08676. MutL_C. 1 hit.
    [Graphical view ]
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00853. MutL_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    TIGRFAMsi TIGR00585. mutl. 1 hit.
    PROSITEi PS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiMUTL_RICCN
    AccessioniPrimary (citable) accession number: Q92FW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3