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Q92FW6 (MUTL_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutL
Gene names
Name:mutL
Ordered Locus Names:RC1361
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP-Rule MF_00149

Sequence similarities

Belongs to the DNA mismatch repair MutL/HexB family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610DNA mismatch repair protein MutL HAMAP-Rule MF_00149
PRO_0000177964

Sequences

Sequence LengthMass (Da)Tools
Q92FW6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E8ED4C7FFE2316BF

FASTA61068,921
        10         20         30         40         50         60 
MTIKFLSEST INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG KNLIIISDDG 

        70         80         90        100        110        120 
IGMTDKELEI AVERHTTSKF DESDFLNINT FGFRGEALPS IAAISKMLIT SKKRDADKAF 

       130        140        150        160        170        180 
QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELTATV DVVKKIALAH 

       190        200        210        220        230        240 
PKISFSLTHD GKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT 

       250        260        270        280        290        300 
SSPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPICAIF LQIDPQLVDV 

       310        320        330        340        350        360 
NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDVLELFKN PLVNKQSPVS 

       370        380        390        400        410        420 
KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK IEQEVENRIE HEQQTRKQYK 

       430        440        450        460        470        480 
LGAAKAQLHT TYIISQTEDS IVITDQHAAH ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL 

       490        500        510        520        530        540 
PNEKKADCLY DHREKLYKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG 

       550        560        570        580        590        600 
KNIALTELIE HVTETYACHY SIRAGRKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK 

       610 
LKDIERLFGR 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL03899.1.
PIRA97870.
RefSeqNP_360998.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92FW6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC1361.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL03899; AAL03899; RC1361.
GeneID928512.
KEGGrco:RC1361.
PATRIC17890271. VBIRicCon45613_1562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0323.
HOGENOMHOG000256550.
KOK03572.
OMAGTYILAQ.
OrthoDBEOG6P8TMH.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPMF_00149. DNA_mis_repair.
InterProIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR011186. DNA_mismatch_repair_MLH1/HexB.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_ATP-bd.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsTIGR00585. mutl. 1 hit.
PROSITEPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTL_RICCN
AccessionPrimary (citable) accession number: Q92FW6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names