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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-2178-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:RC1361
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779641 – 610DNA mismatch repair protein MutLAdd BLAST610

Structurei

3D structure databases

ProteinModelPortaliQ92FW6
SMRiQ92FW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000256550
KOiK03572
OMAiQHIAHER
OrthoDBiPOG091H015A

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00149 DNA_mis_repair, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR020667 DNA_mismatch_repair_MutL
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF08676 MutL_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit
SUPFAMiSSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q92FW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG
60 70 80 90 100
KNLIIISDDG IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS
110 120 130 140 150
IAAISKMLIT SKKRDADKAF QIKLIGGNEK QVTISVHNEG TKIEIRDLFF
160 170 180 190 200
ATPARLKFLR ADKTELTATV DVVKKIALAH PKISFSLTHD GKNLLKLKGQ
210 220 230 240 250
NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT SSPTYNRASS
260 270 280 290 300
EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPICAIF LQIDPQLVDV
310 320 330 340 350
NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDVLELFKN
360 370 380 390 400
PLVNKQSPVS KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK
410 420 430 440 450
IEQEVENRIE HEQQTRKQYK LGAAKAQLHT TYIISQTEDS IVITDQHAAH
460 470 480 490 500
ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL PNEKKADCLY DHREKLYKLG
510 520 530 540 550
LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG KNIALTELIE
560 570 580 590 600
HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK
610
LKDIERLFGR
Length:610
Mass (Da):68,921
Last modified:December 1, 2001 - v1
Checksum:iE8ED4C7FFE2316BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL03899.1
PIRiA97870
RefSeqiWP_010977912.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL03899; AAL03899; RC1361
GeneIDi928512
KEGGirco:RC1361
PATRICifig|272944.4.peg.1562

Similar proteinsi

Entry informationi

Entry nameiMUTL_RICCN
AccessioniPrimary (citable) accession number: Q92FW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health