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Q92DS8

- GLMS_LISIN

UniProt

Q92DS8 - GLMS_LISIN

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei596 – 5961For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:lin0734
    OrganismiListeria innocua serovar 6a (strain CLIP 11262)
    Taxonomic identifieri272626 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002513: Chromosome

    Organism-specific databases

    GenoListiLIN0734.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135351Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272626.lin0734.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92DS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 216215Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini282 – 421140SIS 1UniRule annotationAdd
    BLAST
    Domaini453 – 591139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92DS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGYIGT NNAKGILLEG LEKLEYRGYD SAGIALQNKD LVTVVKEKGR    50
    IADLASLVPS DAFGTTGIGH TRWATHGKPN HENAHPHQSK SGRFTIVHNG 100
    VIENYTLLKE EYLKNHSFIS DTDTEVIVQL IELFAEKLST KEAFKKALSL 150
    LHGSYAICLI DQTDTETLYA AKNKSPLLIG KGENFNVIAS DAMAVLKETD 200
    EFVEIMDKEI VIVTKDGFTL ETLEGEEVSR ASYTAELDAS DIEKGTYPHY 250
    MLKEIDEQPA VTRKIIQAYQ NEAGEINVDQ TILDEILSSD RIHIVACGTS 300
    YHAGLVGKNL IEKMAKIPVE VHVSSEFGYN LPLMSKKPLF IFITQSGETA 350
    DSRQCLVKVK ELGYRTLTLT NVPGSTLDRE ADHSMYLYAG PEIAVASTKA 400
    YTAQISVLAV LAVSLGREIG DAEALSINLA AELGIVATAM EAMVSSKEVI 450
    EHIAGEYLAT SRNAFFLGRN IDYFVAMEAA LKLKEISYIQ AEGFASGELK 500
    HGTIALIEDG TPVLALITQE SINWNIRGNV NEVLARGAKT CVFAMENVAQ 550
    PGDRFVIPQV HPLLTPLASV IPCQLLAYYA ALHRDCDVDK PRNLAKSVTV 600
    E 601
    Length:601
    Mass (Da):65,656
    Last modified:January 23, 2007 - v3
    Checksum:i3CE15C921930E22E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596166 Genomic DNA. Translation: CAC95966.1.
    PIRiAF1524.
    RefSeqiNP_470077.1. NC_003212.1.
    WP_010990576.1. NC_003212.1.

    Genome annotation databases

    EnsemblBacteriaiCAC95966; CAC95966; CAC95966.
    GeneIDi1129218.
    KEGGilin:lin0734.
    PATRICi20298171. VBILisInn102668_0758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596166 Genomic DNA. Translation: CAC95966.1 .
    PIRi AF1524.
    RefSeqi NP_470077.1. NC_003212.1.
    WP_010990576.1. NC_003212.1.

    3D structure databases

    ProteinModelPortali Q92DS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272626.lin0734.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC95966 ; CAC95966 ; CAC95966 .
    GeneIDi 1129218.
    KEGGi lin:lin0734.
    PATRICi 20298171. VBILisInn102668_0758.

    Organism-specific databases

    GenoListi LIN0734.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP 11262.

    Entry informationi

    Entry nameiGLMS_LISIN
    AccessioniPrimary (citable) accession number: Q92DS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3