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Q92DC9 (ALR_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:lin0885
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Alanine racemase HAMAP-Rule MF_01201
PRO_0000114532

Sites

Active site401Proton acceptor; specific for D-alanine By similarity
Active site2631Proton acceptor; specific for L-alanine By similarity
Binding site1341Substrate By similarity
Binding site3101Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92DC9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6B59D3E24D30D709

FASTA36840,949
        10         20         30         40         50         60 
MVTGWHRPTW IEIDRAAIRE NIKNEQNKLP DKVALWAVVK ANAYGHGIIE TAKIAKEAGA 

        70         80         90        100        110        120 
KGFCVAILDE ALALREAGFR NEFILVLGAT RKEDANLAAK NNISVTVFRE DWLDDLTLEA 

       130        140        150        160        170        180 
PLRIHLKVDS GMGRLGIRSR EEAQRIETTI AIDHQMILEG IYTHFATADQ LETSYFEQQL 

       190        200        210        220        230        240 
AKFQAILSSL TTRPTFVHTA NSAASLLQPQ IDFDAIRFGI SMYGLTPSTE IKNSLPFELK 

       250        260        270        280        290        300 
PALALYTEMV HVKELAPGDS VSYGATYTAT EKEWVATLPI GYADGLIRHY SGFHVLVEGE 

       310        320        330        340        350        360 
RAPIIGRICM DQTIIKLPRE FQTGTKVTII GSDHGNKVTA DDAAEYLGTI NYEVTCLLTE 


RIPRKYIN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596166 Genomic DNA. Translation: CAC96117.1.
PIRAE1543.
RefSeqNP_470226.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92DC9.
SMRQ92DC9. Positions 4-368.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin0885.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC96117; CAC96117; CAC96117.
GeneID1129388.
KEGGlin:lin0885.
PATRIC20298476. VBILisInn102668_0910.

Organism-specific databases

GenoListLIN0885.
CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMAPSECAGV.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_LISIN
AccessionPrimary (citable) accession number: Q92DC9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways