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Q92CV0 (ISPD2_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2
MEP cytidylyltransferase 2
Short name=MCT 2
Gene names
Name:ispD2
Ordered Locus Names:lin1071
OrganismListeria innocua [Complete proteome] [HAMAP]
Taxonomic identifier1642 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 HAMAP MF_00108
PRO_0000075584

Sites

Site141Transition state stabilizer By similarity
Site221Transition state stabilizer By similarity
Site1591Positions MEP for the nucleophilic attack By similarity
Site2161Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92CV0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: DE41EB43F718A630

FASTA23726,848
        10         20         30         40         50         60 
MIYAQILAGG KGTRMGNVSM PKQFLPLNGK PIIVHTVEKF ILNTRFDKIL ISSPKEWMNH 

        70         80         90        100        110        120 
AEDNIKKYIS DDRIVVIEGG EDRNETIMNG IRYVEKTFGL NDEDIIVTHD AVRPFLTHRI 

       130        140        150        160        170        180 
IEENIDAAIE TGAVDTVIEA LDTIVESSNH EFITDIPVRD QMYQGQTPQS FNMKKVYNHY 

       190        200        210        220        230 
QNLSAEKKQI LTDACKICLL AGDQVKLVKG EIFNIKITTP YDLKVANAII QERIAND

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL596167 Genomic DNA. Translation: CAC96302.1.
PIRAF1566.
RefSeqNP_470408.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ92CV0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1129599.
GenomeReviewsGene locus lin1071 in contig AL592022_GR.
KEGGlin:lin1071.
NMPDRfig|272626.1.peg.1061.
PATRIC20298861. VBILisInn102668_1098.

Organism-specific databases

GenoListLIN1071.
CMRSearch...

Phylogenomic databases

HOGENOMHBG672839.
OMAREQQDFW.
ProtClustDBPRK00155.

Enzyme and pathway databases

BioCycLINN272626:LIN1071-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD2_LISIN
AccessionPrimary (citable) accession number: Q92CV0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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