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Q92EF1 (KPRS2_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 2

Short name=RPPK 2
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 2
Short name=P-Rib-PP synthase 2
Short name=PRPP synthase 2
Gene names
Name:prs2
Ordered Locus Names:lin0509
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583_B

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583_B

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Ribose-phosphate pyrophosphokinase 2 HAMAP-Rule MF_00583_B
PRO_0000141153

Regions

Region212 – 22514Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1291Magnesium Potential
Metal binding1311Magnesium Potential
Metal binding1401Magnesium Potential
Metal binding1441Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q92EF1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 2D12EC4A6264766D

FASTA31134,431
        10         20         30         40         50         60 
MTGKMKLFSV TSERPLATKI ADYLDIPLCE VELQKFSDGE VKINIEESIR GTNAYVVQSM 

        70         80         90        100        110        120 
NANVNERLME LLIMVDALKR ASVHSINIIM PYYGYARQDR KARSREPITA KLMANLIQRA 

       130        140        150        160        170        180 
GANRLITVDL HAAQIQGFFN IPIDHLSAVP LIGDYLIEKY GEEDVVVVAP DHSGVVRARR 

       190        200        210        220        230        240 
IADRLNAPIA ILNRKPRPHE DEIMSVIGDV KGKVAIVVDD IIDTGVRATT SADILLEKGA 

       250        260        270        280        290        300 
VEVIACATHS VMAGDATERL QNSRIKEVIT SDSIDLPEEK QFEKLTTISI GRILGRAIEG 

       310 
VQENRSLHPL F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596165 Genomic DNA. Translation: CAC95741.1.
PIRAE1496.
RefSeqNP_469852.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92EF1.
SMRQ92EF1. Positions 4-311.
ModBaseSearch...

Protein-protein interaction databases

STRING272626.lin0509.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC95741; CAC95741; CAC95741.
GeneID1128961.
KEGGlin:lin0509.
PATRIC20297713. VBILisInn102668_0530.

Organism-specific databases

GenoListLIN0509.
CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAQSMNANV.
ProtClustDBCLSK563942.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS2_LISIN
AccessionPrimary (citable) accession number: Q92EF1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families