Q92FW6 (MUTL_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutL

Gene names

Name:	mutL
Ordered Locus Names:	RC1361

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP-Rule MF_00149
Sequence similarities	Belongs to the DNA mismatch repair MutL/HexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 610	610	DNA mismatch repair protein MutL HAMAP-Rule MF_00149		PRO_0000177964

Sequences

	Sequence		Length	Mass (Da)
	Q92FW6 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E8ED4C7FFE2316BF	FASTA	610	68,921
	10 20 30 40 50 60 MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG KNLIIISDDG 70 80 90 100 110 120 IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS IAAISKMLIT SKKRDADKAF 130 140 150 160 170 180 QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELTATV DVVKKIALAH 190 200 210 220 230 240 PKISFSLTHD GKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT 250 260 270 280 290 300 SSPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPICAIF LQIDPQLVDV 310 320 330 340 350 360 NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDVLELFKN PLVNKQSPVS 370 380 390 400 410 420 KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK IEQEVENRIE HEQQTRKQYK 430 440 450 460 470 480 LGAAKAQLHT TYIISQTEDS IVITDQHAAH ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL 490 500 510 520 530 540 PNEKKADCLY DHREKLYKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG 550 560 570 580 590 600 KNIALTELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK 610 LKDIERLFGR

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03899.1.
PIR	A97870.
RefSeq	NP_360998.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92FW6.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC1361.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03899; AAL03899; RC1361.
GeneID	928512.
KEGG	rco:RC1361.
PATRIC	17890271. VBIRicCon45613_1562.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HOG000256550.
KO	K03572.
OMA	FLFINNR.
ProtClustDB	PRK00095.
Family and domain databases
Gene3D	3.30.230.10. 1 hit. 3.30.565.10. 1 hit.
HAMAP	MF_00149. DNA_mis_repair.
InterPro	IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR003594. HATPase_ATP-bd. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
PANTHER	PTHR10073. PTHR10073. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_RICCN

Accession

Primary (citable) accession number: Q92FW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program