Reviewed, UniProtKB/Swiss-Prot Q92F68 (KPRS1_LISIN)

Names and origin

Protein names

Recommended name:
    Ribose-phosphate pyrophosphokinase 1
      Short name=RPPK 1
    EC=2.7.6.1
Alternative name(s):
    Phosphoribosyl pyrophosphate synthetase 1
      Short name=P-Rib-PP synthetase 1
      Short name=PRPP synthetase 1

Gene names

Name:	prs1
Ordered Locus Names:	lin0238

Organism

Listeria innocua [Complete proteome] [HAMAP]

Taxonomic identifier

1642 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ribose-phosphate pyrophosphokinase 1 HAMAP MF_00583		PRO_0000141152
Regions
	Region	218 – 231	14	Binding of phosphoribosylpyrophosphate Potential
Sites
	Metal binding	134	1	Magnesium Potential
	Metal binding	136	1	Magnesium Potential
	Metal binding	145	1	Magnesium Potential
	Metal binding	149	1	Magnesium Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92F68-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: AB286EB2F80E8ECD	FASTA	318	35,055
	10 20 30 40 50 60 MSNEYFDPKL KIFSLNSNRE LAEEIAKEVG IELGKSSVTH FSDGEIQINI EESIRGCHVY 70 80 90 100 110 120 VIQSTSNPVN QNLMELLIMI DALKRASAAT INIVMPYYGY ARQDRKARSR EPITAKLVAN 130 140 150 160 170 180 LIETAGATRM ITLDMHAPQI QGFFDIPIDH LNAVRLLSDY FSERHLGDDL VVVSPDHGGV 190 200 210 220 230 240 TRARKMADRL KAPIAIIDKR RPRPNVAEVM NIVGNVEGKV CIIIDDIIDT AGTITLAAKA 250 260 270 280 290 300 LREAGATKVY ACCSHPVLSG PAMKRIEDSP IEKLVVTNSI ALPEEKWIDK MEQLSVAALL 310 GEAIVRVHEN ASVSSLFE

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIP 11262 / Serovar 6a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL596164 Genomic DNA. Translation: CAC95471.1.
PIR	AG1462.
RefSeq	NP_469583.1.
3D structure databases
HSSP	HSSP built from PDB template 1DKU based on UniProtKB P14193.
SMR	Q92F68. Positions 2-317.
ModBase	Search...
Genome annotation databases
GeneID	1128646.
GenomeReviews	Gene locus lin0238 in contig AL592022_GR.
KEGG	lin:lin0238.
NMPDR	fig|272626.1.peg.236.
Organism-specific databases
ListiList	LIN00509.
CMR	Search...
Phylogenomic databases
HOGENOM	Q92F68.
OMA	NVAEIMN.
Enzyme and pathway databases
BioCyc	LINN272626:LIN0238-MON.
BRENDA	2.7.6.1. 270396.
Family and domain databases
HAMAP	MF_00583. [Tree]
InterPro	IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. ribP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS1_LISIN

Accession

Primary (citable) accession number: Q92F68

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)