SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92E84

- HISX_LISIN

UniProt

Q92E84 - HISX_LISIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Histidinol dehydrogenase
Gene
hisD, lin0576
Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Metal bindingi257 – 2571Zinc By similarity
Binding sitei257 – 2571Substrate By similarity
Active sitei322 – 3221Proton acceptor By similarity
Active sitei323 – 3231Proton acceptor By similarity
Binding sitei323 – 3231Substrate By similarity
Metal bindingi356 – 3561Zinc By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei410 – 4101Substrate By similarity
Metal bindingi415 – 4151Zinc By similarity
Binding sitei415 – 4151Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:lin0576
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002513: Chromosome

Organism-specific databases

GenoListiLIN0576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenaseUniRule annotation
PRO_0000135790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272626.lin0576.

Structurei

3D structure databases

ProteinModelPortaliQ92E84.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92E84-1 [UniParc]FASTAAdd to Basket

« Hide

MKTLTGTTEA ILNELRAENS SNSSDQIASE VKAIIENVKN TGDQALFDYT    50
AKFDGVELNE LRIPNSDIQI ATNKVDPAFL EALKEAKANI ESFHNKQKQS 100
AFLDSEKDGV IRGQIIRPLE TVGVYVPGGT AAYPSSVLMN VLPAKIAGVK 150
RIVMITPPSE NGINPHVLAA ANLAGVDEIY QVGGAHGIAA LAYGTASIPK 200
VDKIVGPGNV YVATAKREVF GLVDIDMIAG PSEIVVLADE TAKPAFIAAD 250
LLSQAEHDTL ARAILITTSE KIAQQTKIEL NKQLENLPRK AIAKEATESH 300
GKIIITKSTA EMFHIMNEIA PEHLEVQLEN PMNYLYQIKN AGSIFLGNYA 350
SEPLGDYFAG PNHVLPTSGT AKFFSPLGVE DFTKRSAFIS YTKEALAKEK 400
DAIVLLASKE GLDAHAKAIQ IRFEEEN 427
Length:427
Mass (Da):46,050
Last modified:December 1, 2001 - v1
Checksum:iED6866D8AB2BD74C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596165 Genomic DNA. Translation: CAC95808.1.
PIRiAH1504.
RefSeqiNP_469919.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC95808; CAC95808; CAC95808.
GeneIDi1129037.
KEGGilin:lin0576.
PATRICi20297847. VBILisInn102668_0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596165 Genomic DNA. Translation: CAC95808.1 .
PIRi AH1504.
RefSeqi NP_469919.1. NC_003212.1.

3D structure databases

ProteinModelPortali Q92E84.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272626.lin0576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC95808 ; CAC95808 ; CAC95808 .
GeneIDi 1129037.
KEGGi lin:lin0576.
PATRICi 20297847. VBILisInn102668_0597.

Organism-specific databases

GenoListi LIN0576.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiHISX_LISIN
AccessioniPrimary (citable) accession number: Q92E84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi