Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q92F40 (ISPD1_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 1
MEP cytidylyltransferase 1
Short name=MCT 1
Gene names
Name:ispD1
Synonyms:ispD
Ordered Locus Names:lin0267
OrganismListeria innocua [Complete proteome] [HAMAP]
Taxonomic identifier1642 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2322322-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1 HAMAP MF_00108
PRO_0000075583

Sites

Site151Transition state stabilizer By similarity
Site221Transition state stabilizer By similarity
Site1531Positions MEP for the nucleophilic attack By similarity
Site2091Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92F40 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 89BD8CB7D117B31D

FASTA23226,040
        10         20         30         40         50         60 
MNYELIFLAA GQGKRMNAEK NKMWLDLVGE PIFIHALRPF LADNRCSKVI VVCQETERKH 

        70         80         90        100        110        120 
VRKLMQQLDV AEDRVEVVKG GSERQYSVAA GLECCGLESV VLVHDGARPF VTLDIIDRLL 

       130        140        150        160        170        180 
LGVKQNKAAI CAVQVKDTVK RVIHDVVKET VDRDNLWQIQ TPQAFELHIL QKAHRLAKKD 

       190        200        210        220        230 
QFLGTDEASL VERIPYPVAI VQGSYYNIKL TTPEDMPLAK AILGELGGKV ND

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL596164 Genomic DNA. Translation: CAC95500.1.
PIRAD1466.
RefSeqNP_469612.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92F40.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1128681.
GenomeReviewsGene locus lin0267 in contig AL592022_GR.
KEGGlin:lin0267.
NMPDRfig|272626.1.peg.265.
PATRIC20297214. VBILisInn102668_0281.

Organism-specific databases

GenoListLIN0267.
CMRSearch...

Phylogenomic databases

HOGENOMHBG672839.
OMASKVIVVC.
ProtClustDBPRK13385.

Enzyme and pathway databases

BioCycLINN272626:LIN0267-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD1_LISIN
AccessionPrimary (citable) accession number: Q92F40
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents