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Q92FW6

- MUTL_RICCN

UniProt

Q92FW6 - MUTL_RICCN

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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:RC1361
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. mismatch repair complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610DNA mismatch repair protein MutLPRO_0000177964Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC1361.

Structurei

3D structure databases

ProteinModelPortaliQ92FW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0323.
HOGENOMiHOG000256550.
KOiK03572.
OMAiGTYILAQ.
OrthoDBiEOG6P8TMH.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR011186. DNA_mismatch_repair_MLH1/HexB.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92FW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG
60 70 80 90 100
KNLIIISDDG IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS
110 120 130 140 150
IAAISKMLIT SKKRDADKAF QIKLIGGNEK QVTISVHNEG TKIEIRDLFF
160 170 180 190 200
ATPARLKFLR ADKTELTATV DVVKKIALAH PKISFSLTHD GKNLLKLKGQ
210 220 230 240 250
NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT SSPTYNRASS
260 270 280 290 300
EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPICAIF LQIDPQLVDV
310 320 330 340 350
NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDVLELFKN
360 370 380 390 400
PLVNKQSPVS KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK
410 420 430 440 450
IEQEVENRIE HEQQTRKQYK LGAAKAQLHT TYIISQTEDS IVITDQHAAH
460 470 480 490 500
ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL PNEKKADCLY DHREKLYKLG
510 520 530 540 550
LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG KNIALTELIE
560 570 580 590 600
HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK
610
LKDIERLFGR
Length:610
Mass (Da):68,921
Last modified:December 1, 2001 - v1
Checksum:iE8ED4C7FFE2316BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03899.1.
PIRiA97870.
RefSeqiNP_360998.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03899; AAL03899; RC1361.
GeneIDi928512.
KEGGirco:RC1361.
PATRICi17890271. VBIRicCon45613_1562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03899.1 .
PIRi A97870.
RefSeqi NP_360998.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92FW6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC1361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03899 ; AAL03899 ; RC1361 .
GeneIDi 928512.
KEGGi rco:RC1361.
PATRICi 17890271. VBIRicCon45613_1562.

Phylogenomic databases

eggNOGi COG0323.
HOGENOMi HOG000256550.
KOi K03572.
OMAi GTYILAQ.
OrthoDBi EOG6P8TMH.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPi MF_00149. DNA_mis_repair.
InterProi IPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR011186. DNA_mismatch_repair_MLH1/HexB.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR10073:SF12. PTHR10073:SF12. 1 hit.
Pfami PF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view ]
SMARTi SM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsi TIGR00585. mutl. 1 hit.
PROSITEi PS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiMUTL_RICCN
AccessioniPrimary (citable) accession number: Q92FW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3