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Q92EQ7 (IOLA_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylmalonate semialdehyde dehydrogenase [acylating]
Short name=MMSA dehydrogenase
Short name=MMSDH
Short name=MSDH
EC=1.2.1.27
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating]
Short name=MSA dehydrogenase
EC=1.2.1.18
Gene names
Name:iolA
Ordered Locus Names:lin0401
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria ›

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP-Rule MF_01670

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP-Rule MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP-Rule MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP-Rule MF_01670

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP-Rule MF_01670
PRO_0000352345

Regions

Nucleotide binding176 – 1805NAD By similarity

Sites

Active site2841Nucleophile By similarity
Binding site3821NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92EQ7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 787B0C3D6EC7026C

FASTA48853,248
        10         20         30         40         50         60 
MADVRKLKNY INGEWVESKA DKYEDVINPA TGEVLCQVPI STRAELDQAA VIAEQAFEKW 

        70         80         90        100        110        120 
SQVAVPRRAR VLFSFQQLLI QHKEELARLI TLENGKNLSE ARGEVQRGIE NVEFAAGAPT 

       130        140        150        160        170        180 
LMMGDSLASI ATDVEAANYR YPVGVVGGIA PFNFPMMVPC WMFPMAIALG NSFILKPSER 

       190        200        210        220        230        240 
TPLLMEKLVE LFSEAGLPKG VFNVVYGAHD VVNGILENET IKAVSFVGSK PVGEYVYKTG 

       250        260        270        280        290        300 
SANLKRVQAL TGAKNHTIVL NDADLEDTVT NVISAAFGSA GERCMACAVV TVEEGIADDF 

       310        320        330        340        350        360 
LAALRTAAQN VKIGNGLDDG VFLGPVIREE NQKRTIAYIE KGVEEGAKLT VDGRETGLSE 

       370        380        390        400        410        420 
GYFVGPTILE DVTTDMTIWK DEIFAPVLSV IRVKNLQEAV RVANQSEFAN GACIFTNNAK 

       430        440        450        460        470        480 
AIRYFREKID AGMLGVNLGV PAPMAFFPFS GWKSSFYGTL HANGKDSVDF YTHKKVVTAR 


YSLKGYEE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL596164 Genomic DNA. Translation: CAC95634.1.
PIRAB1483.
RefSeqNP_469746.1. NC_003212.1.

3D structure databases

HSSPHSSP built from PDB template 1T90 based on UniProtKB P42412.
ProteinModelPortalQ92EQ7.
SMRQ92EQ7. Positions 3-481.
ModBaseSearch...

Protein-protein interaction databases

STRING272626.lin0401.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC95634; CAC95634; CAC95634.
GeneID1128839.
KEGGlin:lin0401.
PATRIC20297488. VBILisInn102668_0418.

Organism-specific databases

GenoListLIN0401.
CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271507.
KOK00140.
OMAVANQSEF.
ProtClustDBCLSK2460970.

Enzyme and pathway databases

UniPathwayUPA00076; UER00148.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_01670. IolA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLA_LISIN
AccessionPrimary (citable) accession number: Q92EQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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